刘志杰    正教授
所在学院生命科学与技术学院
iHuman研究所
研究方向结构生物学
联系方式liuzhj@@shanghaitech.edu.cn
备注百人


个人简介
1984年获得天津师范大学物理系学士学位;1994年获得中国科学院生物物理研究所生物物理学博士学位;1995-1995年在美国匹兹堡大学做博士后;1995-1997年在美国佐治亚大学做博士后;1997-2002年任美国佐治亚大学助理研究员;2002-2006年任美国佐治亚大学副研究员;2006-2013年任中国科学院生物物理研究所 “百人计划”研究员;2013年5月加入上海科技大学iHuman研究所。

主要研究内容
主要从事与人源细胞信号传导相关蛋白,如G蛋白偶联受体(GPCR),的结构生物学和基于结构的药物设计研究。研究工作集中在以下几个方面: 1、人源细胞信号传导相关蛋白的结构生物学研究; 2、基于GPCR三维结构的药物筛选与优化。

代表性论文

1)X. Li, T. Hua, K. Vemuri, S. J. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, GW. Han, M. Iyer, R. Cinar, N. Coffey, J. Wang, M., Wu, V. Katritch, S. Zhao, G. Kunos, L. Bohn, A. Makriyannis, R Stevens. Liu ZJ* (2018) Crystal Structure of the Human Cannabinoid Receptor CB2. Cell, in press. 

2)Y. Peng, J, McCorvy, K, Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, T Che, L Nikolajsen, X Huang, Y Wu, L Shen, W E. Yoshimoto, K Ding, D Wacker, G Han, J Cheng, V Katritch, A A. Jensen, M. Hanson, S Zhao, D E. Gloriam, B L. Roth*, R C. Stevens*, Liu ZJ*, (2018) The Studies of 5-HT2C Receptor Reveal the Structural Basis of GPCR Polypharmacology.Cell, 172(4):719-730. 

3)T. Hua, K. Vemuri, S. Nikas, R. Laprairie, Y. Wu, L. Qu, M. Pu, A. Korde, S. Jiang, J.H. Ho, GW. Han, D. Ding, X. Li, H. Liu, S. M. Hanson, S. Zhao*, L. Bohn*, A. Makriyannis*, R Stevens. Liu ZJ* (2017) Crystal Structure of agonist-bound Human Cannabinoid Receptor CB1. Nature, 547 (7664): 468-471 

4)Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu ZJ*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 546(7657):312-315.

5)T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn*, A. Makriyannis*, R. Stevens*, Liu ZJ* (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762.

6)Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6: 7300.

7)J. Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang*, Liu ZJ*, W. Han*, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented EF-Hand-Like Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109.

8)Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu ZJ*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58

9)Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu ZJ*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9.

10)Ru, H., Ni, X. , Zhao, L. , Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu ZJ*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Res, 23(6):855-8. 

11)OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu ZJ*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086.

12)Wu, D., Li, Y., Song, GJ, Zhang, R., Joachimiak, A., Shaw, N., & Liu ZJ*. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, 69(18), 7294-301. (Cover)

13)Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., Liu ZJ*., Wang, B. C. & Rao, Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, 14(8), 779-84.

14)Shaw, N., Cheng, C., and Liu ZJ*, (2007) Procedure for reductive methylation of protein to improve crystallizability. Nature Protocols DOI: 10.1038/nprot.2007.287


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