范高峰    助理教授、研究员
所在学院生命科学与技术学院
研究方向卵巢癌转移机制和靶向治疗/络氨酸激酶和磷酸酶/多聚adp-核糖化调控
联系方式fangf@@shanghaitech.edu.cn


个人简介
1999年9月-2003年7月,南京大学基础学科教学强化部获学士学位
2003年9月-2009年7月,美国新泽西州罗格斯大学获博士学位
2009年9月-2017年2月,美国冷泉港国家实验室从事博士后研究
2017年2月,加入上海科技大学生命科学与技术学院任助理教授、研究员

主要研究内容
        卵巢癌是一种高发性的妇科癌症,每72名女性当中就有一位会得这种疾病。卵巢癌的致死率在妇科肿瘤疾病中占据首要位置,在整个女性肿瘤致死率中排名第五。由于其发病隐蔽不易察觉,确诊过程往往非常滞后,直接导致5年存活率极低。所以如何提高/改善卵巢癌的早期诊断和有效治疗成为整个卵巢癌研究的重中之重。
        尽管在过去的四十年中,外科手术和放/化疗这些目前最常规的卵巢癌治疗手段有了长足的发展,可是患者的总生存期并没有显著改善。究其根本,还是由于患者错过早期诊断治疗的最佳时机,导致癌症扩散和转移。非常严峻的现实就是目前学术界对于卵巢癌扩散的分子学机制还是非常不清楚。所以,在进一步加快寻找卵巢癌早期诊断指标的同时,理解整个卵巢癌扩散的分子机制,并以此来指导治疗,将会为争取更好的预后效果带来巨大希望。
        另一个严重制约卵巢癌患者预后效果的重要原因是对化疗药物耐药性的产生。基于顺铂和紫杉醇为主的化学治疗是卵巢癌患者手术后的常规治疗。随着我们对于这种异质性极高肿瘤病理特征的进一步认识和了解,分子靶向治疗的早期工作也已经陆续开始,其中包括针对由HGF、VEGF、EGF或者PDGF诱导的信号通路的抑制,以及在BRCA基因功能缺失的患者中试用PARP1抑制剂。在收获越来越多极其令人鼓舞的报导的同时,分子靶向药物的耐药性也仍然是一个亟需解决的重要问题。
        基于此,我的实验室的主要致力于研究和解析卵巢癌扩散转移以及耐药性的分子机制。在充分了解机理的基础上,探索和开发抑制卵巢癌扩散转移以及耐药性的新型药物,提高预后效果。

代表性论文

1.    Gaofeng Fan. FER mediated HGF-independent regulation of HGFR/MET activates RAC1-PAK1 pathway to potentiate metastasis in ovarian cancer. Small GTPase (2017) Nov 3:1-5

2.     Siwei Zhang, Gaofeng Fan, Yuan Hao, Molly Hammell, John Erby Wilkinson, Nicholas K Tonks. Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase. Genes & Development (2017) 31(19):1939-1957 – Selected as “Cover story

3.   Wanjing Shang*, Fei Wang*, Gaofeng Fan#, Haopeng Wang#. Key elements for designing and performing a CRISPR/Cas9-based genetic screen. Journal of Genetics and Genomics (2017) 44(9):439-449. (# co-corresponding author )

4.    Prajwal Gurung*, Gaofeng Fan*, John R. Lukens, Peter Vogel, Nicholas K. Tonks and Thirumala-Devi Kanneganti. Tyrosine Kinase SYK licenses MyD88 Adaptor Protein to Instigate IL-1a-Mediated Inflammatory Disease. Immunity (2017) 46(4), 635-648 (*co-first author)


5.    Gaofeng Fan, Siwei Zhang, Yan Gao, Peter A. Greer and and Nicholas K. Tonks. HGF-independent Regulation of MET and GAB1 by Non-Receptor Tyrosine Kinase FER Potentiates Metastasis in Ovarian Cancer. Genes & Development(2016)30 (13), 1542-1557


6.     Gaofeng Fan*, Saadat Aleem*, Ming Yang, W. Todd Miller and Nicholas K. Tonks. Protein Tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and BRK. Journal of Biological Chemistry(2015) 288 (34), 24923-24934 - Selected as “Paper of the week


7.     Gaofeng Fan*, Kazimierz O. Wrzeszczynski*, Cexiong Fu, Gang Su, Scott R. Powers, Darryl J. Pappin, Robert Lucito and Nicholas K. Tonks. A quantitative proteomics-based signature of platinum sensitivity in ovarian cancer cell lines. Biochemical Journal(2015) 465(3):433-42


8.     Gaofeng Fan, Guang Lin, Robert Lucito and Nicholas K. Tonks. Protein-tyrosine Phosphatase 1B ­Antagonized Signaling by Insulin-like Growth Factor-1 Receptor and kinase BRK/PTK6 in Ovarian Cancer Cells. Journal of Biological Chemistry(2013) 288(34): 24923-34 - Selected as “Paper of the week


9.     Gaofeng Fan*, Matthew J. Simmons*, Sheng Ge, Jui Dutta-Simmons, Jérôme F. Kucharczak, Yacov Ron, David Weissmann, Chiann-Chyi Chen, Chandreyee Mukherjee, Eileen White and Céline Gélinas. Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma. Blood (2010) 115(17):3559-69 - Recommended by “Faculty of 1000”


10.   Gaofeng Fan, Yongjun Fan, Nupur Gupta, Isao Matsuura, Fang Liu, Xiao zhen Zhou, Kun Ping Luand Céline Gélinas. The Peptidyl-Prolyl Isomerase PIN1 markedly enhances the oncogenic activity of the Rel protein subunits of NF-kB. Cancer Research(2009) 69(11): 4589-97


11.   Jui Dutta, Gaofeng Fan and Céline Gélinas. CAPERa is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kB oncoprotein v-Rel. Journal of Virology(2008) 82(21): 10792-802


12.    Nupur Gupta, Jeffrey Delrow, Amar Drawid, Anirvan M. Sengupta, Gaofeng Fan and Céline Gélinas. Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins. Cancer Research(2008) 68(3): 808-14


13.   Younjun Fan*, Jui Dutta*, Nupur Gupta*, Gaofeng Fan* and Céline Gélinas. Regulation of programmed cell death by NF-kB and its role in tumorigenesis and therapy. ReviewAdv Exp Med Biol(2008) 615:223-50(*co-first author)


14.    Matthew J. Simmons, Gaofen Fan, Weixin Zong, Kurt Degenhardt, Eileen White and Céline Gélinas. Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene(2008) 27(10): 1421-8


15.   Jui Dutta*, Yongjun Fan*, Nupur Gupta*, Gaofeng Fan* and Céline Gélinas. Current insights into the regulation of programmed cell death by NF-kB. Review. Oncogene (2006) 25(51): 6800-16 (*co-first author)


16.  Xinjian Liu, Yinxi Huang, Wenjun Zhang, Gaofeng Fan, Chunhai Fan and Genxi Li. Electrochemical investigation of redox thermodynamics of immobilized myoglobin: ionic and ligation effects. Langmuir(2005) 21(1): 375-8


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