刘雪松    助理教授、研究员
所在学院生命科学与技术学院
研究方向癌症生物学
联系方式liuxs@@shanghaitech.edu.cn


个人简介
2002年本科毕业于武汉大学生命科学学院。2007年在中科院上海生命科学研究院健康科学研究所获博士学位。2008年至2015年在美国哈佛大学医学院以及公共卫生学院从事博士后研究工作。2015年6月加入上海科技大学生命科学与技术学院任助理教授、研究员。

主要研究内容
实验室主要研究方向是肿瘤分子遗传和免疫基因组学。研究内容包括:1,肿瘤分子遗传,结合小鼠模型,生化细胞手段研究肿瘤新靶标和机制。研究新肿瘤特异基因、新肿瘤DNA变异的功能;制备新式肿瘤小鼠模型,精确模拟由体细胞多基因突变引发的人类肿瘤。2,肿瘤免疫基因组,从肿瘤基因组角度研究免疫治疗的标志物和靶标。发现新的肿瘤基因组标志物以高效区分免疫治疗有反应和不反应病人;提高肿瘤细胞免疫原性,把免疫治疗不反应病人变成有反应病人。研究手段有:肿瘤基因组生物信息学分析、生化细胞技术和小鼠模型。详情可参考实验室主页:http://liuxslab.slst.shanghaitech.edu.cn

代表性论文


1. Wang SX*, Jia MM*, He ZK, Liu XS#. APOBEC3B and APOBEC  mutational signature as potential predictive markers for immunotherapy response  in non-small cell lung cancer. Oncogene. 2018 Apr 26. doi:  10.1038/s41388-018-0245-9 (* first author; # correspondence)

2.  Chen M, Zhang J, Sampieri K, Clohessy JG, Mendez L, Gonzalez-Billalabeitia E, Liu XS, Lee YR, Fung J, Katon JM,  Menon AV, Webster KA, Ng C, Palumbieri MD, Diolombi MS, Breitkopf SB,  Teruya-Feldstein J, Signoretti S, Bronson RT, Asara JM, Castillo-Martin M,  Cordon-Cardo C, Pandolfi PP. An aberrant SREBP-dependent lipogenic program  promotes metastatic prostate cancer. Nat Genet. 2018 Feb;50(2):206-218.

3. Liu XS, Liu Z, Gerarduzzi C,  Choi DE, Ganapathy S, Pandolfi PP, Yuan ZM. Somatic human ZBTB7A zinc finger  mutations promote cancer progression. Oncogene. 2015 Oct 12. doi:  10.1038/onc.2015.371.

4. Liu XS*, Chandramouly G, Rass E,  Guan Y, Wang G, Hobbs RM, Rajendran A, Xie A, Shah JV, Davis AJ, Scully R,  Lunardi A*, Pandolfi PP. LRF maintains genome integrity by regulating the  non-homologous end joining pathway of DNA repair. Nature Communications. 2015  Oct 8; 6:8325. doi: 10.1038/ncomms9325. (* co-first author)

5. Liu XS, Genet MD, Haines JE,  Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE,  Pandolfi PP, Yuan ZM. ZBTB7A suppresses melanoma metastasis by transcriptionally  repressing MCAM. Mol Cancer Res. 2015, 13(8):1206-17.

6.  Liu XS, Little JB, Yuan ZM.  Glycolytic metabolism influences global chromatin structure. Oncotarget. 2015,  6(6):4214-25.

7.  Liu XS, Haines JE, Mehanna EK,  Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor  suppressor through the transcriptional repression of glycolysis. Genes Dev.  2014, 28(17):1917-28. (Highlighted in Nature Reviews Cancer: Isabel Lokody,    Nature Reviews Cancer, 14, 649 (2014)) 

8.  González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs  RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, Asara JM,  Nardella C, Clohessy JG, Cantley LC, Pandolfi PP. Vulnerabilities of  PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. Cancer  Discov. 2014, 4(8):896-904.

9.  Wang G, Lunardi A, Zhang J, Chen Z, Ala U, Webster KA, Tay Y,  Gonzalez-Billalabeitia E, Egia A, Shaffer DR, Carver B, Liu XS, Taulli R, Kuo WP,  Nardella C, Signoretti S, Cordon-Cardo C, Gerald WL, Pandolfi PP. Zbtb7a  suppresses prostate cancer through repression of a Sox9-dependent pathway for  cellular senescence bypass and tumor invasion. Nat Genet. 2013, 45(7):739-46.  

10.  Zhang HX, Liu ZX, Sun YP, Zhu J, Lu SY, Liu XS, Huang QH, Xie YY, Zhu HB,  Dang SY, Chen HF, Zheng GY, Li YX, Kuang Y, Fei J, Chen SJ, Chen Z, Wang ZG.  Rig-I regulates NF-κB activity through binding to Nf-κb1 3'-UTR mRNA. Proc Natl  Acad Sci U S A. 2013, 110(16):6459-64.

11. Liu XS*, Zhao XD*, Wang X*, Yao  YX, Zhang LL, Shu RZ, Ren WH, Huang Y, Huang L, Gu MM, Kuang Y, Wang L, Lu SY,  Chi J, Fen JS, Wang YF, Fei J, Dai W, Wang ZG. Germinal Cell Aplasia in  Kif18aMutant Male Mice Due to Impaired Chromosome Congression and Dysregulated  BubR1 and CENP-E. Genes Cancer. 2010, 1(1):26-39. (* co-first author)  (Highlighted as cover story)

12.  Shu RZ, Zhang F, Liu XS, Li  CL, Wang L, Tai YL, Wu XL, Yang X, Liao XD, Jin Y, Gu MM, Huang L, Pang XF, Wang  ZG. Target deletion of the cytoskeleton-associated protein palladin does not  impair neurite outgrowth in mice. PLoS One. 2009, 4(9):e6916.

13.  Wu XL, Gu MM, Huang L, Liu XS,  Zhang HX, Ding XY, Xu JQ, Cui B, Wang L, Lu SY, Chen XY, Zhang HG, Huang W, Yuan  WT, Yang JM, Gu Q, Fei J, Chen Z, Yuan ZM, Wang ZG. Multiple synostoses syndrome  is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet. 2009,  85(1):53-63.

14.  Wang Y, Zhang HX, Sun YP, Liu ZX, Liu XS, Wang L, Lu SY, Kong H,  Liu QL, Li XH, Lu ZY, Chen SJ, Chen Z, Bao SS, Dai W, Wang ZG. Rig-I-/- mice  develop colitis associated with downregulation of G alpha i2. Cell Res. 2007,  17(10):858-68.

15. Liu XS, Li XH, Wang Y, Shu RZ,  Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY,  Wang ZG. Disruption of palladin leads to defects in definitive erythropoiesis by  interfering with erythroblastic island formation in mouse fetal liver. Blood.  2007, 110(3):870-76.

16.  Liu XS, Luo HJ, Yang H, Wang  L, Kong H, Jin YE, Wang F, Gu MM, Chen Z, Lu ZY, Wang ZG. Palladin regulates  cell and extracellular matrix interaction through maintaining normal actin  cytoskeleton architecture and stabilizing beta1-integrin. J Cell Biochem. 2007,  100(5):1288-300.

17.  Luo H*, Liu X*, Wang F, Huang  Q, Shen S, Wang L, Xu G, Sun X, Kong H, Gu M, Chen S, Chen Z, Wang Z. Disruption  of palladin results in neural tube closure defects in mice. Mol Cell Neurosci.  2005, 29(4):507-15. (* co-first author) 


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