徐菲    助理教授、研究员
所在学院生命科学与技术学院
iHuman研究所
研究方向结构生物学
联系方式xufei@@shanghaitech.edu.cn
备注青年千人
 
 个人简介 
2006年获得中国科技大学生命科学专业学士学位;2011年获得美国Scripps研究所生物学专业博士学位;2011-2012年上海锐意生物技术有限公司董事(锐意公司创始人之一)。2013年9月加入上海科技大学iHuman研究所任Research Associate Professor,PI。2014年8月兼上海科技大学生命科学与技术学院助理教授、研究员。
 主要研究内容 
主要研究内容:1. 探索研究机体发育及癌症发生信号通路中相关的GPCR蛋白;2. 使用膜蛋白晶体学、冷冻电镜、细胞生物学等结合的手段研究蛋白的结构、配体、及信号通路。
 代表性论文 

1. Zhang X, Zhao F, Wu Y, Yang J,Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR,Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H,Xu F. Crystal structure of a multi-domain human smoothenedreceptor in complex with a super stabilizing ligand” Nature Communications, 8:15383, (2017)


2. Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, ShenY, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S,Stevens RC, Hu LA, Zhong W, Zhang M, Xu F. StructuralBasis for Apelin Control of the Human Apelin Receptor” Structure, doi:10.1016/j.str.2017.04.008, (2017)


3. Zhang X, Stevens RC, Xu F. The importance of ligands for Gprotein-coupled receptor stability TrendsBiochem Sci. 40(2):79-87, (2015)


4.Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B,Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis forallosteric regulation of GPCRs by sodium ions” Science, 337(6091): 232-236,(2012)

5. Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J,Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for theStabilization and Crystallization of G Protein-Coupled Receptors” Structure,20(6): 967-976, (2012)

6. Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, StevensR.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5’ -CarboxamideDerivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Designand Fragment-Based Searching” J Med Chem, 55(9): 4297-4308, (2012)

7. Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C,Jacobson K.A. “Evaluation of Molecular Modeling of Agonist Binding in Light ofthe Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor” JMed Chem, 55(1): 538-552, (2012)

8. Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocket”Structure, 19(9): 1204-1207, (2011) Invited Review.

9. Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, StevensR.C. “Structure of an agonist-bound human A2A adenosine receptor” Science, 332:322-327, (2011)

10. Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of anAutomated High Throughput LCP-FRAP Assay to Guide Membrane ProteinCrystallization in Lipid Mesophases” Crystal Growth & Design, 11(4):1193-1201, (2011)

浏览次数:8329

返回原图
/