张辉    助理教授、研究员
所在学院生命科学与技术学院
研究方向心血管发育与疾病
联系方式zhanghui1@@shanghaitech.edu.cn
 
 个人简介 
2004.09-2008.06,就读于华中农业大学动物科技学院,获农学学士学位;
2008.09-2014.03,就读于中国科学院上海生科院营养所,获理学博士学位;
2014.04-2016.03,在中国科学院上海生科院从事博士后研究,师从周斌教授;
2016.04-2016.10,在中国科学院上海生科院营养所、生化细胞所任副研究员;
2016年11月至今,在上海科技大学生命科学与技术学院任助理教授、研究员。
博士和博士后期间主要从事心脏发育和再生方面的研究,利用遗传谱系示踪技术发现了胚胎心内膜细胞具有多能性,可以分化为瓣膜间充质细胞(Zhang et al, J Biol Chem, 2014),冠状血管内皮细胞(Tian et al, Cell Res, 2013; Tian et al, Science, 2014; Zhang et al, Circ Res, 2016),肝脏血管内皮细胞(Zhang et al, Nat Genet, 2016),心脏内脂肪细胞(Zhang et al, Circ Res, 2016),血管壁细胞(Chen et al, 2016, Nat Commun)等。
2014年被评为中国科学院大学优秀毕业生,博士论文被选为2016年度中国科学院大学百篇优秀博士论文; 2015年获“Sanofi-SIBS”优秀在站博士后奖励基金;2016年获上海细胞生物学会优秀青年学者称号;主持项目有上海市扬帆计划、国自然青年基金等。
 主要研究内容 
每年因心血管疾病导致的死亡约占全球总死亡人数的30%(WHO,2010),因此研究心血管发育与疾病对于人类健康具有重要意义。我们实验室主要致力于心脏发育和心肌再生方面的研究。成年哺乳动物(如人,小鼠等)心肌细胞的再生能力非常有限。因此,心脏受损后的大量心肌细胞死亡和纤维化会导致心脏功能受损而无法恢复,最终走向心力衰竭甚至个体死亡。然而,胚胎期和出生一周内的心肌细胞却具有旺盛的增殖能力,心脏损伤后能够得到快速的再生和修复。因此,我们实验室对以下两个问题比较感兴趣:(1)在发育过程中,是什么原因导致心脏再生能力逐渐丢失?(2)如何提高成体心脏的再生和修复能力?
我们将利用多种遗传工具小鼠,并结合多种动物疾病模型(如心肌梗死、心尖切除等),利用遗传谱系示踪、组织特异性基因操作、细胞命运重塑等多种技术手段,研究发育过程中和疾病状态下心脏中多种细胞类型(如心肌祖细胞,内皮细胞,间充质细胞等)的命运变化及分子调控机制,研发心血管疾病预防和治疗的新靶点。
 代表性论文 
第一作者及通讯作者论文:
1.Tian X#, Hu T#, Zhang H#, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell research. 2013;23:1075-1090 (Cover story
2.Tian X#, Hu T#, Zhang H#, He L#, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014;345:90-94(2014年度中国科学十大进展)
3. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014;289:18681-18692
4. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B. Endocardium contributes to cardiac fat. Circulation research. 2016;118:254-265
5. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nature genetics. 2016;48:537-543 
6. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B. Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls. Circulation research. 2016;118:1880-1893 (Cover story)

合作论文:
1.Zhou B, Honor LB, Ma Q, Oh JH, Lin RZ, Melero-Martin JM, von Gise A, Zhou P, Hu T, He L, Wu KH, Zhang H, Zhang Y, Pu WT. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. Journal of molecular and cellular cardiology. 2012;52:43-47
2.Tian X, Hu T, He L, Zhang H, Huang X, Poelmann RE, Liu W, Yang Z, Yan Y, Pu WT, Zhou B. Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart. PloS one. 2013;8:e80857
3.He L, Tian X, Zhang H, Wythe JD, Zhou B. Fabp4-creer lineage tracing reveals two distinctive coronary vascular populations. Journal of cellular and molecular medicine. 2014;18:2152-2156
4.He L, Tian X, Zhang H, Hu T, Huang X, Zhang L, Wang Z, Zhou B. Baf200 is required for heart morphogenesis and coronary artery development. PloS one. 2014;9:e109493
5. Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B. C-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nature medicine. 2015;21:866-868
6.Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B. Genetic targeting of sprouting angiogenesis using apln-creer. Nature communications. 2015;6:6020
7.Liu Q, Zhang H, Tian X, He L, Huang X, Tan Z, Yan Y, Evans SM, Wythe JD, Zhou B. Smooth muscle origin of postnatal 2nd cvp is pre-determined in early embryo. Biochem Biophys Res Commun. 2016;471:430-436
8.Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B. Genetic lineage tracing identifies in situ kit-expressing cardiomyocytes. Cell research. 2016;26:119-130
9.He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovascular research. 2016;109:419-430
10.Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui K, Zhou B. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nature communications. 2016;7:13369
11.Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nature communications. 2016;7:12422
12. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B. Gata4 regulates fgf16 to promote heart repair after injury. Development. 2016;143:936-949
13.Lu J, Zhou Y, Hu T, Zhang H, Shen M, Cheng P, Dai W, Wang F, Chen K, Zhang Y, Wang C, Li J, Zheng Y, Yang J, Zhu R, Wang J, Lu W, Zhang H, Wang J, Xia Y, De Assuncao TM, Jalan-Sakrikar N, Huebert RC, Bin Z, Guo C. Notch signaling coordinates progenitor cell-mediated biliary regeneration following partial hepatectomy. Scientific reports. 2016;6:22754
14.He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest. 2017(in press)

(# first author;*Corresponding author)

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