林安宁    特聘教授
所在学院生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向信号转导与基因调控(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式alin@@sibcb.ac.cn
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 主要研究内容 
细胞信号转导(signal transduction)在诸如增殖、分化、程序性死亡、转化等细胞活动的调控中都扮演了至关重要的角色。信号转导调控的异常(deregulation)会导致很多人类疾病甚至癌症。实验室的工作主要是利用c-Jun N-terminal p rotein kinase (JNK)和IkB kinase(IKK)/NF-kappaB等分子探针来研究决定信号转导网络的可塑性(plasticity)和特异性(specificity)的分子机制,以试图理解信号转导网络调控的异常怎样导致人类疾病和癌症。
 代表性论文 
                                        1. Liu J, Yan J, Jiang S, Wen J, Cheng L, Zhao Y, and Lin A*. Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation. Proceedings of the National Academy of Science USA 109:191-6, 2012.
2. Lin A*. ATIA: A link between inflammation and hypoxia. Molecular Cell 42: 557-558, 2011.
3. Liu J, Zhao Y, Eilers M, and Lin A*. Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation. Proceedings of the National Academy of Science USA 106:18279-18284, 2009.
4. Tang F, Kokontis J, Lin Y, Liao S. Lin A*, and Xiang J*. Androgen via p21 inhibits TNF alpha-induced JNK activation and apoptosis. Journal of Biological Chemistry 284:32353-32358, 2009.
5. Deng H, Yu F, Chen J, Zhao Y, Xiang J, and Lin A*. Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. Journal of Biological Chemistry 283: 20754-20760, 2008.                                    

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