李凌松    特聘教授
所在学院生命科学与技术学院
中科院上海高等研究院
研究方向干细胞多潜能基因与疾病(中科院上海高等研究院研究员)
联系方式lils@@sari.ac.cn
 
 主要研究内容 
干细胞功能基因与疾病的关系以及基于肿瘤干细胞特征的靶向药物研究。
 代表性论文 
                                        1. J. H. Wen, Y. Y. Chen, Q. K. HuR. P. FengC. Y. Zhang, X. Gao, L. Li. Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3). Diabetologia 52: 504-513, 2009.
2. C. Li, Y. Kong, H. Wang, S. Wang, H. Yu, X. Liu, L. Yang, X. Jiang, L. Li, L. Li. Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis. Journal of Hepatology 50:1174-1183, 2009.
3. Q. Hu,* L. Zhang,* J. Wen, S. Wang, M. Li, R. Feng, X. Yang, L Li. The Egfr-Sox2-Egfr feed-back loop positively regulates the self-renewal of neural precursor cells. Stem Cells 28:279-286, 2010.
4. Yang Li, Hongxi Zhao, Feng Lan, Andrew Le, Liu Chen, Changsheng Lin and Lingsong Li. Generation of Human-Induced Pluripotent Stem Cells from Gut Mesentery-Derived Cells by Ectopic Expression of OCT4-SOX2-NANOG. Cellular Reprogramming 12:237-247, 2010.
5. Ting Liu, Yan-Xia Zhao, Na Tang, Ruo-Peng Feng, Xiao-Long Yang, Nicole Lu, Jin-Hua Wen, Lingsong Li. Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing. PLOS ONE. 2012;7(10):e46934.                                    

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