李劲松    特聘教授
所在学院生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向体细胞重编程(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式jsli@@sibcb.ac.cn
备注杰青、百人
 
 主要研究内容 
1. 完善核移植及iPS技术诱导体细胞重编程的方法,提高体细胞重编程的效率;2. 探讨核移植与iPS技术诱导体细胞重编程的机制;3. 建立新的诱导体细胞重编程的方法;4. 开展体细胞重编程的应用研究。
 代表性论文 
                                        1. Jiang J#, Lv W#, Ye X, Wang L, Zhang M, Yang H, Okuka M, Zhou C, Zhang X, Liu L*, Li Jinsong*. Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation. Cell Res. 13th Nov, 2012.
2. Yang H, Shi L, Wang B, Liang D, Zhong C, Liu W, Nie Z, Liu J, Zhao J, Gao X, Li D, Xu G* & Li Jinsong*. Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells. Cell. 2012, 149: 605-617.
3. Gu TP, Guo F, Yang H, Wu HP, Xu GF, Liu W, Xie ZG, Shi L, He X, Jin SG, Iqbal K, Shi YG, Deng Z, Szabo PE, Pfeifer GP, Li Jinsong* & Xu GL*. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 2011, 477: 606-610.
4. Jiang J, Ding G, Lin J, Zhang M, Shi L, Lv W, Yang H, Xiao H, Pei G, Li Y, Wu J* & Li Jinsong*. Different developmental potential of pluripotent stem cells generated by different reprogramming strategies. J Mol Cell Biol 2011, 3: 197-199.
5. Lin J, Shi L, Zhang M, Yang H, Qin Y, Zhang J, Gong D, Zhang X, Li D & Li Jinsong*. Defects in trophoblast cell lineage account for the impaired in vivo development of cloned embryos generated by somatic nuclear transfer. Cell Stem Cell 2011, 8: 371-375.                                    

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