李佳    特聘教授
所在学院生命科学与技术学院
中科院上海药物研究所
研究方向新药筛选(中科院上海药物研究所研究员)
联系方式jli@@simm.ac.cn
备注杰青
 
 主要研究内容 
针对能量代谢调控的关键分子及相关信号网络进行活性调控机制研究;围绕糖尿病、神经退行性疾病、肿瘤等重大疾病,系统化克隆、表达、纯化和基因转染相关分子靶点,建立分子家族筛选平台和疾病靶向组合筛选模型平台;通过高通量筛选发现先导化合物;研究先导化合物和靶标相互作用模式;研究活性化合物作用机制、发现新靶点。
 代表性论文 
                                        1 Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Zhang LN, Wu F, Zhou HY, Fu YY, Li YY, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J*. Diabetes. 2013. 62(4):1297-1307.
2 A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Qiu BY, Turner N, Li YY, Gu M, Huang MW, Wu F, Pang T, Nan FJ, Ye JM, Li JY*, Li J*. Diabetes 2010, 59:256-265.
3 AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by AICAR and glucose deprivation by down-regulating phsopho-retinoblastoma and cyclin D. Zang Y, Yu LF, Nan FJ, Feng LY, Li J*. J Biol Chem 2009,284:6175-6184.
4 Small molecule antagonizes autoinhibition and activates AMP activated protein kinase in cells. Pang T, Zhang ZS, Gu M, Qiu BY, Yu LF, Cao PR, Shao W, Su MB, Li JY, Nan FJ*, Li J*. J Biol Chem 2008, 283:16051-16060.
5. Berberine, and its more biologically available derivative dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMPK and improve insulin action. Turner N, Li JY, Gosby A, To S, Cheng Z, Miyoshi H, Taketo M, Cooney G, Kraegen E, David J, Hu LH*, Li J*. Diabetes. 2008. 57(5):1414-1418.                                    

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