蒋华良    特聘教授
所在学院生命科学与技术学院
中科院上海药物研究所
研究方向药物设计(中科院上海药物研究所研究员)
联系方式hljiang@@simm.ac.cn
备注杰青
 
 主要研究内容 
发展和应用生物学、化学、计算机和信息科学等多种学科交叉的新方法和新技术,深入开展药物设计、药物新靶标的发现、受体结构与功能研究以及相关新药研发。
 代表性论文 
                                        1. Yun Du, Huaiyu Yang, Yechun Xu, Xiaohui Cang, Cheng Luo, Yanyan Mao, Yuanyuan Wang, Guangrong Qin, Xiaomin Luo, and Hualiang Jiang*. Conformational Transition and Energy Landscape of ErbB4 Activated by Neuregulin1β: One Microsecond Molecular Dynamics Simulations. J. Am. Chem. Soc., 134 (2012), 6720–6731.
2. Huaiyu Yang, Ye Yu, Wei-Guang Li, Fang Yu, Hui Cao, Tian-Le Xu*, Hualiang Jiang*. Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biology, 7(2009), e1000151.
3. Honglin Li, Jin Huang, Lili Chen,Xiaofeng Liu,Tong Chen, Jin Zhu, Weiqiang Lu, Xu Shen, Jian Li, Rolf Hilgenfeld* and Hualiang Jiang*, Identification of Novel Falcipain-2 Inhibitors as Potential Antimalarial Agents through Structure-Based Virtual Screening Journal of Medicinal Chemstry, 52 (2009), 4936–4940.
4. Hualiang Jiang*, Jiarui Wu, Lihe Zhang, Wenping Liang, Feixue Gao, Canping Du, Xuelian Feng & Yongjun Chen. Chemical biology in China takes on signal transduction. Nature Chemical Biology, 4 (2008), 511-518.
5. Juwen Shen, Jian Zhang, Xiaomin Luo, Weiliang Zhu, Kunqian Yu, Kaixian Chen, Yixue Li, Hualiang Jiang*. Predicting protein-protein interactions based only on sequences information. Proceedings of the National Academy of Sciences U.S.A. (PNAS), 104 (2007), 4337-4341.                                    

浏览次数:5603

返回原图
/