惠利健    特聘教授
所在学院生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向肝脏疾病的分子病理机制(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式huilab@@sibcb.ac.cn
备注杰青、百人
 
 主要研究内容 
以肝脏细胞为研究对象,利用细胞生物学、遗传学和基因组学手段,着力于细胞命运维持与转分化、癌化等机理研究,以图揭示细胞命运转变的调控机理,从而阐明维持细胞稳定类型和功能的分子机制,并希望能为肝癌和终末期肝病治疗提供新的思路和策略。
 代表性论文 
                                        1) Huang, P., Zhang, L., Gao, Y., He, Z., Yao, D., Wu, Z., Cen, J., Chen, X., Liu, C., Hu, Y., Hui, L.* et al. (2014). Direct reprogramming of human fibroblasts to functional and expandable hepatocytes. Cell stem cell 14, 370-384.
2) Li, D., Cen, J., Chen, X., Conway, E.M., Ji, Y., and Hui, L.* (2013). Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice. Hepatology 58, 2109-2121.
3) Ji, S., Zhang, L., and .Hui, L..* (2013). Cell fate conversion: direct induction of hepatocyte-like cells from fibroblasts. Journal of cellular biochemistry 114, 256-265.
4) Min, L., Ji, Y., Bakiri, L., Qiu, Z., Cen, J., Chen, X., Chen, L., Scheuch, H., Zheng, H., Qin, L., Zatloukal, K., .Hui, L..*, Wagner, E.F.* et al. (2012). Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nature cell biology 14, 1203-1211.
5) Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., and .Hui, L..*(2011). Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 475, 386-389.                                    

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