韩敬东    特聘教授
所在学院生命科学与技术学院
中科院上海生命科学研究院计算生物学研究所
研究方向生物信息学(中科院上海生命科学研究院计算生物学研究所研究员)
联系方式jdhan@@picb.ac.cn
备注杰青、百人
 
 主要研究内容 
1.研究生物网络的结构,动态及其功能。2.利用functional genomics的数据,寻找疾病有关的基因及进一步研究其病理作用。3.探求遗传基因网络中内在的安全稳定机制。
 代表性论文 
                                        1. Zhou, B., Yang, L., Li, S.F., Huang, J.L., Chen, H.Y., Hou, L., Wang, J.B., Green, C.D., Yan, Z., Huang, X., Zhu L., Xiao H.S., Liu Y. *, and Han J.D. * (2012). Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions, Proc Natl Acad Sci US A. 8;109(19):E1201-9.
2. Jin, C., Li, J., Green, C.D., Yu, X. , Tang, X, Han, D., Xian, Bo., Wang, D, Huang, X., Cao, X., Yan. Z., Hou, L., Liu, J., Shukeir, N., Khaitovich, P., Chen, C.D., Zhang, H., Jenuwein, T. and Han, J.-D.J *, Histone Demethylase UTX-1 Regulates C. elegans Lifespan by Targeting Insulin/IGF-1 Signaling Pathway, Cell Metabolism, 2011, 14: 161-172.
3. Fei, T., Xia, K., Li, Z., Zhou, B., Zhu, S., Chen, H., Zhang, J., Chen, Z., Xiao, H., Han, J.-D.J*. and Chen Y.-G*. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Research, 2010, 20(1): 36-44.
4. Li, Z., Zhang, W., Wu, M., Zhu, S., Gao, C., Sun, L., Zhang, R. Qiao, N., Xue, H., amei Hu, Y., Bao, S.*, Zheng, H.*, and Han, J.-D.J*. Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia. Blood, 2009, 114: 4486-4493.
5. Yu H, Zhu S, Zhou B, Han J-DJ*. Inferring causal relationships among histone methylations and gene expression, Genome Research, 2008, 18: 1314 - 1324.                                    

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