耿美玉    特聘教授
所在学院生命科学与技术学院
中科院上海药物研究所
研究方向肿瘤药理学(中科院上海药物研究所研究员)
联系方式mygeng@@simm.ac.cn
备注杰青、百人
 
 主要研究内容 
1.受体酪氨酸激酶c-Met、ALK、FGFR抑制剂及其生物标志物; 2.肿瘤代谢及其抑制剂; 3.肿瘤微环境与肿瘤转移; 4.蛋白激酶后修饰与肿瘤。
 代表性论文 
                                        1. Ai J, Tang Q, Wu Y, Xu Y, Teng F, Zhou R, Gao X, Zhu Q, Yue X, Pan Q, Xu S, Li J, Huang M, Daugherty-Holtrop J, He Y, Xu H, Fan J, Ding J, Geng M*. The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma. J Natl Cancer Inst. 2011; 103(22):1696-712.
2. Zhang J, Xin X, Chen Q, Xie Z, Gui M, Chen Y, Lin L, Feng J, Li Q, Ding J, Geng M*. Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-kappaB via targeting of Mre11. Int J Cancer. 2012; 130(2):467-77.
3. Zhu, C., Chen, Q., Xie, Z., Ai, J., Tong, L., Ding, J*., Geng, M*. The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc. J Mol Med.2011, 89(3):279-289.
4. Du L, Ai J, Li D, Zhu T, Wang, Y., Knauer, M., Bruhn, T, Liu H, Geng M*, Gu Q, Bringmann, G*. Aspergiolides C and D: spirocyclic aromatic polyketides with potent protein kinase c-Met inhibitory effects. Che. Eur J. 2011, 17(4):1319-1326.
5. Wang Y, Ai J, Chen Y, Wang L, Liu G, Geng M*, Zhang A*. Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4 Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoro- methyl)quinoline as a Novel Anticancer Agent. J Med Chem. 2011, 54(7): 2127-2142.                                    

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