高光侠    特聘教授
所在学院生命科学与技术学院
中科院生物物理研究所
研究方向分子病毒学(中科院生物物理研究所研究员)
联系方式gaogx@@moon.ibp.ac.cn
备注杰青、百人
 
 主要研究内容 
1. 鉴定参与调控HIV-1病毒复制的宿主因子并阐明其作用机制;2. 哺乳细胞转录后基因表达调控机理。
 代表性论文 
                                        1. Zhu Y, Wang X, Goff SP, Gao G*. (2012) Translational repression precedes and is required for ZAP-mediated mRNA decay. EMBO J. 31 (21):4236-46.
2. Chen S, Xu Y, Zhang K, Wang X, Sun J, Gao G*, Liu Y*. (2012) Structure of N-terminal domain of ZAP indicates how a zinc-finger protein recognizes complex RNA. Nat Struct Mol Biol. 19 (4): 430-5.
3. Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, Sun J, Wu L, Zheng YT, Gao, G*. (2011) Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci USA 108, 15834-15839.
4. Chen G, Guo X, Lv F, Xu Y, Gao, G*. (2008) p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. Proc Natl Acad Sci USA 105, 4352-4357.                                    

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