丁建平    特聘教授
所在学院生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向结构生物学和分子生物学(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式jpding@@sibcb.ac.cn
备注杰青、百人
 
 主要研究内容 
主要围绕真核基因表达调控中的一些关键科学问题,包括基因转录表观遗传调控的分子机制、蛋白质翻译起始调控的分子机制、蛋白质正确翻译和保真性的分子机制、以及蛋白质功能失调与疾病发生和发展的关系等,针对一系列参与染色质修饰、mTOR信号通路调控和生物代谢的重要蛋白质和蛋白质复合物、以及治疗性抗体药物等,运用结构生物学、分子生物学、生物化学、细胞生物学等方法,开展蛋白质的结构、功能及其分子机制的研究。
 代表性论文 
                                        1. Minyun Zhou, Xianchi Dong, Carsten Baldauf, Hua Chen, Yanfeng Zhou, Timothy A. Springer, Xinping Luo, Chen Zhong, Frauke Grter, and Jianping Ding*. A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13, Blood, 117, 4623-4631 (2011).
2. Shutong Xu, Jian Wu, Bingfa Sun, Chen Zhong, and Jianping Ding*. Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding, Nucleic Acids Res., 39, 4438-4449 (2011).
3. Xianchi Dong, Minyun Zhou, Chen Zhong, Ning Shen, Bei Yang, and Jianping Ding*. Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetases, Nucleic Acids Res., 38, 1401-1412 (2010). (Featured article and cover story) .
4. Xianchi Dong, Bei Yang, Yingjie Li, Chen Zhong, and Jianping Ding*. Molecular basis of the acceleration of the GDP-GTP exchange of human ras homolog enriched in brain by human translationally controlled tumor protein, J. Biol. Chem., 284, 23754-23764 (2009).
5. Sheng Li, Hao Wang, Baozhen Peng, Meilan Zhang, Daipong Zhang, Sheng Hou, Yajun Guo, and Jianping Ding*. Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance, Proc. Natl. Acad. Sci. USA, 106, 4349-4354 (2009).                                    

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