丁健    特聘教授
所在学院生命科学与技术学院
中科院上海药物研究所
研究方向肿瘤药理学(中科院上海药物研究所研究员)
联系方式jding@@simm.ac.cn
备注中国工程院院士
 
 主要研究内容 
分子靶向抗肿瘤药物的研发、机理研究及相关生物标志物探索,主要为激酶及相关信号转导通路;抗肿瘤转移研究;表观遗传修饰研究。
 代表性论文 
1. Ai J, Tang QJ, Wu YL, Xu Y, Feng T, Zhou RY, Chen Y, Gao X, Zhu QF, Yue XH, Pan QN, Xu SY, Li J, Huang M, Daugherty-Holtrop J, He YZ, Xu HE, Fan J*, Ding J*, Geng MY*. The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma. J Natl Cancer Inst. 103:1696-712, 2011.
2. Jiang Y., Miao ZH*., Xu L., Yu B., Gong JX., Tong LJ., Chen Y., Zhou ZL., Liu HC., Wang Y., Guo YW., Ding J*. Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis pathways. J Biol Chem 286:26461-9, 2011.
3. Xie H., Lin LP., Tong LJ., Jiang Y., Zheng MY., Jiang XY., Zhang XW., Ren XW., Qu WC., Yang Y., Wan H., Chen Y., Zuo JP., Jiang HL., Geng MY., Ding J*. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. Plos One 6:e21487, 2011.
4. Zhang J, Xin X, Chen Q, Xie Z, Gui M, Chen Y, Lin L, Feng J, Li Q, Ding J*, Geng M*. Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-κB via targeting of Mre11. Int J Cancer. 130: 467–477, 2012.
5. Zhu CH., Chen Q., Xie ZQ., Ai J., Tong LJ., Ding J*., Geng MY*. The role of histone deacetylase 7 (HDAC 7) in cancer cell proliferation: regulation on c-Myc. J Mol Med 89: 279-89, 2011.                                    

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