鲍岚    特聘教授
所在学院生命科学与技术学院
中科院上海生命科学研究院生物化学与细胞生物学研究所
研究方向神经细胞蛋白质运输机制与功能(中科院上海生命科学研究院生物化学与细胞生物学研究所研究员)
联系方式baolan@@sibcb.ac.cn
备注杰青、百人
 
 主要研究内容 
细胞内的蛋白质合成后要被运输到不同的区域发挥作用,神经元是一种特化的细胞,除了胞体它还具有长的轴突和树突,因此蛋白质在细胞内的长距离运输就更为重要。我们实验室对两部分的研究内容感兴趣,一方面是受体和离子通道运输的调控机制及在感觉传递中的生理病理意义,另一方面是蛋白质运输的轨道微管翻译后修饰的调控及对神经元发育和神经系统疾病的影响。
 代表性论文 

1. Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Reports, 13: 2794-2807.

2. Bao L*. (2015) Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons. Mol. Pain, 11: 61

3. Zhang X, Bao L, Li S. (2015) Opioid receptor trafficking and interaction in nociceptors. Br. J. Pharmacol., 172: 364–374.

4. Chen XQ, Zhu JX, Wang Y, Zhang X and Bao L*. (2014) CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J. Mol. Cell Biol., 6: 140-153.

5. Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y and Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J. Neurosci., 33: 17884-17896.

6. Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling. J. Cell Sci., 126: 542-553.

7. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L*. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.

8. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696.

9. Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564.

10. Zhang X and Bao L. (2012) Interaction and regulatory functions of μ- and δ-opioid receptors in nociceptive afferent neurons. Neurosci. Bull., 28: 121-130. (Review)

11. He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L* and Zhang X*. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.

12. Li Q, Su YY, Wang H, Li L, Wang Q and Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987.

13. Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, Hökfelt TGM, Bao L*, and Zhang X*. (2010) Coexpression of δ- and µ-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A., 107: 13117-13122.

14. Liu C, Li Q, Su YY and Bao L* (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417.

15. Zhang X*, Bao L* and Ma GQ (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathways. Progress in Neurobiology, 90: 276-283. (Review)

16. Ma GQ, Wang B, Wang HB, Wang Q and Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 9: 2165–2179.

17. Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and Bao L* (2008) Voltage-gated sodium channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit. J. Cell Sci. 121: 3243-3252.

浏览次数:7182

返回原图
/