管吉松    副教授、研究员

所在学院

生命科学与技术学院

研究方向

记忆编码与存储的神经机制

联系方式

guanjs@@shanghaitech.edu.cn



个人简介


1997-2001,    南京大学, 生物化学系, 本科
2001-2006,    中科院神经科学研究所,博士
2006-2010,    美国麻省理工学院, 博士后
2011-2017,    清华大学,生命学院,特聘研究员,博导
2017.11-至今,  上科大生命科学与技术学院,副教授、研究员


主要研究内容


实验室关注于研究哺乳动物大脑中的记忆存储、提取的相关编码规律和神经生物学机制。我们独立发展了大规模单神经元解析度的在体成像技术,寻找和追踪小鼠皮层内神经元群体在长期记忆形成于提取过程中的反应活动特征,探索脑对外界多模态环境的编码存储规律;利用多种手段,解析大脑中存储记忆的特异性神经环路以及表观遗传调控对记忆印迹细胞的作用,研究记忆的灵活性与稳定性调节机制;利用脑机接口等工程与医学手段,探索对脑损伤、脑疾病的修复治疗新方法。


代表性论文



Epigenetic regulators in memory and diseases:

 

1.    Shiguo Liu# , Miaomiao Tian# Fan He#,  Jiani Li#, Hong Xie#, Wenmiao Liu, Yeting Zhang,  Ru Zhang, Mingji Yi, Fengyuan Che, Xu Ma, Yi Zheng,  Hao Deng, Guiju Wang,  Lang Chen, Xue Sun, Yinglei Xu, Jingli Wang, Yucui Zang, Mengmeng Han, Xiuhai Wan, Hongzai Guan, Yinlin Ge, Chunmei Wu, Haiyan Wang, Hui Liang, Hui Li, Ni Ran, Zhaochuan Yang, Huanhuan Huang, Yanzhao Wei, Xueping Zheng, Xiangrong Sun, Xueying Feng, Lanlan Zheng, Tao Zhu, Wenhan Luo,Qinan Chen, Yuze Yan, Zuzhou Huang, Zhongcui Jing, Yixia Guo, Xuzhan Zhang, Christian P. Schaaf, Jinchuan Xing, Chuanyue Wang&, Fuli Yu& , Ji-Song Guan2019Mutations in ASH1L confer susceptibility to Tourette Syndrome. Molecular Psychiatry (Epub ahead of print)

 

2.    Xinlu Ding, SanXiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie& Ji-Song Guan#(2017) Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation. Nat Neurosci. May;20(5):690-699, doi:10.1038/nn.4536

 

3.    Zhu T, Liang C, Li D, Tian M, Liu S, Gao G and Guan JS#. (2016) Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1. Sci Rep. 6: 26597.

 

4.    Guan JS#, Xie H, Ding XL. (2015) The role of epigenetic regulation in learning and memory. Exp Neuro.268: 30-36.(Review)

 

5.    Liu P, Zhu T, Liang C, Bai B, Gao GJ and Guan JS#. (2014) A one-step screening system for multi-zinc finger proteins targeting a long-DNA sequence. SCIENTIA SINICA Vitae 44: 1061–1072

 

6.    Guan JS*, Haggarty SJ*, Giacometti E*, Dannenberg JH*, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang XY, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R and Tsai LH. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60.

 

Neuronal circuits of memory and encoding mechanisms

 

7.    Dong Li*, Guangyu Wang*, Hong Xie, Yi Hu, Ji-Song Guan#, Claus C Hilgetag# (2019) Multimodal memory components and their long-term dynamics identified in cortical layers II/III but not layer V. Frontiers in Integrative Neuroscience13:54

 

8.    Guangyu Wang*, Lun Wang*, Hong Xie*, Wenhan Luo, Yixiang Wang, Jun Jiang, Chun Xiao, Feng Xing, Ji-Song Guan#2019Switching from fear to no fear by different neural ensembles in mouse retrosplenial cortex. Cerebral Cortex Mar 19. pii: bhz050. doi: 10.1093/cercor/bhz050

 

9.    Jun Jiang, Guangyu Wang, Wenhan Luo, Hong Xie, Ji-Song Guan#. (2018) Mammillary body regulates state-dependent fear by alternating cortical oscillations. Sci Rep. 6: 26597. Sep 7;8(1):13471. doi: 10.1038/s41598-018-31622-z

 

10.   Ruxing Fu, Wenhan Luo, Roy Nazempour, Daxin Tan, He Ding, Kaiyuan Zhang, Lan Yin,Ji-Song Guan#, Xin Sheng#, (2018) Implantable and Biodegradable Poly (L-lactic acid) Fibers for Optical Neural Interfaces, Advanced Optical Materials, Feb, 3(6):1700941 10.1002/adom.201700941

 

11.   Guan JS#, Jiang J, Xie H and Liu K-Y. (2016) How does the sparse memory Engram: Neurons encode the memory of a spatial-temporal event? Front. Neural Circuits 10: 61. (Review)

 

12.   Xie H, Liu Y, Zhu YZ, Ding XL, Yang YH and Guan JS#. (2014) In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A.111: 2788-2793.




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