罗振革    副院长、正教授
所在学院生命科学与技术学院
研究方向神经发育与再生
联系方式luozhg@@shanghaitech.edu.cn
备注杰青、百人


个人简介
学习经历
1988.7 南开大学生物工程专业 学士
1991.8  军事医学科学院免疫学专业 硕士
1995.7 军事医学科学院免疫学专业 博士

工作经历
1991.9-1992.8 解放军254医院  传染科实验室工作人员
1995.8-1999.12 军事医学科学院 助理研究员、副研究员
2000.1-2003.5 阿拉巴马大学伯明翰分校  博士后
2003.6-2018.8 中国科学院神经科学研究所 研究员、高级研究员、所长助理、副所长
2012-2018 上海科技大学  特聘教授
2014-2018 中国科学院大学 岗位教授
2018.9-至今 上海科技大学生命学院  正教授(Tenured)
2003年入选中科院“百人计划,2008年获得国家自然科学基金委杰出青年基金项目支持,2018年入选国家万人计划科技创新领军人才。

主要研究内容
总目标:阐明脑结构与神经环路形成的分子细胞机制;揭示神经生长与退化相关神经系统疾病机理;开发新的神经损伤修复手段。
主要研究内容:大脑皮层的发育与进化;神经生长与导向;突触形成与修剪;神经损伤与修复。  

代表性论文

1. He, M., Ding, Y.T., Chu, C., Tang, J., Xiao, Q. and Luo,  Z.G.* (2016) Autophagy induction stabilizes microtubules and promotes  axon regeneration after spinal cord injury. Proc. Natl. Acad. Sci.  USA. 113(40):11324-11329.

2. Ju, X.C., Hou, Q.Q., Sheng,  A.L., Wu, K.Y., Zhou, Y., Jin, Y., Wen, T.Q., Yang, Z.G., Wang, X.Q.,  Luo, Z.G.* (2016) The hominoid-specific gene TBC1D3 promotes  generation of basal neural progenitors and induces cortical folding in mice.  eLife. Aug 9;5. pii: e18197. doi:  10.7554/eLife.18197.

3. Wu, K.Y., Zuo, G. L., Li, X.F., Ye, Q., Deng,  Y.Q., Huang, X. Y., Wu-Chun Cao, Qin, C. F., Luo, Z.G.* (2016)  Vertical transmission of Zika virus targeting the radial glial cells affects  cortex development of offspring mice. Cell Res.  26:645-654. (Cover story, Highlighted, and received the 2016 Sanofi-Cell  Research Outstanding Paper Award).

4. Wu, K.Y., He, M., Hou, Q.Q., Sheng,  A.L., Yuan, L., Liu, Y., Liu, W.W., Li, G., Jiang, X.Y., Luo,  Z.G.* (2014) Semaphorin-3A activates the guanosine triphosphatase Rab5  to promote growth cone collapse and callosal axon projection. Sci.  Signal. 7, ra81.

5. Xu, X.H., Deng, C.Y., Liu Y., He, M.,  Peng, J., Wang, T., Yuan, L., Zheng, Z.S., Blackshear, P.J & Luo,  Z.G.* (2014) MARCKS regulates membrane targeting of Rab10 vesicles to  promote axon development. Cell Res. 24:  576–594.

6. Wang, J.Y., Chen, F., Fu, X.Q., Ding, C.S., Zhou, L., Zhang,  X.H. & Luo, Z.G.* (2014) Caspase-3 cleavage of disheveled  induces elimination of postsynaptic structures. Dev. Cell   28:670–684 (Highlighted by Preview in Developmental Cell 28,  604-606).

7. Deng, C.Y., Lei, W.L., Xu, X.H., Ju, X.C., Liu, Y. &  Luo, Z.G.* (2014) Jip1 mediates anterograde transport of Rab10  cargos during neuronal polarization. J. Neurosci.  34:1710-1723.

8. Liu, Y., Xu, X.H., Chen, Q., Wang, T.,  Deng, C.Y., Song, B.L., Du, J.L., Luo, Z.G.* (2013) Myosin Vb  controls biogenesis of post-Golgi Rab10 carriers during axon development.  Nat. Commun. 4:2005 doi:  10.1038/ncomms3005.

9. Lei, W.L., Xing, S.G., Deng, C.Y., Ju, X.C.,  Jiang, X.Y., Luo, Z.G.* (2012) Laminin/beta1 integrin signal  triggers axon formation by promoting microtubule assembly and stabilization.  Cell Res. 22:954-972.

10. Wang, T., Liu, Y.,  Xu, X.H., Deng, C.Y., Wu, K.Y., Zhu, J., Fu, X.Q., He,M., and Luo,  Z.G.* (2011) Lgl1 Activation of Rab10 Promotes Axonal Membrane  Trafficking Underlying Neuronal Polarization. Dev. Cell.  21:431-444. (Cover story and highlighted by “Faculty of 1000  Biology”).

11. Yang, G.Y., Liang, B., Zhu, J., and Luo,  Z.G.*(2011) Calpain activation by wingless-type MMTV integration site  family, member 5A (Wnt5a) promotes axonal growth. J. Biol.  Chem. 286: 6566-6576. (Highlighted by “Faculty of 1000  Biology”).

12. Wang, J., Fu, X.Q., Lei, W.L., Wang, T., Sheng, A.L.,  Luo, Z.G.* (2010) Nuclear Factor Kappa B Controls AChR  Clustering by Regulating Rapsyn Expression at the Neuromuscular Junction.  J. Neurosci. 30: 11104-11113.

13. Liang, B.,  Duan, B.Y., Zhou, X.P., Gong, J.X., Luo, Z.G.* (2010) Calpain  activation promotes bace1 expression, APP processing, and amyloid plaque  formation in a transgenic mouse model of Alzheimer disease. J Biol  Chem. 285: 27737-27744.

14. Zhou, X.P., Wu, K.Y., Liang,  B., Fu, X.Q., Luo, Z.G.*(2008) TrkB-mediated Activation of  Geranylgeranyltransferase I Promotes Dendritic Morphogenesis. Proc.  Natl. Acad. Sci. USA. 105: 17181-17186.

15. Wang, J., Ruan,  N.J., Qian, L., Chen, F., Luo, Z.G.*(2008) Wnt/β-catenin  signaling suppresses rapsyn expression and inhibits AChR clustering at the  neuromuscular junction. J. Biol. Chem. 283:  21668-21675.

16. Zhang, X., Zhu, J., Yang, G.Y., Wang, Q.J., Qian, L.,  Chen, Y.M., Chen, F., Tao, Y., Hu, H.S., Wang, T., and Luo,  Z.G.*(2007) Dishevelled promotes axon differentiation by regulating  atypical protein kinase C. Nat. Cell Biol. 9, 743-754.  (Highlighted by News and Views in the same issue of Nat. Cell Biol., “Faculty of  1000 Biology”, and Nature China).

17. Chen, F., Qian, L., Yang, Z.H.,  Huang, Y., Ngo, S.T., Ruan, N.J., Wang, J., Schneider, C., Noakes, P.G., Ding,  Y.Q., Mei, L., and Luo, Z.G.* (2007) Rapsyn interaction with  Calpain stabilizes AChR clusters at the neuromuscular junction.  Neuron 55: 247-260. (Highlighted by “Faculty of 1000  Biology”).

18. Chen, Y.M., Wang, Q.J., Hu, H.S.,Yu, P.C., Zhu, J.,  Drewes, G., Piwnica-Worms, H., Luo, Z.G.* (2006) Microtubule  affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/aPKC  complex in regulating hippocampal neuronal polarity. Proc. Natl.  Acad. Sci. USA 103: 8534-8539.  


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