洪诗雅    副教授,研究员
所在学院生命科学与技术学院
研究方向巨噬细胞代谢、功能及生物学
联系方式tsyhorng@@shanghaitech.edu.cn


个人简介
1995-1999 美国加州大学伯克利, 分子细胞学,学士学位
1999-2003 耶鲁大学, 免疫学,博士学位
2003-2007 耶鲁大学Ruslan Medzhitov实验室,博士后研究
2007-2008 哈佛大学医学院Anjana Rao实验室,博士后研究
2008-2014 哈佛公卫学院,助理教授
2015-2018 哈佛公卫学院,副教授
2018.10-至今 上海科技大学,生命科学与技术学院,副教授,研究员

主要研究内容
巨噬细胞是极具动力性及调节多种生理功能的细胞。本课题组致力于研究巨噬细胞代谢,包括不同代谢途径与激活巨噬细胞的信号通路之间的相互作用,以及线粒体代谢对染色质的调控作用。课题组的研究目标在阐述细胞代谢调节巨噬细胞功能的主要机理,为多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段。

代表性论文

论文

1.  Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. *co-corresponding authors.  Cell. Jul. 10, 2009.
PMID: 19596240

2.  Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer A, and Horng T.  A critical role for calcium mobilization in activation of the NLRP3 inflammasome. PNAS. Jul. 10, 2012.  PMID: 22733741

3.  Byles V*, Covarrubias AJ*, Ben-Sahra I, Lamming D, Sabatini D, Manning B and Horng T.  The TSC-mTOR pathway regulates macrophage polarization. *co-first authorship.  Nature Communications. Nov. 27, 2013. PMID: 24280772

4.  Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM and Horng T.  Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. PNAS. Oct. 28, 2014.PMID: 25313054

5.  Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Stapornkul TP, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, and Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. eLIFE. Feb. 19, 2016. PMID: 26894960

·         Commentary by Torres A et al. Immunometabolism: Metabolism fine-tunes macrophage activation. eLIFE. Feb 19, 2016. PMID: 26894957


6.  Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki, Suzuki T, Yamamoto M, Horng T, and Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Science Reports. Aug 18;7(1):8801. PMID: 28821730


7.  Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, and Blander JM. Innate sensing of microbial viability orchestrates stress-mediated autophagy of the endoplasmic reticulum. Cell. Nov 2;171(4):809-823. PMID: 29056340


综述

1.    Medzhitov R and Horng T*.  Transcriptional control of the inflammatory response. *co-corresponding authors.   Nature Reviews Immunology. Oct. 2009. PMID: 19859064

2.     Horng T and Hotamisligil.  Linking the inflammasome to obesity-related disease.  Nature Medicine. Feb. 2011. PMID: 21297609 

3    Covarrubias A, Byles V, and Horng T.  ROS sets the stage for macrophage differentiation.  Cell Research. Aug. 2013.PMID: 23835480

4.      Kagan JC and Horng T.  NLRP3 inflammasome activation:  CD36 serves double duty.  Nature Immunology. Aug. 2013. PMID: 23867926

5.     Horng, T.  Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.  Trends in Immunology. Jun. 2014. PMID: 24646829 

6.    Covarrubias AJ and Horng T.  IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, Jun. 2014. PMID: 24896536

7.    Horng, T.  mTOR trains heightened macrophage responses. Trends in Immunology. Jan. 2015. PMID: 25488670

9.  Covarrubias AJ, Aksoylar HI and Horng T.  Control of macrophage metabolism and activation by mTOR and Akt signaling.  Seminars in Immunology. Aug. 2015. 
PMID: 26360589

10.  Langston PK, Shibata M and Horng T.  Metabolism supports macrophage activation.  Frontiers in Immunology. Jan. 2017. PMID: 28197151. 


11.  Olivas J and Horng T.  Sugar fuels T cell memory. Nature Cell Biology. Jan. 2018. PMID:29269950.


12.  Jung J, Zeng H, and Horng T. Metabolism as a guiding force for immunity. Nature Cell Biology. In press.


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