洪诗雅    副教授,研究员
所在学院生命科学与技术学院
研究方向巨噬细胞代谢、功能及生物学
联系方式tsyhorng@@shanghaitech.edu.cn


个人简介
1995-1999 美国加州大学伯克利, 分子细胞学,学士学位
1999-2003 耶鲁大学, 免疫学,博士学位
2003-2007 耶鲁大学Ruslan Medzhitov实验室,博士后研究
2007-2008 哈佛大学医学院Anjana Rao实验室,博士后研究
2008-2014 哈佛公卫学院,助理教授
2015-2018 哈佛公卫学院,副教授
2018.10-至今 上海科技大学,生命科学与技术学院,副教授,研究员

主要研究内容
巨噬细胞是极具动力性及调节多种生理功能的细胞。本课题组致力于研究巨噬细胞代谢,包括不同代谢途径与激活巨噬细胞的信号通路之间的相互作用,以及线粒体代谢对染色质的调控作用。课题组的研究目标在阐述细胞代谢调节巨噬细胞功能的主要机理,为多种生理和病理狀态如先天免疫、炎症等提供前瞻思路及可能的诊疗手段。

代表性论文

     论文

     1.Hargreaves DC, Horng T*, Medzhitov R*.   Control of inducible gene expression by signal-dependent transcriptional   elongation. *co-corresponding authors.  Cell. Jul. 10, 2009.PMID: 19596240

     2.Murakami T, Ockinger J, Yu J, Byles V,   McColl A, Hofer A, and Horng   T.  A critical role for calcium mobilization in   activation of the NLRP3 inflammasome. PNAS. Jul. 10, 2012.  PMID:   22733741

     3.Byles V*, Covarrubias AJ*, Ben-Sahra I,   Lamming D, Sabatini D, Manning B and Horng T.  The TSC-mTOR pathway regulates   macrophage polarization. *co-first authorship.  Nature Communications. Nov.   27, 2013. PMID: 24280772

      4.Yu J, Nagasu H, Murakami T, Hoang H,   Broderick L, Hoffman HM and Horng   T.  Inflammasome activation leads to Caspase-1-dependent   mitochondrial damage and block of mitophagy. PNAS. Oct. 28, 2014.PMID:   25313054

      5.Covarrubias AJ, Aksoylar HI, Yu J,   Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Stapornkul TP,   Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, and Horng T. Akt-mTORC1 signaling   regulates Acly to integrate metabolic input to control of macrophage  activation. eLIFE.   Feb. 19, 2016. PMID: 26894960

     ·Commentary by   Torres A et al. Immunometabolism: Metabolism fine-tunes macrophage activation. eLIFE.   Feb 19, 2016. PMID: 26894957

      6.Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano   S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki, Suzuki T,   Yamamoto M, Horng   T, and Kashihara N. Infiltration of M1, but not M2,   macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient  mice. Science Reports. Aug 18;7(1):8801. PMID: 28821730

      7.Moretti J, Roy S, Bozec D, Martinez J,   Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green   DR, and Blander JM. Innate sensing of microbial viability orchestrates stress-mediated autophagy of the endoplasmic reticulum. Cell. Nov   2;171(4):809-823. PMID: 29056340

      8.P. Kent Langston1, Aya Nambu1, Jonathan Jung1,2, Munehiko Shibata1, H.   Ibrahim Aksoylar1, Jiahui Lei1, Peining Xu3, Mary T. Doan3, Helen Jiang3,   Michael R. MacArthur1, Xia Gao4, Yong Kong5, Edward T. Chouchani6, Jason W.   Locasale4, Nathaniel W. Synder3, and Tiffany Horng1,7* Glycerol phosphate   shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature  Immunology. In press.

     综述

     1.Medzhitov R   and Horng T*.    Transcriptional control of the inflammatory response.

 *co-corresponding   authors.   Nature   Reviews Immunology. Oct. 2009. PMID: 19859064

2.Horng T and   Hotamisligil.  Linking the inflammasome to obesity-related  disease.  Nature Medicine. Feb. 2011. PMID: 21297609

3.Covarrubias A,   Byles V, and Horng   T.  ROS sets the stage for macrophage differentiation.  Cell Research. Aug. 2013.PMID: 23835480

4.Kagan JC   and Horng T.    NLRP3 inflammasome activation:  CD36 serves double duty.  Nature Immunology . Aug.   2013. PMID: 23867926

5.Horng, T.  Calcium signaling   and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.  Trends   in Immunology. Jun. 2014. PMID: 24646829

6.Covarrubias AJ   and Horng T.    IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, Jun.   2014. PMID: 24896536

7.Horng, T.  mTOR   trains heightened macrophage responses. Trends in Immunology. Jan. 2015. PMID:   25488670

8.Covarrubias AJ, Aksoylar HI and Horng T.  Control of   macrophage metabolism and activation by mTOR and Akt signaling.  Seminars in Immunology. Aug.   2015. 

9.Langston PK, Shibata M and Horng T.  Metabolism   supports macrophage activation.  Frontiers in Immunology. Jan. 2017. PMID:   28197151

10.Olivas J   and Horng T.    Sugar fuels T cell memory. Nature   Cell Biology. Jan. 2018. PMID29269950.

11.Jung J, Zeng H,   and Horng T.   Metabolism as a guiding force for immunity. Nature Cell Biology. In   press.

12.Yan J, Wang R and Horng T. mTOR is Key to T   cell Transdifferentiation. Cell Metabolism. Feb. 2019. PMID: 30726756.

  



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