Achievement in the year of 2017


1.Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice.

Hu, R., Zhang, J., Luo, M., and Hu, J*. (2017). Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice. Cereb Cortex 27, 3110-3124.


2.The emerging roles of the DDX41 protein in immunity and diseases.

Jiang, Y., Zhu, Y.P., Liu, Z.J*., and Ouyang, S.Y. (2017). The emerging roles of the DDX41 protein in immunity and diseases. Protein Cell 8, 83-89.


3.Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities.

Yang, L.Y., Liu, X.F., Yang, Y., Yang, L.L., Liu, K.W., Tang, Y.B., Zhang, M., Tan, M.J., Cheng, S.M., Xu, Y.C., Yang, H.Y., Liu, Z.J., Song, G.J., and Huang, W. (2017). Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities. Acta Pharmacol Sin 38, 56-68.


4.Single-Molecule Optical-Trapping Techniques to Study Molecular Mechanisms of a Replisome.

Sun, B., and Wang, M.D. (2017). Single-Molecule Optical-Trapping Techniques to Study Molecular Mechanisms of a Replisome. Methods Enzymol 582, 55-84.


5.A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.

Koledova, Z., and Lu, P*. (2017). A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland. Methods Mol Biol 1501, 217-231.


6.Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis.

Li, Z., Li, Y., Chen, W., Cao, Q., Guo, Y., Wan, N., Jiang, X., Tang, Y.J., Wang, Q., and Shui, W*. (2017). Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis. Anal Chem 89, 877-885.


7.Optimization of Acquisition and Data-Processing Parameters for Improved Proteomic Quantification by Sequential Window Acquisition of All Theoretical Fragment Ion Mass Spectrometry.

Li, S., Cao, Q., Xiao, W., Guo, Y., Yang, Y., Duan, X., and Shui, W*. (2017). Optimization of Acquisition and Data-Processing Parameters for Improved Proteomic Quantification by Sequential Window Acquisition of All Theoretical Fragment Ion Mass Spectrometry. J Proteome Res 16, 738-747.


8.CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer.

Su, S., Zou, Z., Chen, F., Ding, N., Du, J., Shao, J., Li, L., Fu, Y., Hu, B., Yang, Y., Sha, H., Meng, F., Wei, J., Huang, X*., and Liu, B*. (2017). CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology 6, e1249558.


9.Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space.

Zhou, Q., Sun, X., Xia, X., Fan, Z., Luo, Z., Zhao, S., Shakhnovich, E*., and Liang, H*. (2017). Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space. J Phys Chem Lett 8, 407-414.


10.Structural variation in amyloid-beta fibrils from Alzheimer's disease clinical subtypes.

Qiang, W., Yau, W.M., Lu, J.X., Collinge, J., and Tycko, R. (2017). Structural variation in amyloid-beta fibrils from Alzheimer's disease clinical subtypes. Nature 541, 217-221.


11.GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary.

Jiang, C., Diao, F., Sang, Y.J., Xu, N., Zhu, R.L., Wang, X.X., Chen, Z., Tao, W.W., Yao, B., Sun, H.X., Huang, X. , Xue, B., and Li, C.J. (2017). GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet 13, e1006535.


12.A hypothalamic circuit that controls body temperature.

Zhao, Z.D., Yang, W.Z., Gao, C., Fu, X., Zhang, W., Zhou, Q., Chen, W., Ni, X., Lin, J.K., Yang, J., Xu, X.H., and Shen, W.L *. (2017). A hypothalamic circuit that controls body temperature. Proc Natl Acad Sci USA 114, 2042-2047.


13.Corrigendum: CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.

Su, S#., Hu, B#., Shao, J., Shen, B., Du, J., Du, Y., Zhou, J., Yu, L., Zhang, L., Chen, F., Sha, H., Cheng, L., Meng, F., Zou, Z., Huang, X*., and Liu, B*. (2017). Corrigendum: CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep 7, 40272.


14.Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein.

Yan, B., Liu, L., Huang, S., Ren, Y., Wang, H., Yao, Z., Li, L., Chen, S., Wang, X., and Zhang, Z. (2017). Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chem Commun 53, 3637-3640.


15.Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae.

Wang, X., Li, S., Wang, H., Shui, W*., and Hu, J. (2017). Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae. eLife 6. e23816.


16.A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse.

Chen, J#., Du, Y#., He, X., Huang, X*., and Shi, Y.S*. (2017). A Convenient Cas9-based Conditional Knockout Strategy for Simultaneously Targeting Multiple Genes in Mouse. Sci Rep 7, 517.


17.Stochastic Optical Reconstruction Microscopy Imaging Technique and Application.

Yang, J., Tian, C., and Zhong, G*., (2017). Stochastic Optical Reconstruction Microscopy Imaging Technique and Application. Acta Optica Sinica, 37: 0318005


18.Solid-State Structure of Abeta (Aβ) in Alzheimer’s Disease.

Lu, J.X., Dong X.Q., and Zhang J.J. (2017). Solid-State Structure of Abeta (Aβ) in Alzheimer’s Disease. Protein & Pept Lett 24, 322-330.


19.Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Gurung, P#., Fan, G#., Lukens, J.R., Vogel, P., Tonks, N.K., and Kanneganti, T. D. (2017). Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease. Immunity 46, 635-648.



20.Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint.

Hu, X#., Shen, B #., Liao, S#., Ning, Y., Ma, L., Chen, J., Lin, X., Zhang, D., Li, Z., Zheng, C., Feng, Y., Huang, X*., and Han, C*. (2017). Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint. Cell Death Dis 8, e2910.


21.Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity.

Neef, S., Heijman, J., Otte, K., Dewenter, M., Saadatmand, A.R., Meyer-Roxlau, S., Antos, C.L., Backs, J., Dobrev, D., Wagner, M., Maier, L.S., and El-Armouche, A. (2017). Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol 390, 857-862.


22.A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor.

Ye, L., Ding, K., Zhao, F., Liu, X., Wu, Y., Liu, Y., Xue, D., Zhou, F., Zhang, X., Stevens, R.C., Xu, F., Zhao, S*., and Tao, H*. (2017). A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor. Med Chem Comm 8, 1332-1336.


23.CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms.

Yao, X., Wang, X., Liu, J., Hu, X., Shi, L., Shen, X., Ying, W., Sun, X., Wang, X., Huang, P*., and Yang, H*. (2017). CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms. EBioMedicine 20, 19-26.


24.Critical roles of CTP synthase N-terminal in cytoophidium assembly.

Huang, Y., Wang, J.J., Ghosh, S., and Liu, J.L*. (2017). Critical roles of CTP synthase N-terminal in cytoophidium assembly. Exp Cell Res 354, 122-133.


25.Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Song, G.J., Yang, D.H., Wang, Y.X., de Graaf, C., Zhou, Q.T., Jiang, S.S., Liu, K.W., Cai, X.Q., Dai, A.T., Lin, G.Y., Liu, D.S., Wu, F., Wu, Y.R., Zhao, S.W., Ye, L., Han, G.W., Lau, J., Wu, B.L., Hanson, M.A., Liu, Z.J *., Wang, M.W*., and Stevens, R.C*. (2017). Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature 546, 312-315.


26.Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.

Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., and Xu, F*. (2017). Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nat Commun 8, 15383.


27.Homology-mediated end joining-based targeted integration using CRISPR/Cas9.

Yao, X., Wang, X., Hu, X., Liu, Z., Liu, J., Zhou, H., Shen, X., Wei, Y., Huang, Z., Ying, W., Wang, Y., Nie, Y.H., Zhang, C.C., Li, S., Cheng, L., Wang, Q., Wu, Y., Huang, P., Sun, Q., Shi, L., and Yang, H. (2017). Homology-mediated end joining-based targeted integration using CRISPR/Cas9. Cell Res 27, 801-814.


28.A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from alphaD-Conotoxin GeXXA.

Yang, L., Tae, H.S., Fan, Z., Shao, X., Xu, S., Zhao, S., Adams, D.J*., and Wang, C*. (2017). A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from alphaD-Conotoxin GeXXA. Mar Drugs 15.


29.NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.

Zhou, Z., Kawabe, H., Suzuki, A., Shinmyozu, K., and Saga, Y*. (2017). NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. Nat Commun 8, 15662.


30.Structural Basis for Apelin Control of the Human Apelin Receptor.

Ma, Y., Yue, Y., Ma, Y., Zhang, Q., Zhou, Q., Song, Y., Shen, Y., Li, X., Ma, X., Li, C., Hanson, M.A., Han, G.W., Sickmier, E.A., Swaminath, G., Zhao, S., Stevens, R.C., Hu, L.A., Zhong, W., Zhang, M., and Xu, F*. (2017). Structural Basis for Apelin Control of the Human Apelin Receptor. Structure 25, 858-866.e4.


31.Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.

An, B., Wang, X., Cui, M., Gui, X., Mao, X., Liu, Y., Li, K., Chu, C., Pu, J., Ren, S., Wang, Y., Zhong, G*., Lu, T.K., Liu, C., and Zhong, C. (2017). Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains. ACS Nano 11, 6985-6995.


32.Preexisting endothelial cells mediate cardiac neovascularization after injury.

He, L.J., Huang, X.Z., Kanisicak, O., Li, Y., Wang, Y., Li, Y., Pu, W.J., Liu, Q.Z., Zhang, H., Tian, X.Y., Zhao, H., Liu, X.X., Zhang, S.H., Nie, Y., Hu, S.S., Miao, X., Wang, Q.D., Wang, F.C., Chen, T., Xu, Q.B., Lui, K.O., Molkentin, J.D., and Zhou, B. (2017). Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest 127, 2968-2981.


33.Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.

Li, L., Guo, X., Shi, X., Li, C., Wu, W., Yan, C., Wang, H., Li, H., and Xu, C. (2017). Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci USA 114, E5891-E5899.


34.Crystal structures of agonist-bound human cannabinoid receptor CB1.

Hua, T., Vemuri, K., Nikas, S.P., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Jiang, S., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S*., Bohn, L.M*., Makriyannis, A*., Stevens, R.C., and Liu, Z.J*. (2017). Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature 547, 468-471.


35.3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis.

Ke, Y#., Xu, Y #., Chen, X#., Feng, S#., Liu, Z., Sun, Y., Yao, X., Li, F., Zhu, W., Gao, L., Chen, H., Du, Z., Xie, W., Xu, X., Huang, X*., and Liu, J*. (2017). 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. Cell 170, 367-381.


36.Identification of a hybrid myocardial zone in the mammalian heart after birth.

Tian, X.Y., Li, Y., He, L.J., Zhang, H., Huang, X.Z., Liu, Q.Z., Pu, W.J., Zhang, L.B., Li, Y., Zhao, H., Wang, Z.F., Zhu, J.H., Nie, Y., Hu, S.S., Sedmera, D., Zhong, T.P., Yu, Y., Zhang, L., Yan, Y., Qiao, Z.Y., Wang, Q.D., Wu, S.M., Pu, W.T., Anderson, R.H., and Zhou, B. (2017). Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun 8, 87.


37.Whole-cell Patch-clamp Recordings of Isolated Primary Epithelial Cells from the Epididymis.

Zhang, B.L., Gao, D.Y., Zhang, X.X., Shi, S., and Shum, W*. (2017). Whole-cell Patch-clamp Recordings of Isolated Primary Epithelial Cells from the Epididymis. J Vis Exp.


38.Making human cardiomyocytes up to date: Derivation, maturation state and perspectives.

Kolanowski, T.J., Antos, C.L., and Guan, K. (2017). Making human cardiomyocytes up to date: Derivation, maturation state and perspectives. Int J Cardiol 241, 379-386.


39.Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.

Zhang, H., Huang, X.Z., Liu, K., Tang, J., He, L.J., Pu, W.J., Liu, Q.Z., Li, Y., Tian, X.Y., Wang, Y., Zhang, L.B., Yu, Y., Wang, H.Y., Hu, R.G., Wang, F.C., Chen, T., Wang, Q.D., Qiao, Z.Y., Zhang, L., Lui, K.O., and Zhou, B. (2017). Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res 27, 1157-1177.


40.Building Cre Knockin Rat Lines Using CRISPR/Cas9.

Ma, Y *., Zhang, L., and Huang, X*. (2017). Building Cre Knockin Rat Lines Using CRISPR/Cas9. Methods in Molecular Biology 1642, 37-52.


41.Highly efficient and precise base editing in discarded human tripronuclear embryos.

Li, G#., Liu, Y#., Zeng, Y#., Li, J., Wang, L., Yang, G., Chen, D., Shang, X., Chen, J., Huang, X*., and Liu, J*. (2017). Highly efficient and precise base editing in discarded human tripronuclear embryos. Protein Cell 8, 776-779.


42.Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor.

Wang, L #., Xue, W#., Yan, L #., Li, X., Wei, J., Chen, M., Wu, J., Yang, B*., Yang, L*., and Chen, J*. (2017). Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor. Cell Res 27,1289-1292.


43.APOBEC: From mutator to editor.

Yang, B*., Li, X., Lei, L., and Chen, J*. (2017). APOBEC: From mutator to editor. J Genet Genomics 44,423-437.



44.Key Elements for Designing and Performing a CRISPR-Cas9 based Genetic Screen.

hang, W#., Wang F#., Fan, G.,and Wang H*. (2017). Key Elements for Designing and Performing a CRISPR-Cas9 based Genetic Screen. J Genet Gemomics 44, 439-449.


45.TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.

Luo, J., Shen, W.L., and Montell, C. (2017). TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae. Nat Neurosci 20, 34-41.



46.Chapter 15 - Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies A2 - Tollefsbol, Trygve O.

Mao, S., Li, Y., Liu, B., and Chi, T. (2017). Chapter 15 - Mouse Models of Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies A2 - Tollefsbol, Trygve O. In Handbook of Epigenetics (Second edition) (Academic Press), pp. 231-243.


47.Genomic Tagging of AGO1 using CRISPR/Cas9-mediated Homologous Recombination. In Katsutomo Okamura, Kotaro Nakanishi (eds.), Argonaute Proteins: Methods and Protocols

Ghosh,S.,and Liu, J.L*(2017). Genomic Tagging of AGO1 using CRISPR/Cas9-mediated Homologous Recombination. In Katsutomo Okamura, Kotaro Nakanishi (eds.), Argonaute Proteins: Methods and Protocols, Methods Mole Biol (in press).


48.Pericentral hepatocytes produce IGF-2 to promote liver regeneration during special injuries.

Liu, J., Hu, X., Chen, J., Li, X., Wang, L., Wang, B., Peng, W., Yang, C., Li, Z., Chen, Y., Wang, Y.J., Li, C., Li, X., Yan, F., Wang, Y., Shang, C., Wang, X., Chen, T*., and Huang, P*(2017). Pericentral hepatocytes produce IGF-2 to promote liver regeneration during special injuries. Hepatology (in press).


49.Identification of Natural Products as Novel Ligands for the Human 5- HT2C Receptor.

Peng, Y#., Zhao, S#., Wu, Y., Cao, H. , Xu, Y., Liu, X., Shui, W.Q., Cheng, J.J. , Zhao, S., Shen, L., Ma, J., Quinn, RJ., Stevens, R.C., Zhong, G*.,and Liu, ZJ *. (2017). Identification of Natural Products as Novel Ligands for the Human 5- HT2C Receptor. Biophys Rep (Accepted)


50.Chapter 14 - Lineage-Dependent Electrical Synapse Formation in the Mammalian Neocortex A2 - Jing, Jian.

He, S#., and Shi, S.H. (2017). Chapter 14 - Lineage-Dependent Electrical Synapse Formation in the Mammalian Neocortex A2 - Jing, Jian. In Network Functions and Plasticity (Academic Press), pp. 321-348.


51.Our gut bacteria may act as a foe of our brain.

Zhu, H. (2017). Our gut bacteria may act as a foe of our brain. AME Medical Journal editorial 2, 87.


Achievement in the year of 2016


1.New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16.

Q.F., Ouyang, S.Y*., Cheng, G.H*., and Liu, Z.J*. (2016). New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16. J Mol Cell Biol 8, 51-61.


2.Somatic human ZBTB7A zinc finger mutations promote cancer progression.

Liu, X.S., Liu, Z., Gerarduzzi, C., Choi, D.E., Ganapathy, S., Pandolfi, P.P., and Yuan, Z.M. (2016). Somatic human ZBTB7A zinc finger mutations promote cancer progression. Oncogene 35, 3071-3078.


3.Single-molecule perspectives on helicase mechanisms and functions.

Sun, B., and Wang, M.D. (2016). Single-molecule perspectives on helicase mechanisms and functions. Crit Rev Biochem Mol 51, 15-25.


4.A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis.

Zou, Y., Chintamanani, S., He, P., Fukushige, H., Yu, L., Shao, M., Zhu, L., Hildebrand, D.F., Tang, X., and Zhou, J.M. (2016). A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis. J Integr Plant Biol 58, 600-609.


5.Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development.

Suzuki, A., Niimi, Y., Shinmyozu, K., Zhou, Z., Kiso, M., and Saga, Y*.(2016). Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell developmentEMBO Rep 17, 37-46.


6.Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes.

Shi, X.L#., Gao, Y#., Yan, Y#., Ma, H #., Sun, L #., Huang, P#., Ni, X., Zhang, L., Zhao, X., Ren, H., Hu, D., Zhou, Y., Tian, F., Ji, Y., Cheng, X., Pan, G., Ding, Y.T., and Hui, L. (2016). Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. Cell Res 26, 206-216.


7.H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass.

Fang, L., Zhang, J., Zhang, H., Yang, X., Jin, X., Zhang, L., Skalnik, D.G., Jin, Y., Zhang, Y., Huang, X., Li, J., and Wong, J. (2016). H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells 34, 565- 580.


8.Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types.

Wang, C., Gu, Y., Zhang, K., Xie, K., Zhu, M., Dai, N., Jiang, Y., Guo, X., Liu, M., Dai, J., Wu, L., Jin, G., Ma, H., Jiang, T., Yin, R., Xia, Y., Liu, L., Wang, S., Shen, B., Huo, R., Wang, Q., Xu, L., Yang, L., Huang, X., Shen, H., Sha, J., and Hu, Z. (2016). Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types. Nat Commun 7, 10499.


9.A CRISPR-Based Toolbox for Studying T Cell Signal Transduction.

Chi, S., Weiss, A*., and Wang, H*. (2016). A CRISPR-Based Toolbox for Studying T Cell Signal Transduction. Biomed Res Int 2016, 5052369.


10.Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.

Dong, X., Chiu, H., Park, Y.J., Zou, W., Zou, Y., Ozkan, E., Chang, C., and Shen, K. (2016). Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.eLife 5. e11008


11.Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.

Julien, O*., Zhuang, M*., Wiita, A.P., O'Donoghue, A.J., Knudsen, G.M., Craik, C.S., and Wells, J.A. (2016). Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci USA113, E2001-2010.


12.MLKL forms cation channels.

Xia, B., Fang, S., Chen, X., Hu, H., Chen, P., Wang, H*., and Gao, Z*.(2016). MLKL forms cation channelsCell Res 26, 517-528


13.Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments.

Lu, J.X., Bayro, M.J., and Tycko, R. (2016). Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments. J Biol Chem 291, 13098-13112.


14.Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans.

Ying, L., and Zhu, H*. (2016). Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans. Worm 5, e1184814.


15.An activation-induced IL-15 isoform is a natural antagonist for IL-15 function.

Zhao, L., Hu, B., Zhang, Y., Song, Y., Lin, D., Liu, Y., Mei, Y., Sandikin, D., Sun, W., Zhuang, M., and Liu, H. (2016). An activation-induced IL-15 isoform is a natural antagonist for IL-15 function. Sci Rep 6, 25822.


16.Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger.

Liao, J *#., Marinelli, F*., Lee, C., Huang, Y., Faraldo-Gomez, J.D*., and Jiang, Y *. (2016). Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nat Struct Mol Biol 23, 590-599.


17.Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies.

Carlson, L.A., Bai, Y., Keane, S.C., Doudna, J.A., and Hurley, J.H. (2016). Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. eLife 5,e14663


18.Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase.

He, Q., Wang, F., Liu, S., Zhu, D., Cong, H., Gao, F., Li, B., Wang, H., Lin, Z., Liao, J., and Gu, L. (2016). Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase. J Biol Chem 291, 3668-3681.


19.Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein.

Ma, Y., Chen, W., Zhang, X., Yu, L., Dong, W., Pan, S., Gao, S., Huang, X*., and Zhang, L*. (2016). Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein. RNA Biol 13, 605-612.


20.Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.

Zhao, Y., Zhang, T., Huo, H., Ye, Y., and Liu, Y*.(2016). Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions. J Biol Chem 291, 18252-18262.


21.Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.

Zhang, X., Carter, M.S., Vetting, M.W., San Francisco, B., Zhao, S., Al-Obaidi, N.F., Solbiati, J.O., Thiaville, J.J., de Crecy-Lagard, V., Jacobson, M.P., Almo, S.C., and Gerlt, J.A*.(2016). Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proc Natl Acad Sci USA 113, E4161-4169.


22.Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches.

Fu, X., Wang, Z., Li, L., Dong, S., Li, Z., Jiang, Z., Wang, Y., and Shui, W*.(2016). Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometry and Metabolomics Approaches. Sci Rep 6, 29680.


23.TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.

Ke, Q., Li, W., Lai, X., Chen, H., Huang, L., Kang, Z., Li, K., Ren, J., Lin, X., Zheng, H., Huang, W., Ma, Y., Xu, D., Chen, Z., Song, X., Lin, X., Zhuang, M., Wang, T., Zhuang, F., Xi, J., Mao, F.F., Xia, H., Lahn, B.T., Zhou, Q., Yang, S., and Xiang, A.P. (2016). TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res 26, 1048-1061.


24.Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis.

Gao da, Y., Zhang, B.L., Leung, M.C., Au, S.C., Wong, P.Y., and Shum, W*. (2016). Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis. J Gen Physiol 148, 161-182.


25.Antigen Receptor Nanoclusters: Small Units with Big Functions.

Liu, W., Wang, H., and Xu, C. (2016). Antigen Receptor Nanoclusters: Small Units with Big Functions. Trends Immunol 37, 680-689.


26.Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep.

Wang, X#., Niu, Y#., Zhou, J#., Yu, H#., Kou, Q., Lei, A., Zhao, X., Yan, H., Cai, B., Shen, Q., Zhou, S., Zhu, H., Zhou, G., Niu, W., Hua, J., Jiang, Y., Huang, X*., Ma, B*., and Chen, Y*. (2016). Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep. Sci Rep 6, 32271.


27.Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.

Wu, Q., Fukuda, K., Kato, Y., Zhou, Z., Deng, C.X., and Saga, Y*.(2016). Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming. PLoS Biol 14, e1002553.


28.SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

Koledova, Z., Zhang, X., Streuli, C., Clarke, R.B., Klein, O.D., Werb, Z., and Lu, P*. (2016). SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci USA113, E5731-5740.


29.Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase.

Hill, Z.B., Pollock, S.B., Zhuang, M., and Wells, J.A. (2016). Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 LigaseJ Am Chem Soc138, 13123-13126.


30.The Cytoophidium and Its Kind: Filamentation and Compartmentation of Metabolic Enzymes.

Liu, J.L*. (2016). The Cytoophidium and Its Kind: Filamentation and Compartmentation of Metabolic Enzymes. Annu Rev Cell Dev Biol32, 349-372.


31.Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer.

Huang, P., Li, B., and Zheng, Y.-W. (2016). Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer. In Stem Cells in Toxicology and Medicine (John Wiley & Sons, Ltd), pp. 363-374.


32.Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System.

Hu, R., Jin, S., He, X., Xu, F., and Hu, J*. (2016).Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System. Front Neuroanat 10, 98.


33.Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.

Schulze-Gahmen, U., Echeverria, I., Stjepanovic, G., Bai, Y., Lu, H., Schneidman-Duhovny, D., Doudna, J.A., Zhou, Q., Sali, A., and Hurley, J.H. (2016). Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.eLife 5, e15910.


34.Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.

Gerarduzzi, C., de Polo, A., Liu, X.S., El Kharbili, M., Little, J.B., and Yuan, Z.M. (2016). Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. J Biol Chem 291, 25937-25949.


35.Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia.

Yao, L., Lu, P., and Ling, E.A. (2016). Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia. PLoS One 11, e0166010.


36.Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration.

Pu, W., Zhang, H., Huang, X., Tian, X., He, L., Wang, Y., Zhang, L., Liu, Q., Li, Y., Li, Y., Zhao, H., Liu, K., Lu, J., Zhou, Y., Huang, P., Nie, Y., Yan, Y., Hui, L., Lui, K.O., and Zhou, B. (2016). Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun 7, 13369.


37.Efficient generation of B2m-null pigs via injection of zygote with TALENs.

Wang, Y#., Du, Y#., Zhou, X., Wang, L., Li, J., Wang, F., Huang, Z., Huang, X *., and Wei, H*. (2016). Efficient generation of B2m-null pigs via injection of zygote with TALENs. Sci Rep 6, 38854.



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