Wenqing Shui    Assistant Professor, PI
InstituteSchool of Life Science and Technology
iHuman  Institute
Research AreaBio-mass spectrometry and Omics Technology
Contact Info.shuiwq@@shanghaitech.edu.cn

Dr. Wenqing Shui graduated from Fudan  University (Shanghai, China) with a master degree in 2004 and received Ph.D. at  University of California (Berkeley, U.S.A.) with Dr. Carolyn Bertozzi and Dr.  Jay Keasling in 2009. After her postdoctoral training at Thermo Fisher  Scientific (San Jose, USA) as a bio-mass spectrometry application scientist, she  joined School of Life Sciences in Nankai University (Tianjin, China) as  Associate Professor from 2010 to 2015. During 2013-2015,she was Joint PI at  Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of  Sciences. Then she joined TIB as PI from 2015 to 2016. Since April 2016, she  joined ShanghaiTech university as an assistant professor at school of life  science and technology and as a research associate professor(PI) at iHuman  institute.

Research  Interests
The main goal of Shui research group is to  develop versatile mass spectrometry (MS)-based technologies for GPCR ligand  discovery and cell signaling study. Over the years, our group has gained  extensive experiences in developing high resolution mass spectrometry-centered  analytical pipelines for comprehensive or targeted protein and metabolite  analysis. Our expertise in proteomics and metabolomics research has been  exploited to establish affinity mass spectrometry technology for ligand  screening towards protein targets of therapeutic importance. These new  approaches have unique advantages in building a high-throughput screening  platform for early-phase drug discovery as well as probing receptor-drug  interactions and signaling selectivity within the cell.

Shui laboratory website: http://group.ihuman-institute.org/shuilab/

Selected  Publications

1. Qin S, Meng M, Yang D,  et al., Wang MW*, Stevens RC, Shui W*. High-throughput  Identification of G Protein-coupled Receptor Modulators through Affinity Mass  Spectrometry Screening. Chemical Science 2018, 9, 3192-3199. 

2. Wang X, Li S, Wang H, Shui W*, Hu J*.  Quantitative Proteomics Reveal Proteins Enriched in Tubular Endoplasmic  Reticulum of Saccharomyces cerevisiae. Elife 2017, 6, e23816.

3. Fu X, Wang Z, Li L, Dong S,Li Z, Jiang Z,  Wang Y, Shui W*. Novel Chemical Ligands to Ebola Virus and Marburg Virus  Nucleoproteins Identified by Combining Affinity Mass Spectrometryand  Metabolomics Approaches. Scientific Reports. 2016, 6, 29680.

4. Li Z, Li Y, Chen W, et al., Shui  W*. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction  Monitoring Assays for Targeted Metabolite Quantification and Dynamic  13C-Labeling Metabolism Analysis. Analytical Chemistry 2017, 89, 1,  877-885.

5. Xiong Y, Guo Y, Xiao W, Cao Q, Li S, Qi X,  Zhang Z, Wang Q*, Shui W*. An NGS-Independent Strategy for Proteome-Wide  Identification of Single Amino Acid Polymorphisms by Mass  Spectrometry. Analytical Chemistry 2016, 88, 5, 2784-2791.

6. Chen X, Li L, Chen S, et al., Shui  W*. Identification of Inhibitors of the Antibiotic-Resistance Target New Delhi  Metallo-β-lactamase 1 by both Nanoelectrospray Ionization Mass Spectrometry and  Ultrafiltration-LC/MS Approaches. Analytical Chemistry 2013, 85,  7957-7965.

7.Yan L, Ma Y, Liu D, Wei X, Sun  Y, Chen X, Zhao H, Zhou J, Wang Z, Shui W*, Lou Z*. Structural basis for the  impact of phosphorylation on plant receptor-like kinase BAK1 activation. Cell  Research 2012, 8, 1304-1308.