|Dr. Wenqing Shui graduated from Fudan University (Shanghai, China) with a master degree in 2004 and received Ph.D. at University of California (Berkeley, U.S.A.) with Dr. Carolyn Bertozzi and Dr. Jay Keasling in 2009. After her postdoctoral training at Thermo Fisher Scientific (San Jose, USA) as a bio-mass spectrometry application scientist, she joined School of Life Sciences in Nankai University (Tianjin, China) as Associate Professor from 2010 to 2015. During 2013-2015，she was Joint PI at Tianjin Institute of Industrial Biotechnology (TIB), Chinese Academy of Sciences. Then she joined TIB as PI from 2015 to 2016. Since April 2016, she joined ShanghaiTech university as an assistant professor at school of life science and technology and as a research associate professor(PI) at iHuman institute.|
|The main goal of Shui research group is to develop versatile mass spectrometry (MS)-based technologies for GPCR ligand discovery and cell signaling study. Over the years, our group has gained extensive experiences in developing high resolution mass spectrometry-centered analytical pipelines for comprehensive or targeted protein and metabolite analysis. Our expertise in proteomics and metabolomics research has been exploited to establish affinity mass spectrometry technology for ligand screening towards protein targets of therapeutic importance. These new approaches have unique advantages in building a high-throughput screening platform for early-phase drug discovery as well as probing receptor-drug interactions and signaling selectivity within the cell. |
Shui laboratory website: http://group.ihuman-institute.org/shuilab/
1. Qin S, Meng M, Yang D, et al., Wang MW*, Stevens RC, Shui W*. High-throughput Identification of G Protein-coupled Receptor Modulators through Affinity Mass Spectrometry Screening. Chemical Science 2018, 9, 3192-3199.
2. Wang X, Li S, Wang H, Shui W*, Hu J*. Quantitative Proteomics Reveal Proteins Enriched in Tubular Endoplasmic Reticulum of Saccharomyces cerevisiae. Elife 2017, 6, e23816.
3. Fu X, Wang Z, Li L, Dong S,Li Z, Jiang Z, Wang Y, Shui W*. Novel Chemical Ligands to Ebola Virus and Marburg Virus Nucleoproteins Identified by Combining Affinity Mass Spectrometryand Metabolomics Approaches. Scientific Reports. 2016, 6, 29680.
4. Li Z, Li Y, Chen W, et al., Shui W*. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis. Analytical Chemistry 2017, 89, 1, 877-885.
5. Xiong Y, Guo Y, Xiao W, Cao Q, Li S, Qi X, Zhang Z, Wang Q*, Shui W*. An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry. Analytical Chemistry 2016, 88, 5, 2784-2791.
6. Chen X, Li L, Chen S, et al., Shui W*. Identiﬁcation of Inhibitors of the Antibiotic-Resistance Target New Delhi Metallo-β-lactamase 1 by both Nanoelectrospray Ionization Mass Spectrometry and Ultrafiltration-LC/MS Approaches. Analytical Chemistry 2013, 85, 7957-7965.
7.Yan L, Ma Y, Liu D, Wei X, Sun Y, Chen X, Zhao H, Zhou J, Wang Z, Shui W*, Lou Z*. Structural basis for the impact of phosphorylation on plant receptor-like kinase BAK1 activation. Cell Research 2012, 8, 1304-1308.