Jianlong Sun    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaStem cell biology
Contact Info.sunjl@@shanghaitech.edu.cn


Biography
Dr. Sun graduated from Fudan University in 1999 with a Bachelor’s degree in Biology and received his Ph.D. in Molecular Medicine from the University of Texas Health Science Center at San Antonio (UTHSCSA) in 2009. Dr. Sun was a postdoctoral fellow at UTHSCA from 2009 to 2010. In 2010, Dr. Sun joined Dr. Fernando Camargo’s laboratory at Boston Children’s Hospital and Harvard University, where he worked as a postdoctoral research fellow until 2017. Dr. Sun joined Shanghaitech University in 2017, and currently, he is a tenure-track Assistant Professor in the School of Life Science and Technology.

Research Interests
Our group is interested in understanding the cellular and molecular mechanisms that control self-renewal and differentiation of tissue resident stem cells. We aim to determine how these mechanisms are bypassed or hijacked in the process of neoplastic transformation, and how these mechanisms can be harnessed to improve stem cell regeneration for clinical implications. Using the hematopoietic system as a model, we track the clonal dynamics and differentiation of stem and progenitor cells in situ under a variety of physiological conditions. We also use cutting-edge technologies, including insertional mutagenesis and genome editing, to uncover the molecular networks that dictate the clonal behaviors of the individual stem and progenitor cells. Last but not least, we explore how disease-associated genetic and cellular alterations affect the normal clonal behaviors, thereby providing new insights into the etiology of hematopoietic diseases.

Selected Publications
1.Sun J, Ramos A, Chapman B, Johnnidis J, Le L, Ho Y, Klein A, Hofmann O, Camargo FD (2014) Clonal dynamics of native hematopoiesis. Nature 514(7522):322-327

2.Mohseni M, Sun J, Lau A, Curtis S, Goldsmith J, Fox VL, Wei C, Frazier M, Samson O, Wong KK, Kim C, Camargo FD (2014) A genetic screen identifies an LKB1/PAR1 signaling axis controlling the Hippo/YAP pathway. Nat Cell Biol 16(1):108-117 

3.Sun J*, Pan H*, Lei C, Yuan B, Nair SJ, April C, Parameswaran B, Klotzle B, Fan JB, Ruan J, Li R. (2011) Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth. J Biol Chem 286(42):36248-36257 (* co-first author)

4.Sun J, Li R (2010) Human Negative Elongation Factor (NELF) activates transcription and regulates alternative transcription initiation. J Biol Chem 285(9):6443-6452

5.Aiyar SE, Sun J, Blair AL, Moskaluk CA, Lv Y, Ye Q-N, Yamaguchi Y, Mukherjee A, Ren D- M, Handa H, Li R. (2004) Attenuation of estrogen receptor a-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes & Dev 18:2134-2146


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