Haopeng Wang    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaT Cell Activation and Costimulation
Contact Info.wanghp@@shanghaitech.edu.cn

Dr. Haopeng Wang graduated from Department for Intensive Instruction, Nanjing University in 2003. Dr. Wang conducted his graduate research in the Department of Immunology at St Jude Children’s Research Hospital and obtained his Ph.D. degree from The University of Tennessee Health Science Center in 2009. From 2009-2015, he obtained his postdoctoral training in the Department of Immunology at University of California San Francisco. Since July 2015, Dr. Wang joined ShanghaiTech University as a tenure-track assistant professor, PI in the School of Life Sciences and Technology. Dr. Wang was selected to the “1000 Talents Program for Distinguished Young Scholars” in 2015.

Research Interests
T cells are a vital component of the adaptive immune system. T cell activation is tightly regulated to ensure T cells provide an appropriate response to a broad array of antigens, including infectious agents that the host might encounter and tumor antigens inside of tumor, as well as self-antigens within the body. Impaired signal transduction in T cells could leads into immune deficiency, autoimmune diseases or defective cancer immune surveillance. Our lab aims to use a multidisciplinary approach to achieve a better understanding of T cell signaling pathways, which would be beneficial for the development of therapeutic strategies for immune disorders and cancer immunotherapy.

Selected Publications
  1. Tian R*, Wang H*, Pasculescu A, Shi Y, Gish G, Hunter T, Gingras A, Pawson T, Weiss A. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor PNAS 2015 12; 1594-1603 (*equal contribution)

  2. Punwani D*Wang H*, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined Immunodeficiency due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation.  J Clin. Immunol. 2015 35 135-146(* equal contribution)

  3. Wang H*, Flach H*, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1α expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nature Immunology 2014 15; 393–401 (* equal contribution)

  4. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA.Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator. Molecular Cell. 2013 49(2):273-82.

  5. Wang H,Kadlecek T, Au-Yeung B, Sjölin Goodfellow H, Hsu LY, Freedman T, Weiss A.ZAP-70: an essential kinase in T cell signaling. Cold Spring Harb Perspect Biol2010 1;2(5).

  6. Wang H, Holst J, Woo S, Guy CS, Bettni M, Wang Y, Aaron S, Naramura M, Mingueneau M, Dragone L, Hayes S, Malissen B, Band H, Vignali DA. Tonic Ubiquitylation controls T cell receptor:CD3 complex expression during T cell development. EMBO J. 2010 7;29(7):1285-98.

  7. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholsonll TP, Sheppardll PW, Haecker H, Karin M, Vignali DA. Analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for K63-linked polyubiqutin. PNAS 2008 105(51):20197-202.

  8. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nature Immunology 2008 9(12):1364-70.

  9. Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology 2008 9(6):658-66.

  10. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008 321(5889):663-8