Fei Xu    Assistant Professor, PI
InstituteSchool of Life Science and Technology
iHuman Institute
Research Areastructural biology
Contact Info.xufei@@shanghaitech.edu.cn

-Aug 2014- present Assistant Professor(Tenure-track), PI, School of Life Science and Technology, ShanghaiTech University -Sept 2013- present Research Associate Professor,Principle Investigator, iHuman Institute, ShanghaiTech University Focused on GPCR signaling in stem cell development and cancer -Sept 2012- Sept 2013 Scientific Consultant, RuiYi Inc., La Jolla, CA, USA -Aug 2011- Sept 2012 Founder and Director, R&D RuiYi Biopharmaceutics Technology Co., Ltd., Shanghai, China Focused on biologic drug development targeting on GPCR -July 2006- June 2011 Ph.D. in Biology The Scripps Research Institute (TSRI), La Jolla, California, USA -Sept 2002- July 2006 B.S. in Biological Sciences University of Science and Technology of China (USTC), Hefei, China Research Interests Research interests include deciphering the signaling pathways of G-protein coupled receptor (GPCR) in human cells, with an emphasis on GPCR signaling in developmental biology. My lab will employ the cutting-edge technologies in GPCR area and leverage extensive collaborations with other research groups to explore the critical involvement of GPCRs in embryogenesis and tissue homeostasis regulation, and the direct relevance of dysregulation of GPCR signaling to numerous human diseases.

Selected Publications

1. Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, Hanson MA, Cherezov V, Stevens RC, Tan W, Tao H, Xu F. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand”Nature Communications, 8:15383, (2017)

2. Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F. Structural Basis for Apelin Control of the Human Apelin Receptor” Structure, doi: 10.1016/j.str.2017.04.008, (2017)

3. Zhang X, Stevens RC, Xu F. The importance of ligands for G protein-coupled receptor stability Trends Biochem Sci. 40(2):79-87, (2015)

4. Liu W, Chun E, Thompson A.A, Chubukov P, Xu F, Katritch V, Han G-W, Roth C.B, Heitman L.H, Ijzerman A.P, Cherezov V, Stevens R.C. “Structural basis for allosteric regulation of GPCRs by sodium ions” Science, 337(6091): 232-236, (2012)

5. Chun E, Thompson A.A, Liu W, Roth C.B, Griffith M.T., Katritch V, Kunken J, Xu F, Cherezov V, Hanson M.A, Stevens R.C. “Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors” Structure, 20(6): 967-976, (2012)

6. Tosh D.K, Phan K, Gao Z-G, Gakh A.A, Xu F, Deflorian F, Abagyan R, Stevens R.C, Jacobson K.A, Katritch V. “Optimization of Adenosine 5’ -Carboxamide Derivatives as Adenosine Receptor Agonists Using Structure-Based Ligand Design and Fragment-Based Searching” J Med Chem, 55(9): 4297-4308, (2012)

7. Deflorian F, Kumar TS, Phan K, Gao Z-G, Xu F, Wu H, Katritch V, Stevens R.C, Jacobson K.A. “Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A(2A) Adenosine Receptor” J Med Chem, 55(1): 538-552, (2012)

8. Xu F, Stevens R.C. “Trapping small caffeine in a large GPCR pocket” Structure, 19(9): 1204-1207, (2011) Invited Review.

9. Xu F, Wu H, Katritch V, Han G-W, Jacobson K.A, Gao Z-G, Cherezov V, Stevens R.C. “Structure of an agonist-bound human A2A adenosine receptor” Science, 332: 322-327, (2011)

10. Xu F, Liu W, Hanson M, Stevens R.C, Cherezov V. “Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases” Crystal Growth & Design, 11(4): 1193-1201, (2011)