Hui Zhang    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaHeart development and regeneration


2004.09-2008.06, B.A. in College of Animal Sciences and Technology, Huazhong Agricultural University

2008.09-2014.03, Ph.D. in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

2014.04-2016.03, Postdoc in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

2016.04-2016.10, Research fellow in Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

2016.11 to Present, PI in School of Life Science and Technology, ShanghaiTech University.

Research Interests

1. To investigate the mechanisms regulating cardiac development and neonatal heart regeneration in mice and develop new strategies for promoting adult heart regeneration and repair after injury.

2. To study the cell fate conversions in development and diseases of multiple organs (heart, liver, lung and others) using genetic lineage tracing.

Selected Publications

1. Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau L, Zhou B*, Zhang H*. CCN1-induced cellular senescence promotes heart regeneration. Circulation. 2019;139:2495-2498

2. Huang X, Feng T, Jiang Z, Meng J, Kou S, Lu Z, Chen W, Lin C, Zhou B, Zhang H*. Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells, and adipocytes. J Biol Chem. 2019;294:8894-8906

3. Zhang H*, Lui K*, Zhou B*. Endocardial cell plasticity in cardiac development, diseases and regeneration. Circulation research. 2018;122(5):774-789

4. Zhang H#*, Huang X#, Liu K#, Tang J#, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang Q, Qiao Z, Zhang L, Lui K, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell research. 2017;27(9):1075-1090

5. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B*. Endocardium minimally contributes to coronary endothelium in the embryonic ventricular free walls. Circulation research. 2016;118:1880-1893 (cover story)

6. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B*. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nature genetics. 2016;48:537-543

7. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B*. Endocardium contributes to cardiac fat. Circulation research. 2016;118:254-265

8. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B*. Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion. J Biol Chem. 2014;289:18681-18692

9. Tian X#, Hu T#, Zhang H#, He L#, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B*. De novo formation of a distinct coronary vascular population in neonatal heart. Science. 2014;345:90-94

10. Tian X#, Hu T#, Zhang H#, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B*. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell research. 2013;23:1075-1090 (cover story)

(# First author;*Corresponding author)