|2004B. En in Polymer Physics, University of Science and Technology of China, Hefei, China. Advisor: Qing-Xiang Guo |
2009Ph.D in Chemistry, Columbia University, New York, United States. Advisor: Richard A. Friesner
2010-2014Postdoctoral Scholar, Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, United States. Advisor: Matthew P. Jacobson
2014-presentResearch Associate Professor, PI at iHuman Institute, Assistant Professor at School of Life Science and Technology, ShanghaiTech University, Shanghai, China
|Predicting the full-length structures of multi-domain GPCRs |
Discovering ligands for GPCRs and other proteins in cell signaling pathways
| S. Zhao, R. Kumar, A. Sakai, M. W. Vetting, B. M. Wood, S. Brown, J. B. Bonanno, B. S. Hillerich, R. D. Seidel, P. C. Babbitt, S. C. Almo, J. V. Sweedler, J. A. Gerlt, J. E. Cronan, and M. P. Jacobson, “Discovery of new enzymes and metabolic pathways by using structure and genome context”, Nature, 502, 698-702 (2013).|
 S. Zhao, A. Sakai, X. Zhang, M. W. Vetting, R. Kumar, B. Hillerich, B. San Francisco, J. Solbiati, A. Steves, S. Brown, E. Akiva, A. Barber, R. D. Seidel, P. C. Babbitt, S. C. Almo, J. A. Gerlt and M. P. Jacobson, “Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks”, eLife, e03275 (2014).
 M. P. Jacobson, C. Kalyanaraman, S. Zhao and B. Tian, “Leveraging structure for enzyme function prediction: methods, opportunities, and challenges”, Trends Biochem. Sci.,39(8), 363-71 (2014).
 R. Kumar, S. Zhao, A. Sakai, M. W. Vetting, B. M. Wood, S. C. Almo, J. V. Sweedler, J. A. Gerlt, J. E. Cronan, and M. P. Jacobson, “Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant, proline betaine”, mBio,5, (2014).
 S. Zhao, K. Zhu, J. Li, R. A. Friesner, “Progress in super long loop prediction”, Proteins, 79, 2920-2935 (2011).