Zhi Zhou    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaMammalian germ cell development
Contact Info.zhouzhi@@shanghaitech.edu.cn

Dr. Zhi Zhou obtained his bachelor's degree at Department of Animal Science, Hunan Agricultural University in 2005 and then obtained his Ph. D. at Institute of Zoology, Chinese Academy of Sciences in 2011. From 2011-2016, Dr. Zhou received his postdoctoral training in National Institute of Genetics, Japan. Since October, 2016, Dr. Zhou joined ShanghaiTech University as a tenure-track assistant professor, PI in School of Life Sciences and Technology.

Research Interests
Failure of gametogenesis causes clinical infertility; our current interests focus on germ cell development, a) by using spermatogonial stem cell model, we would like to uncover the mechanisms of adult stem cell maintenance and differentiation; b) by using transgenic mouse model, we are trying to figure out the functions of some new genes during meiosis and their working mechanisms.

Selected Publications

Zhi Zhou, Hiroshi Kawabe, Atsushi Suzuki, Kaori Shinmyozu , Yumiko Saga*. NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. Nature Communications, 2017 Jun 6;8:15662.

Zhou Zhi, Takayuki Shirakawa, Kazuyuki Ohbo, Aiko Sada, Wu Quan, Kazuteru Hasegawa, Rie Saba, Yumiko Saga*. The RNA binding protein Nanos2 organizes a post-transcriptional buffering system to maintain the primitive status of mouse spermatogonial stem cells. Developmental Cell, 34, 96–107 July 6, 2015.

3 Atsushi Suzuki, Yuki Niimi, Kaori Shinmyozu, Zhou Zhi, Makoto Kiso, Yumiko Saga*.Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO reports (2016) 17, 37-46.

4 Wu Q, Fukuda K, Kato Y, Zhou Z, Deng CX, Saga Y*. Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming. PLoS Biol, 2016 Sep 8;14(9):e1002553.

Zhou Zhi, Zhang Q, Lu XY, Wang R, Wang H, Wang YL, Zhu C, Lin HY*, Wang H*. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis, 2013, 4, e593.

Zhou Zhi, R Wang, X Yang, X-Y Lu, Q Zhang, Y-L Wang, H Wang, C Zhu, H-Y Lin, H Wang*. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta 2014 Nov 7;35(11):907-18. Epub 2014 Aug 7.

7 Zhang Q, Chen Q, Lu XY, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y*, Wang H*. CUL1 promotes trophoblast cell invasion at the maternal-fetal interface. Cell Death Dis, 2013, 4, e502.

Zhou Zhi, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ*, Wang H*. The proprotein convertase furin in human trophoblast: possible role in promoting trophoblast cell migration and invasion. Placenta. 2009 30(11):929-938.