Huanhu Zhu    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaLipid related function study

Dr. Huanhu Zhu obtained his bachelor and doctor degrees from Fudan University. He studied the functions of lipids and proteins that suppress tumor growth and metastasis in Drosophila melanogaster under his Ph.D. advisors Dr. Tian Xu and Dr. Xiaohui Wu (Fudan Univ.). He then joined Dr. Min Han’s lab (HHMI/Univ. of Colorado, Boulder) in 2010 to further understand how branched-chain lipids regulate development and physiological functions in Caenorhabditis elegans. Since October 2015, Dr. Huanhu Zhu joined School of Life Science and Technology of ShanghaiTech University as an assistant professor, PI.

Research Interests
Lipids are essential nutrients for human and animal survival. By using the model organisms Caenorhabditis elegans and Drosophila melanogaster, and integrating genetics, cell biology, biochemistry and lipidomics, we are interested in (1) How specific fatty acids and related high order lipid molecules regulate signaling transduction pathways and cellular processes to function in development, disease, behavior and other physiological functions. (2) How certain lipid molecules serve as nutrient cues to regulate animal development and metabolism. We currently focus on multiple functional studies of monomethyl branched-chain fatty acids and the downstream product monomethyl branched-chain sphingolipids.

Homepage of Zhu

Selected Publications

1. H Zhu*#, AK Sewell*, and M Han. Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegansGenes & Development, 2015 Jun 15;29(12):1218-23

2. M Kniazeva, H Zhu and M Han#. A lipid-TORC1 pathway promotes neuronal development and functions involved in food responses in C. elegansDevelopmental Cell, 2015 May 4;33(3):260-71.

3. H Zhu# and M Han. Exploring developmental and physiological functions of fatty acid and lipid variants through worm and fly genetics. Annual Review of Genetics, 2014;48:119-48. doi: 10.1146/annurev-genet-041814-095928.

4. H Zhu, H Shen, AK Sewell, M Kniazeva, M Han#. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis eleganseLife. 2013 May 21;2:e00429.

5. C Chi*, H Zhu*, M Han, Y Zhuang, X Wu, T Xu#. Disruption of lysosome function promotes tumor growth and metastasis in DrosophilaJ Biol Chem. 2010 Jul 9;285(28):21817-23.