|Dr. Lin received his BS degree from Fudan University (1982), and his Ph.D. degree from Cornell University (1990). Following his postdoctoral research at the Carnegie Institution of Washington, he joined the faculty of Duke University Medical School in 1994, where he rose to the rank of Full Professor. He founded and directed the Duke Stem Cell Research Program (2005-2006), and moved to Yale in 2006, where he founded and serves as Director of the Yale Stem Cell Center. He is also Professor of Cell Biology, of Genetics, and of Obstetrics, Gynecology & Reproductive Sciences. He joined ShanghaiTech University in 2013 as Professor-in-Residence of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Founding Dean (Adjunct) of School of Life Science and Technology since 2014.|
|RNA-mediated epigenetic programming and post-transcriptional regulation of stem cells|
|1. Ross, R., J.*, Weiner, M. M.*, and Lin, H. (2014) PIWI Proteins and PIWI-interacting RNAs in the Soma. Nature 505, 353-359. (*co-first authors).|
2. Juliano, C. E., Reich, A., Liu, N., Uman, S., Wessel, G., W., Steele, R. E., and Lin, H. (2013) Analysis of the PIWI-piRNA pathway in Hydra somatic stem cells. PNAS .111, 337-342.
3. Mani, S. R*, Megosh, H * and Lin, H. (2013) PIWI proteins are essential for early Drosophila embryogenesis. Developmental Biology 385, 340-349. (*co-first authors).
4. Chang, E. and Lin, H. (2013) Repressing the repressor: a role of a lincRNA in embryonic stem cell self-renewal. Developmental Cell 25:1-2.
5. Saxe, J. P., Chen, M., Zhao, H., and Lin, H. (2013) Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J. 32, 1869-1885.
6.Huang, X. A. *, Yin*, H., Sweeney, S., Raha, D., Snyder, M. and Lin, H. (2013) A major epigenetic programming mechanism guided by piRNAs. Developmental Cell 24 :502-516 (*co-first authors ; Featured Article).
7. Darricarrère, N., Liu, N., Watanabe, T., and Lin, H. (2013) The function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity, PNAS 110:1297-1302.
8. Nolde, M.J., Cheng E.-C., Guo, S., Lin, H. (2013) Piwi genes are dispensable for normal hematopoiesis in mice. PLoS ONE 8: e71950. doi:10.1371/ journal. pone.0071950.
9. Peng, J. and Lin, H. (2013) Beyond Transposons: the Epigenetic and Somatic Functions of the Piwi-piRNA Mechanism. Current Opinion in Cell Biology 25, 190–194.
10. Yin, H., Lin, H. (2013) Small RNA Discovery and Expression Analysis by High throughput Sequencing. In Genomic analysis using high-throughput sequencing (eds. Snyder, M. et al.) Cold Spring Harbor Laboratory Press. pp1-12.