Zhijie Liu    Professor
InstituteSchool of Life Science and Technology
iHuman Institute
Research Areastructural biology
Contact Info.liuzhj@@shanghaitech.edu.cn


Biography
1984 B.Sc. in Physics, Tianjin Normal University, China
1987 M.Sc. in Quantum Chemistry and Physical Chemistry, Tianjin University
1994 Ph.D. in Protein Crystallography, Institute of Biophysics, Chinese Academy of Sciences
1995-1995 Postdoctoral Fellow, Department of Crystallography, University of Pittsburgh
1995-1997 Postdoctoral Fellow, Department of Biochemistry & Molecular Biology, University of Georgia
1997-2002 Assistant Research Scientist, Department of Biochemistry & Molecular Biology, University of Georgia
2002-2005 Associate Research Scientist,Southeast Collaboratory for Structural Genomics (SECSG), Department of Biochemistry & Molecular Biology, University of Georgia
2005–2013 Professor, Institute of Biophysics, Chinese Academy of Sciences
2013–PresentiHuman Institute, ShanghaiTech University

Research Interests
(1) Structural and functional analysis of proteins and multi-protein complexes in innate immune signaling pathway; (2) Structural proteomics of human liver disease related proteins and structure based drug design; (3) Development of new methods and new technologies in protein X-ray crystallography.

Selected Publications

1)X. Li, T. Hua, K. Vemuri, S. J. Ho, Y. Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, GW. Han, M. Iyer, R. Cinar, N. Coffey, J. Wang, M., Wu, V. Katritch, S. Zhao, G. Kunos, L. Bohn, A. Makriyannis, R Stevens. Liu ZJ* (2018) Crystal Structure of the Human Cannabinoid Receptor CB2. Cell, in press. 

2)Y. Peng, J, McCorvy, K, Harpsøe, K Lansu, S Yuan, P Popov, L Qu, M Pu, T Che, L Nikolajsen, X Huang, Y Wu, L Shen, W E. Yoshimoto, K Ding, D Wacker, G Han, J Cheng, V Katritch, A A. Jensen, M. Hanson, S Zhao, D E. Gloriam, B L. Roth*, R C. Stevens*, Liu ZJ*, (2018) The Studies of 5-HT2C Receptor Reveal the Structural Basis of GPCR Polypharmacology.Cell, 172(4):719-730. 

3)T. Hua, K. Vemuri, S. Nikas, R. Laprairie, Y. Wu, L. Qu, M. Pu, A. Korde, S. Jiang, J.H. Ho, GW. Han, D. Ding, X. Li, H. Liu, S. M. Hanson, S. Zhao*, L. Bohn*, A. Makriyannis*, R Stevens. Liu ZJ* (2017) Crystal Structure of agonist-bound Human Cannabinoid Receptor CB1. Nature, 547 (7664): 468-471 

4)Song G, Yang D, Wang Y, Graaf C.D, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, Han G.W, Lau J, Wu B, Hanson M.A, Liu ZJ*, Wang M.W*, and Steven R.C* (2017) Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Nature, 546(7657):312-315.

5)T. Hua, K. Vemuri, M. Pu, L. Qu, GW. Han, Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N. Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn*, A. Makriyannis*, R. Stevens*, Liu ZJ* (2016) Crystal Structure of the Human Cannabinoid Receptor CB1. Cell, 167(3):750-762.

6)Liu B, Ouyang S, Makarova K, Xia Q, Zhu Y, Li Z, Guo L, Koonin E, Liu ZJ*, Huang L*. (2015) A primase subunit essential for efficient primer synthesis by an archaeal eukaryal-type primase. Nat Commun. 6: 7300.

7)J. Gu, Y. Feng, X. Feng, C. Sun, L. Lei, W. Ding, F. Niu, L. Jiao, M. Yang, Y. Li, X. Liu, J. Song, Z. Cui, D. Han, C. Du, Y. Yang, S. Ouyang*, Liu ZJ*, W. Han*, (2014) Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented EF-Hand-Like Calcium-Binding Phage Lysin, PLOS Pathogens, 10(5) e1004109.

8)Zhao, L., Hua, t., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L., Ye, K., OuYang, S*, Cheng, G*, and Liu ZJ*, (2014) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage, Cell Res, 24(3):344-58

9)Niu, F., Shaw, N., Wang, Y., Jiao, L., Ding, W., Li, X., Zhu, P., Upur, H., OuYang, S*, Cheng, G*, and Liu ZJ*, (2013) Structure of the Leanyer Orthobunyavirus Nucleoprotein-RNA complex reveals novel architecture for RNA encapsidation, PNAS, 110(22):9054-9.

10)Ru, H., Ni, X. , Zhao, L. , Crowley, C., Ding, W., Hung, L., Shaw, N., Cheng, G*. and Liu ZJ*, (2013) Structural basis for termination of AIM2-mediated signaling by p202. Cell Res, 23(6):855-8. 

11)OuYang, S, Song, X, Wang, Y, Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Parvatiyar, K., Li, Y., Zhang, R., Cheng, G*., and Liu ZJ*, (2012) Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding, Immunity, 36(6): 1073-1086.

12)Wu, D., Li, Y., Song, GJ, Zhang, R., Joachimiak, A., Shaw, N., & Liu ZJ*. (2009) Structural basis for the inhibition of human MTHFS by N10-substituted folate analogues. Cancer Research, 69(18), 7294-301. (Cover)

13)Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., Liu ZJ*., Wang, B. C. & Rao, Z. (2007) The multifunctional human p100 protein 'hooks' methylated ligands. Nat Struct Mol Biol, 14(8), 779-84.

14)Shaw, N., Cheng, C., and Liu ZJ*, (2007) Procedure for reductive methylation of protein to improve crystallizability. Nature Protocols DOI: 10.1038/nprot.2007.287


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