Margaret Su-chun Ho    Associate Professor, PI
InstituteSchool of Life Science and Technology
Research AreaGlia in neurodegenerative diseases

B.A. Department of Molecular and Cellular Biology, Biochemistry
1995 - 1998
 The University of California at Berkeley, CA 

Ph.D. Department of Molecular and Cellular Biology
1999 - 2003
 Harvard University, Cambridge, MA

Postdoctoral Fellow, Institute of Molecular Biology
2003 - 2010
 Academia Sinica, Taiwan

Professor, School of Medicine
2010 - 2017
 Tongji University, Shanghai

Associate Professor, PI, School of Life Science and Technology
 ShanghaiTech University, Shanghai

Research Interests
Glia are the most abundant cell types in the nervous system and participate in virtually all aspects of brain function. Dysfunction in glial cells causes serious and significant pathology that leads to multiple brain diseases. In addition to our previous and current work on glia and neuronal development, my research interest focuses on the following aspects pertaining glial function, including 1) glial-mediated mechanism underlying neurodegeneration, 2) glial lipid droplets-based formation in pathological condition, and 3) optogenetic studies on the role of glia in neuronal circuits.

Selected Publications
• Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS* Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease. Cell Rep. 2017 Jan 31;18(5):1132-1143.  

• Xiao X, Chen C, Yu TM, Ou J, Rui M, Zhai Y, He Y, Xue L, Ho MS* Molecular Chaperone Calnexin Regulates the Function of Drosophila Sodium Channel Paralytic. Front Mol Neurosci. 2017 Mar 7;10:57 

• Xi X, Lu L, Zhuge CC, Chen X, Zhai Y, Cheng J, Mao H, Yang CC, Tan BC, Lee YN, Chien CT, Ho MS* The hypoparathyroidism-associated mutation in Drosophila Gcm compromises protein stability and glial cell formation. Sci Rep. 2017 Jan 4;7:39856 

• Chen C, Yin S, Cao W, Ho MS* Drosophila ubiquitin E3 ligase dSmurf is required for synapse remodeling and axon pruning by glia. J Genet Genomics. 2017 Jan 20;44(1):67-70 

• Ho MS, Chen H, Chen M, Jacques C, Giangrande A, Chien CT Gcm protein degradation mediated by two F-box proteins suppresses proliferation of glial progenitors. Proc Natl Acad Sci U S A. 2009 106 (16):6778-83