Shuijin He    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaDevelopmental Neuroscience

Dr. Shuijin received a B.A. degree in Biochemistry in 2000 from Lanzhou University and obtained a M.S. degree in Biophysics in 2003 from University of Science and Technology of China. He earned a Ph.D degree in Neuroscience in 2010 from Uniformed Services University of the Health Sciences in Maryland, US. He completed his postdoc training in 2015 at Memorial Sloan-Kettering Cancer Center in New York, US. He joined School of Life Sciences and Technology at ShanghaiTech University as an assistant professor, PI since 2015.

Research Interests
The mammalian neocortex progressively develops in a precise chronological order. Our main research interest is to understand the development of different neural activities in the embryonic neocortex and their roles in the formation of highly specific neuronal circuits of the adult mammalian neocortex. Currently, we particularly focus on the role of gap junction (electrical synapse) in the developing neocortex and the molecular mechanisms for gap junction formation. In addition, we are also interested in exploring the possibility of the utility of endogenous adult neural stem cells in the hippocampal dentate gyrus for a treatment of the temporal lobe epilepsy. We investigate these unanswered questions using a combination of experimental approaches including multiple-electrode whole-cell recordings, optogenetics, molecular cell biology, and imaging.

Selected Publications

1.  He S, Li Z, Ge S, Yu Y-C, Shi S-H (2015) Inside-out radial glial migration facilitates lineage-dependent microcircuit assembly in the neocortex. Neuron 86(5): 1159-66.

2.   Xu H-T, Han Z, Gao P,He S, Li Z, Shi W, Kodish O, Shao W, Brown KN, Huang K and Shi S-H. (2014) Distinct lineage-dependent structural and functional organization of the hippocampus. Cell 157(7): 1552-64.

3.  He S, Bausch SB (2014) Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in anin vitromodel of limbic epileptogenesis. Neuropharmacology 77: 379-86.

4.  He S, Shao L-R, Wang Y and Bausch SB (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition. J Neurophysiol.109(6): 1535-47.

5.   Yu Y-C#*,He S#*, Chen S, Fu Y, Brown KN, Yao X-H, Ma J, Gao P, Sosinsky GE, Huang K and Shi S-H* (2012) Preferential electrical coupling regulates lineage-dependent microcircuit assembly in the neocortex. Nature 486(7401):113-7.

#, co-first; *, corresponding authors.

6.  He S, Shao L-R, Rittase WB and Bausch SB (2012) Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology 37(6): 1338-56.

7.   Bausch SB,He S, Petrova Y, Wang XM, McNamara JO (2006) Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. J Neurophysiol. 96(4):2151-67.