Ji Hu    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaCircuit Mechanism of Emotion
Contact Info.huji@@shanghaitech.edu.cn

Dr. Ji Hu obtained his bachelor degree from Huazhong University of Science and Technology in 2003, and was accepted into the Institute of Neuroscience, Chinese Academy of Sciences in the same year. In 2005 he transferred to the National Institute of Biological Sciences (NIBS)/Institute of Biophysics, CAS in Beijing. Dr. Hu received his Ph.D. degree in neurobiology in 2008. In 2009, he started his postdoctoral training in Picower Institute for learning and memory at MIT. Dr. Hu returned to China to work at Xi’an Jiaotong University in 2013 and then joined the School of Life Science and Technology of ShanghaiTech University as assistant professor (Tenure-track), PI since April of 2014. Dr.Hu was selected to the “Young 1000 talented scholar” in 2014.

Research Interests
We develop and apply cutting-edge methods, by combining optical imaging, neuromodulation, genetic labeling and circuit tracings to functional dissect the neural mechanisms of emotion and associated psychiatric diseases. The laboratory has internationally leading and comprehensive optical imaging instruments (two-photon microscope, gradient refraction lens, fiber photometric measurement) and technical means. We are using these new methods to attack several related neurobiological questions: 1. Stress neurobiology; 2. Circuit mechanisms of neuropsychopharmacology; 3. New strategies for the treatment of psychiatric disorders. Our research will contribute to the treatment of important mental illnesses such as depression and anxiety.

Selected Publications

Research Articles * Corresponding author

1. Shouhua Zhang; Fei Lv; Yuan Yuan; Chengyu Fan; Jiang Li; Wenzhi Sun; Ji Hu*, Whole-brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons, Frontiers in Neuroscience (2019)

2. Zheng-dong Zhao; Zongming Chen; Xinkuan Xiang; Mengna Hu; Hengchang Xie; Xiaoning Jia; Fang Cai; Yuting Cui; Zijun Chen; Lechen Qian; Jiashu Liu; Congping Shang; Yiqing Yang; Xinyan Ni; Wenzhi Sun; Ji Hu; Peng Cao; Haohong Li; Wei L Shen, Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting, Nature Neuroscience (2019)

3. Haibin Zhou; Shouhua Zhang; Fei Lv; Wenzhi Sun; Lihua Wang; Chunhai Fan; Jiang Li*; Ji Hu*, Citrateassisted efficient local delivery of naked oligonucleotide into live mouse brain cells, Cell Proliferation, 2019, e12622

4. Xin-Yu Su; Ming Chen; Yuan Yuan; Ying Li; Su-Shan Guo; Huo-Qing Luo; Huang Cheng; Wenzhi Sun; Yong Li; Michael X. Zhu; Ming-Gang Liu*Ji Hu*; Tian-Le Xu*, Central Processing of Itch in the Midbrain Reward Center, Neuron (2019)

5. Yuan Yuan; Wei Wu; Ming Chen; Fang Cai; Chengyu Fan; Wei Shen; Wenzhi Sun*Ji Hu*, Reward Inhibits Paraventricular CRH Neurons to Relieve Stress, Current Biology, 2019, 29: 1~9

6. Rongfeng Hu; Juen Zhang; Minmin Luo; Ji Hu*, Response Patterns of GABAergic Neurons in the Anterior Piriform Cortex of Awake Mice, Cerebral Cortex, 2017.6.1, 27(6): 3110~3124

7. Rongfeng Hu; Sen Jin; Xiaobin He; Fuqiang Xu; Ji Hu*, Whole-Brain Monosynaptic Afferent Inputs to Basal Forebrain Cholinergic System, Frontiers in Neuroanatomy, 2016.10.10, 10: 0~98

8. Andrii Rudenko; Jinsoo Seo; Ji Hu; Susan C Su; Froylan Calderon de Anda; Omer Durak; Maria Ericsson; Marie Carlén; Li-Huei Tsai, Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment, Journal of Neuroscience (2015)

9. Tao Chen, Kohei Koga, Giannina Descalzi, Shuang Qiu, Jian Wang, Le-Shi Zhang, Zhi-Jian Zhang, Xiao-Bin He, Xin Qin, Fu-Qiang Xu, Ji Hu, Feng Wei, Richard L Huganir, Yun-Qing Li; Min Zhuo,Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury, Molecular Pain, 2014, 10:33

10. Rong Gong#; Cheng Ding#; Ji Hu#; Yao Lu; Fei Liu; Elizabeth Mann; Fuqiang Xu,; Mitchell B. Cohen; Minmin Luo, Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior, Science, 2011.9.16, 333(6049): 1642~1646 (#co-first author)

11. Lili Gao; Ji Hu; Chun Zhong; Minmin Luo, Integration of CO2 and odorant signals in the mouse olfactory bulb, Neuroscience, 2011, 3(27):881-892

12. Ji Hu#; Chun Zhong#; Cheng Ding; Qiuyi Chi; Andreas Walz; Peter Mombaerts; Hiroaki Matsunami; Minmin Luo(*), Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse, Science, 2007.8.17, 317(5840): 953~957(#co-first author)

13. Liming Sun; Huayi Wang; Ji Hu; Jinlong Han; Hiroaki Matsunami; Minmin Luo, Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate, Proceedings of the National Academy of Sciences of the United States of America, 2009.2.10, 106(6): 2041~2046


Review article*Corresponding author

14. Fang Luo; Yin Wei; Ziyue Wang; Minmin Luo; Ji Hu*, Genetically encoded neural activity indicators, Brain Science Advances, (2018)

15. Yan Yang; Hao Wang; Ji Hu*; Hailan Hu*, Lateral habenula in the pathophysiology of depression, Current Opinion in Neurobiology, 2018.02, 48: 90~96, (*co-corresponding author)

16. Minmin Luo; Liming Sun; Ji HuNeural detection of gases--carbon dioxide, oxygen--in vertebrates and invertebratesCurrent Opinion in Neurobiology, 2009.8, 19(4): 354~361