Chao-Po Lin    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaStem cell biology; RNA biology

1994.9-1998.6B.S. in the Department of Zoology, National Taiwan University
2000.9-2002.6M.S. in the Institute of Genetics, National Yang-Ming University
2002.9-2003.8Research assistant, Institute of Microbiology, National Taiwan University College of Medicine
2003.9-2010.1Ph.D. in the Department of Pharmacology, Rutgers University, USA
2010.4-2017.3Postdoctoral fellow, University of California at Berkeley, USA
2007.6-now Assistant Professor, PI, ShanghaiTech Uninversity, China

Research Interests
Our group is interested in the function(s) of microRNAs in pluripotent stem cells, as well as the function(s) of retrotransposons in mammalian development. First, we explore the importance of the p53-microRNA axis in somatic reprogramming, or the generation of induced pluripotent stem cells (iPSCs). Second, we study the roles of microRNAs in modulating the totipotent-like cell fate potential in pluripotent stem cells, a novel potency state of pluripotent stem cells we identified recently (Science, 2017). Finally, we investigate the functional roles of retrotransposons during mammalian pre-implantation and post-implantation development.

Selected Publications
1. Lin CP and He L. (2017) Noncoding RNAs in Cancer Development. Annual Reviews of Cancer Biology. 1:163-84.

2.Choi YJ*, Lin CP*#, Risso D*, Chen S, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Kim SY, Speed TP, and He L#. (2017) Deficiency of miR-34a expands cell fate potential in pluripotent stem cells. Science. 10;355(6325) (* equal contribution; # corresponding author)

3.Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, and He L. (2013) A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 28(5): 438-50

4. Lin CP, Choi YJ, Hicks GG, and He L. (2011) The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle. 11:2063-72

5.Choi YJ*, Lin CP*, Ho J, Zhong Y, He X, Okada N, Bu P, Zhong Y, Kim SY, Bennett MJ, Chen C, Ozturk A, Hicks G, Hannon GJ and He L. (2010) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 13:1353-60 (* equal contribution)

6. Lin CP*, Ban Y*, Lyu YL, and Liu LF. (2009) Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double-strand breaks at arrested replication forks. J Biol Chem. 284: 28084-92 (* equal contribution)

7.Tsai YC, Qi H, Lin CP, Lin RK, Kerrigan J, Rzuczek SG, LaVoie EJ, Rice JE, Pilch DS, and Liu LF (2009) A G-Quadruplex stabilizer induces M phase cell cycle arrest. J Biol Chem. 284: 22535-43

8. Lin CP, Ban Y, Lyu YL, Desai SD, and Liu LF. (2008) A Ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes. J Biol Chem. 283: 21074-83

9.Lyu YL, Kerrigan JE, Lin CP, Azarova AM, Tsai YC, Ban Y, and Liu LF. (2007) Topoisomerase II mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res. 67: 8839-46

10.Azarova AM*, Lyu YL*, Lin CP, Tsai YC, Lau JY, Wang JC, and Liu LF. (2007) Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A. 104: 11014-9 (* equal contribution)

11.Zhang A*, Lyu YL*, Lin CP, Zhou N, Azarova AM, Wood LM, and Liu LF. (2006) A protease pathway for the repair of topoisomerase II-DNA covalent complexes. J Biol Chem. 281: 35997-6003

12.Qi H, Lin CP, Fu X, Wood LM, Liu AA, Tsai YC, Chen Y, Barbieri CM, Pilch DS, and Liu LF. (2006) G-quadruplexes induce apoptosis in tumor cells. Cancer Res. 66: 11808-16