Yanfen Liu    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaProtein Quality Control and Neurodegenerative Diseases
Contact Info.liuyf@@shanghaitech.edu.cn

Dr. Yanfen Liu received a B.A. degree in  Biology in 2002 from Zhejiang University, and obtained her Ph.D. degree in  Biochemistry and Molecular Biology in 2008 from Peking Union Medical  College/NIBS. She was a Postdoctoral Fellow between 2009 and 2014 at the  National Institutes of Health (NIH)/NIDDK in the United States. Dr. Liu joined  School of Life Sciences and Technology at ShanghaiTech University as an  assistant professor, PI since 2015.

Research  Interests
We are interested in understanding how  eukaryotic cells deal with protein misfolding. Removal of unwanted proteins by  Ubiquitin-Proteasome System (UPS) is an integral component of the cellular  quality control program that offers an essential protective mechanism to  maintain protein homeostasis. Impairment in protein quality control results in  protein aggregates associated with various diseases from neurodegenerative  disorders to cancers. In short term, we want to study how the  ubiquitin-proteasome system (UPS) and autophagy is regulated to maintain protein  and organelle homeostasis with an emphasis on ubiquitin ligases (E3s) and  deubiquitinating enzymes (DUBs). In long term, we wish to elucidate the  functional interplays between UPS and other degradation pathways such as  autophagy in human development and diseases.

Selected  Publications

1. Cong Yan, Huanhuan Huo, Cuiwei Yang, Tao  Zhang, Yuanyuan Chu, and Yanfen Liu (2018). Ubiquitin C-Terminal  Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through  its deubiquitinating enzyme activity. Biochemical and Biophysical Research  Communications, 497(2):726-733.

2. Yupeng Zhao, Ting Zhang, Huanhuan Huo,  Yihong Ye, and Yanfen Liu (2016). Lunapark Is a Component of a Ubiquitin  Ligase Complex Localized to the Endoplasmic Reticulum Three-way  Junctions. The Journal of Biological Chemistry, 291(35):  18252-62. 

3. Ting Zhang, Yue Xu, Yanfen Liu, and  Yihong Ye (2015). gp78 functions downstream of Hrd1 to promote degradation of  misfolded proteins of the endoplasmic reticulum. Molecular Biology of the  Cell. 26(24): 4438–4450.

4. Yanfen Liu, Nia Soetandyo, Jin-gu  Lee, Liping Liu, Yue Xu, William M Clemons and Yihong Ye (2014). USP13  antagonizes gp78 to maintain functionality of a chaperone in ER-associated  degradation. eLIFE, 3:e01369. doi: 10.7554/eLife.01369. (Commented in  Nature Cell Biology)

5. Yue Xu, Yanfen Liu, Jin-gu Lee,  Yihong Ye (2013). A ubiquitin-like domain recruits an oligomeric chaperone to a  retrotranslocation complex in endoplasmic reticulum-associated  degradation. The Journal of Biological Chemistry,  288(25):18068-76.

6. Yanfen Liu and Yihong Ye (2012).  The roles of p97-associated deubiquitinases in protein quality control at the  endoplasmic reticulum. Current Protein and Peptide Science, 13(5):  436-446.

7. Wang, Qiuyan*, Liu, Yanfen*,  Soetandyo, Nia, Baek, Kheewoong, Hegde, Ramanujan, Ye, Yihong (2011). A  chaperone holdase maintains polypeptides in soluble states for proteasome  degradation. Molecular Cell, 42(6):758-70 (* co-first authorship)  

8. Yanfen Liu and Yihong Ye (2011)  Proteostasis in the Endoplasmic reticulum: a new site of perturbation for  targeted cancer therapy. Cell Research, 21, 867-883.

9. Yanfen Liu, Feng Wang, Huiyong  Zhang, Hang He, Ligeng Ma and Xing Wang Deng (2008). Functional Characterization  of Arabidopsis Ubiquitin-specific Protease Gene Family Revealed Specific Role  and Redundancy of Individual Members in Development. Plant Journal, 55,  844-856.