Yong Cang    Associate Professor, PI
InstituteSchool of Life Science and Technology
Research AreaGenetics of Cancer Immunity; Protein Ubiquitination
Contact Info.cangyong@@shanghaitech.edu.cn

1988-1992: Fudan  University, BS in Biochemistry
1996-2001: Albert Einstein College of  Medicine, PhD in Molecular Genetics

2001-2007:  Columbia University Medical Center/HHMI, Postdoc
2007-2010: Sanford-Burnham  Medical Research Institute, Assistant Professor in Signal Transduction  Program
2010-2017: Zhejiang University Life Science Institute,  Professor
2017/11-present: ShanghaiTech University School of Life Science and  Technology, Associate Professor, Principal Investigator  

Research  Interests
We have been studying the role of protein  ubiquitination in development and diseases using cell biology and mouse genetic  tools, and investigating how small molecule compounds hijack E3 ubiquitin  ligases to control cancer cell proliferation and modulate immune cell  activation. More recently we have are employing the customized CRISPR-Cas9  library screen in cultured cells and in xenografts to understand how cancer  cells escape immune elimination.

Selected  Publications

1. Hou,  L., Zhao, J., Gao, S., Ji, T., Song, T., Li, Y., Wang, J., Geng, C., Long, M.,  Chen, J., Lin, H., Cai, X., and Cang, Y.* (2019) Restriction of  hepatitis B virus replication by c-Abl–induced proteasomal degradation of the  viral polymerase. Science Advances 5, eaau7130  


2. Liu, J., Song, T., Zhou, W., Xing,  L.J., Ho, M., Peng, Z., Tai,Y.T., Hideshima, T.,  Anderson, K.C., and  Cang, Y. * (2019)  A genome-scale CRISPR-Cas9 screening in myeloma  cells identifies regulators of immunomodulatory drug  sensitivity. Leukemia 33(1):171-180. Epub 2018 Jul 19.


3. Song, T., Liang, S., Liu,, J.,  Zhang, T., Yin, Y., Geng, C., Gao, S., Feng, Y., Xu, H., Guo, D., Roberts, A.,  Gu, Y., and Cang, Y.* (2018) CRL4  antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate  learning and memory. PLoS  Genet.  14(1):e1007165


4. Li, G.F., Ji, T., Chen, J., Fu,  Y.F., Hou, L.D., Feng, Y., Song, T.Y., Zhao, J., Endo, Y., Lin, H., Cai, X.J.,  and and Cang, Y.* (2017) CRL4(DCAF8)  ubiquitin ligase targets histone H3K79 and promotes H3K9 methylation in the  liver. Cell  Reports, 18(6):1499-1511


5.  Gao, S.B., Geng, C.L, Song, T.Y.,  Liu, J.Y., Feng, Y., and Cang, Y.* (2017)  Activation of c-Abl kinase potentiates the anti-myeloma drug lenalidomide by  promoting DDA1 recruitment to the CRL4 ubiquitin ligase. JBC,  292(9):3683-3691


6.  Jin, S.F., Chen, L., Chen, J.,  Histen, G., Lin, Z.Z., Gross, S., Hixon, J., Chen, Y., Kung, C., Chen, Y.W., Fu,  Y.F., Lu, Y.X., Lin, H., Cai, X.J., Yang, H., Dorsch, M., Su, M., Biller, S., Cang, Y.* (2015) ALDH2(E487K) mutation  increases protein turnover and promotes murine hepatocarcinogenesis. PNAS 112:  9088-93 


7.  Liu, J.Y., Ye, J., Zou, X.L., Xu,  Z.H., Yan, F., Zou, X.X., Chen, Z., Li, Y.Z., and Cang, Y.* (2014) CRL4CRBN E3 ubiquitin ligase  restricts BK channel activity and prevents epileptogenesis. Nature  Communications 5: 3924 


8.  Yamaji, S., Zhang, M., Zhang, J.,  Yoko, E., Bibikova, E., Goff, S.P., and Cang,  Y. * (2010) Hepatocyte-specific deletion of DDB1 induces liver regeneration  and tumorigenesis. PNAS, 107(51):22237-42