|1997-2001, B.S. Biochemistry, Department of Biochemistry, Nanjing University, Nanjing, China|
2011-2006, Ph.D. Neuroscience, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China
2006-2010, Postdoctoral fellow, MIT, Cambridge, Massachusetts, USA
2011-2017, Associate Professor, School of Life Science, Tsinghua University, Beijing, China
2017-now, Associate professor, PI, School of Life Science and Technology, ShanghaiTech University, Shanghai, China
|The lab has been focusing on exploring the circuitry and molecular mechanisms underlying memory formation and retrieval. We developed an in vivo imaging tool and data analysis system to directly measure the memory-related cortical responses in large scale. Combined with optogenetic and chemogenetic tools, we identified the memory trace neurons in layer 2 cortex and hippocampal dentate gyrus area and studied their dynamic activity of memory traces, underlying the long-term memory. Furthermore, a mechanism of epigenetic regulation was discovered within memory trace neurons to modulate the memory stability.|
1.Guangyu Wang*, Lun Wang*, Hong Xie*, Wenhan Luo, Yixiang Wang, Jun Jiang, Chun Xiao, Feng Xing, Ji-Song Guan#（2019）Switching from fear to no fear by different neural ensembles in mouse retrosplenial cortex.Cerebral Cortex Mar 19. pii: bhz050. doi: 10.1093/cercor/bhz050
2.Jun Jiang, Guangyu Wang, Wenhan Luo, Hong Xie, Ji-Song Guan#. (2018) Mammillary body regulates state-dependent fear by alternating cortical oscillations. Sci Rep. 6: 26597. Sep 7;8(1):13471. doi: 10.1038/s41598-018-31622-z
3.Ruxing Fu, Wenhan Luo, Roy Nazempour, Daxin Tan, He Ding, Kaiyuan Zhang, Lan Yin,Ji-Song Guan#, Xin Sheng#, (2018) Implantable and Biodegradable Poly (L-lactic acid) Fibers for Optical Neural Interfaces, Advanced Optical Materials, Feb, 3(6):1700941 10.1002/
4.Xinlu Ding, SanXiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie& Ji-Song Guan#(2017) Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation. Nat Neurosci. May;20(5):690-699, doi:10.1038/nn.4536
5.Guan JS#, Jiang J, Xie H and Liu K-Y. (2016) How does the sparse memory Engram: Neurons encode the memory of a spatial-temporal event?Front. Neural Circuits 10: 61. (Review)
6.Zhu Τ, Liang C, Li D, Tian M, Liu S, Gao G and Guan JS#. (2016) Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep. 6: 26597.
7.Guan JS#, Xie H, Ding XL. (2015) The role of epigenetic regulation in learning and memory. Exp Neuro.268: 30-36.(Review)
8.Xie H, Liu Y, Zhu YZ, Ding XL, Yang YH and Guan JS#. (2014) In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A.111: 2788-2793.
9.Liu P, Zhu T, Liang C, Bai B, Gao GJ and Guan JS#. (2014) A one-step screening system for multi-zinc finger proteins targeting a long-DNA sequence. SCIENTIA SINICA Vitae 44: 1061–1072
10.Guan JS*, Haggarty SJ*, Giacometti E*, Dannenberg JH*, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang XY, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R and Tsai LH. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity.Nature459: 55-60.
11.Guan JS*, Xu ZZ*, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L and Zhang X (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell 122: 619-631.