Guanjun Gao    Associate Professor, PI
InstituteSchool of Life Science and Technology
Research AreaChromatin and Epigenetics, Gene Editing

Dr. Guanjun Gao graduated from Department of Agronomy of Yangzhou University in Jiangsu in 1996, and received a PhD degree from Zhejiang University in 2005. He did the postdoctoral research at Lab of Biochemistry and Molecular Biology (LBMB) in National Cancer Institute of NIH, USA from 2006-2010. From 2010~2011, he worked as Research Fellow at LBMB lab in NIH. From 2011, he became a PI at School of Life Sciences in Tsinghua University. In middle of 2017, he moved to Shanghai and became an associate professor at School of Life Science and Technology in ShanghaiTech University.

Research Interests
The major mission of Gao-lab is to use Drosophila and mammalian cell systems to achieve a comprehensive understanding of the mechanisms of chromatin and (epi-)genetic factors, particularly with a focus on long non-coding RNAs and histone epigenetic codes in development, reproduction, innate immunology, aging and cancer disease. Towards achieving this mission, Gao-lab bridges the new genetic methods and biochemistry approaches into investigation of the mechanisms of those (epi-)genetics factors involved in fundamental biological processes. Their research will define not only epigenetic molecules and pathways but also many fundamental biological processes that impact human health.

Selected Publications
1.Zhang W#, Zhang X#, Xue Z#, Li Y#, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J*, Gao G*. Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev Cell. 2019 Feb 11;48(3):406-419.

2.Xiao X#, Yang L#, Pang X#, Zhang R, Zhu Y, Wang P, Gao G* & Cheng G*. A Mesh-Duox pathway regulates homeostasis in the insect gut. Nature Microbiology. 2017 Mar 1;2:17020. (Co-corresponding author)

3.Wen K#, Yang L#, Xiong T#, Di C ,Ma D, Wu M, Xue Z, Zhang X, Long L, Zhang J, Bi X, Dai J, Zhang Ren M, Long L, Zhang Q, Lu ZJ.& Gao G*. Critical roles of long noncoding RNAs in Drosophila spermatogenesis. Genome Research. 2016 Sep;2. (F1000 recommendation)

4.Zhu Τ, Liang C, Li D, Tian M, Liu S, Gao G, Guan JS. Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep. 2016 May 27;6:26597. 

5.Hu L, Xu J, Yin MX, Zhang L, Lu Y, Wu W, Xue Z, Ho MS, Gao G, Zhao Y, Zhang L*. Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. Cell Discov. 2016 Feb 23;2:15047. 

6.Gerstein MB, Rozowsky, Yan KK… Gao G… Waterston R*. Comparative analysis of the transcriptome across distant species. Nature. 2014 Aug 28; 512(7515):445-448.

7.Xue Z, Wu M, Wen K, Ren M, Long L, Zhang X. & Gao G*. CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila. G3:Genes|Genomics| Genetics. 2014 Sep 5. pii: g3.114.014159. (2014 highlight in GSA)

8.Xue Z, Ren M, Wu M, Dai J, Rong YS. & Gao G*. Efficient gene knock-out and knock-in with transgenic Cas9 in Drosophila. G3:Genes|Genomics| Genetics. 2014 Mar 21; 4(5):925-9. (2014 highlight in GSA)

9.Wei W, Xin H, Roy B, Dai J, Miao Y* & Gao G*. Heritable genome editing with CRISPR/Cas9 in the silkworm, Bombyx mori. PLoS ONE. 2014 Jul 11; 9(7):e101210.

10.Yu Z#, Ren M#, Wang Z, Zhang B, Rong YS, Jiao R* & Gao G*. Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics. 2013 Sep; 195(1):289-91. (2013 highlight in GSA,citation>200)

11.Wei C, Liu J, Yu Z, Zhang B*, Gao G*, Jiao R*. TALEN or Cas9 - rapid, efficient and specific choices for genome modifications. J Genet Genomics. 2013 Jun 20;40(6):281-9. (Co-corresponding author)

12. Gao, G. J., Chen, Y., Wesolowska, N. & Rong, YK*. A paternal imprint for the inheritance of telomere identity in Drosophila. PNAS. 2011 Mar 22; 108(12):4932-7.

13. Gao, G. J.,Walse J., Michelle, B., Patrizia, M., Natalia, W., Chen, J. & Rong, YK*. HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J. 2010, Feb 17; 29(4):819-29.

14. Gao, G. J#., Bi, X#., Chen, J., Srikanta, D. & Rong, YK*. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. PNAS. 2009, Jun 30; 106(26):10728-33.

15. Gao, G. J., Conor, M., Chen, J. & Rong, YK*. A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila. PNAS. 2008, Sep 16; 105(37):13999-4004.