Lei Li    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaSynapse formation
Contact Info.lilei@@shanghaitech.edu.cn

Dr. Li graduated from Nanjing University in 2007 with a Bachelor’s degree in Biotechnology and received his Ph. D. in cell biology from Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2013. After graduation, he joined Dr. Lin Mei’s lab in Medical School of Georgia, Augusta University as a Postdoctoral Fellow. In Jan. 2018, he joined School of Life Science and Technology at ShanghaiTech University as an Assistant Professor (Tenure-track), PI.

Research Interests
Synapses are fundamental units of neural circuitry that enable communications between neurons and between a neuron and its target cell. Synaptic transmission and plasticity are critical for brain functions, including sensation, cognition, memory, and motor control. The long-term goal of our lab is to understand molecular mechanisms of synapse formation and maintenance. Currently, we are interested in 1) understanding the molecular mechanisms of neuromuscular junction (NMJ) formation during development; 2) investigating the mechanisms underlying NMJ decline in aging and neurological disorders. Our studies may contribute to new diagnostic and therapeutic strategies for these neurological disorders.

Selected Publications
1. Lei Li, Wen-Cheng Xiong and Lin Mei (2018). Neuromuscular junction formation, aging and disorders.Annual Review of Physiology., 80: (1).

2. Lei Li*, Yu Cao*, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chengyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong and Lin Mei (2016). Enzymatic activity of the scaffold protein Rapsyn for synapse formation. Neuron, 92: 1007-1019. (*, equal contribution)

3.Xiang-Dong Sun*#, Lei Li*, Fang Liu, Zhi-Hui Huang, Jonathan. C. Bean, Hui-Feng Jiao, Arnab Barik, Seon-Myung Kim, Haitao Wu, Chengyong Shen, Yun Tian, Thiri W. Lin, Ryan Bates, Anupama Sathyamurthy, Yong-Jun Chen, Dong-Min Yin, Lei Xiong, Hui-Ping Lin, Jin-Xia Hu, Bao-Ming Li, Tian-Ming Gao, Wen-Cheng Xiong and Lin Mei# (2016). Lrp4 in astrocytes modulates glutamatergic transmission.Nat. Neurosci., 19: 1010-1018. (*: equal contribution; #, co-correspondence)

4.Arnab Barik*, Lei Li*, Anupama Sathyamurthy, Wen-Cheng Xiong and Lin Mei (2016). Schwann cells in neuromuscular junction formation and maintenance. J. Neurosci., 36: 9770-9781. (*, equal contribution)

5. Lei Li, Dan Wei, Qiong Wang, Jing Pan, Rong Liu, Xu Zhang and Lan Bao (2012). MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.

6.Haitao Wu*, Arnab Barik*, Yisheng Lu, Chengyong Shen, Andrew Bowman, Lei Li, Anupama Sathyamurthy, Thiri Lin, Wen-Cheng Xiong and Lin Mei (2015). Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. eLife, 4: e07266. (*, equal contribution)

7.Arnab Barik*, Yisheng Lu*, A. Sathyamurthy, Andrew Bowman, Chengyong Shen, Lei Li, Wen-Cheng Xiong and Lin Mei (2014). LRP4 is critical for neuromuscular junction maintenance. J. Neurosci., 34: 13892-13905. (*, equal contribution)

8.Huifeng Jiao*, Xiang-Dong Sun*, Ryan Bates*, Lei Xiong, Fang Liu, Lei Li, Shunqi Wang, Mingtao Xiong, Bao-Ming Li, Wen-Cheng Xiong and Lin Mei (2017). Tmem108 is required for glutamatergic transmission in dentate gyrus. PNAS, 114: 1177-1182.

9.Wenjing Li, Chen Zhong, Lei Li, Bingfa Sun, Weiyi Wang, Shutong Xu, Tianlong Zhang, Chungang Wang, Lan Bao and Jianping Ding (2012). Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin. Cell Res., 22: 1707-711.

10.Yuan-Yuan Su, Mingyu Ye, Lei Li, Chao Liu, Jing Pan, Wen-Wen Liu, Xing-Yu Jiang, Xu Zhang, Yousheng Shu and Lan Bao (2013). KIF5B promotes the forward transport and axonal function of voltage-gated sodium channel Nav1.8. J Neurosci., 33: 17884-896.