Zhen-Ge Luo    Vice Dean, Professor
InstituteSchool of Life Science and Technology
Research AreaNeural Development and Regeneration
Contact Info.luozhg@@shanghaitech.edu.cn


Biography
Dr. Luo received his BS degree from Nankai  University, Tianjin in 1988 and his Ph. D. degree from Academy of Military  Medical Sciences (AMMS), Beijing in 1995. He was appointed as associate  investigator at AMMS in 1998 and received post-doctoral training in the  department of neurobiology, University of Alabama at Birmingham (UAB), USA from  January 2000 to May 2003. He worked in the Institute of Neuroscience (ION),  Chinese Academy of Sciences (CAS), as a Principal Investigator from 2003-2018.  He joined the School of Life Science and Technology (SLST) at ShanghaiTech  University as a tenured Full Professor since September  2018.

Research  Interests
We aim to decipher molecular and cellular  mechanisms underlying neural development and brain wiring. We are also  interested in developing novel strategies to promote neuronal regeneration after  injury. Major topics include: cortex development and evolution; nerve growth and  guidance; synapse formation and pruning; neuronal injury and  repair.

Selected  Publications

1. Ou, M.Y., Ju, X.C., Cai, Y.J., Sun, X.Y., Wang, J.F., Fu, X.Q., Sun, Q., Luo, Z.G. * (2020) Heterogeneous nuclear ribonucleoprotein A3a controls mitotic progression of neural progenitors via interaction with cohesin. Development. .

2. Fu, X.Q., Peng, J., Wang, A.H., Luo, Z.G.*(2020) Tumor necrosis factor alpha mediates neuromuscular synapse elimination. Cell Discovery6:9. DOI https://doi.org/10.1038/s41421-020-0143-5.

3.  Peng, J.Sheng, A.L.Xiao, Q.Shen, L.Ju, X.C.Zhang, M.He, S.T.Wu, C.Luo, Z.G.* (2019) Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum. J Mol Cell Biol. 11(8):636-648.

4.   He, M., Ding, Y.T., Chu, C., Tang, J., Xiao, Q. and Luo, Z.G.* (2016) Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury. Proc. Natl. Acad. Sci. USA. 113(40):11324-11329.

5.   Ju, X.C., Hou, Q.Q., Sheng, A.L., Wu, K.Y., Zhou, Y., Jin, Y., Wen, T.Q., Yang, Z.G., Wang, X.Q., Luo, Z.G.* (2016) The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. eLifeAug 9;5. pii: e18197. doi: 10.7554/eLife.18197.

6.  Wu, K.Y., Zuo, G. L., Li, X.F., Ye, Q., Deng, Y.Q., Huang, X. Y., Wu-Chun Cao, Qin, C. F., Luo, Z.G.* (2016) Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice.Cell Res. 26:645-654. (Cover story, Highlighted, 2016 Sanofi-Cell Research Outstanding Paper Award).

7.  Wu, K.Y., He, M., Hou, Q.Q., Sheng, A.L., Yuan, L., Liu, Y., Liu, W.W., Li, G., Jiang, X.Y., Luo, Z.G.*(2014) Semaphorin-3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and callosal axon projection. Sci. Signal. 7, ra81.

8.  Xu, X.H., Deng, C.Y., Liu Y., He, M., Peng, J., Wang, T., Yuan, L., Zheng, Z.S., Blackshear, P.J & Luo, Z.G.* (2014) MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development. Cell Res. 24: 576–594.

9.  Wang, J.Y., Chen, F., Fu, X.Q., Ding, C.S., Zhou, L., Zhang, X.H. & Luo, Z.G.* (2014) Caspase-3 cleavage of disheveled induces elimination of postsynaptic structures. Dev. Cell  28:670–684 (Highlighted by Preview in Developmental Cell 28, 604-606).

10. Deng, C.Y., Lei, W.L., Xu, X.H., Ju, X.C., Liu, Y. & Luo, Z.G.* (2014) Jip1 mediates anterograde transport of Rab10 cargos during neuronal polarization. J. Neurosci. 34:1710-1723.

11. Liu, Y., Xu, X.H., Chen, Q., Wang, T., Deng, C.Y., Song, B.L., Du, J.L., Luo, Z.G.*(2013) Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nat. Commun.4:2005 doi: 10.1038/ncomms3005.

12. Lei, W.L., Xing, S.G., Deng, C.Y., Ju, X.C., Jiang, X.Y., Luo, Z.G.* (2012) Laminin/beta1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization.Cell Res.22:954-972.

13. Wang, T., Liu, Y., Xu, X.H., Deng, C.Y., Wu, K.Y., Zhu, J., Fu, X.Q., He,M., and Luo, Z.G.*(2011) Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization.Dev. Cell.21:431-444. (Cover story and highlighted by “Faculty of 1000  Biology”).

14. Yang, G.Y., Liang, B., Zhu, J., and Luo, Z.G.*(2011) Calpain activation by wingless-type MMTV integration site family, member 5A (Wnt5a) promotes axonal growth.J. Biol. Chem. 286: 6566-6576. (Highlighted by “Faculty of 1000 Biology”).

15. Wang, J., Fu, X.Q., Lei, W.L., Wang, T., Sheng, A.L., Luo, Z.G.* (2010) Nuclear Factor Kappa B Controls AChR Clustering by Regulating Rapsyn Expression at the Neuromuscular Junction.J. Neurosci.30: 11104-11113.

16. Liang, B., Duan, B.Y., Zhou, X.P., Gong, J.X., Luo, Z.G.* (2010) Calpain activation promotes bace1 expression, APP processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.J Biol Chem285: 27737-27744.

17. Zhou, X.P., Wu, K.Y., Liang, B., Fu, X.Q., Luo, Z.G.*(2008) TrkB-mediated Activation of Geranylgeranyltransferase I Promotes Dendritic Morphogenesis. Proc. Natl. Acad. Sci. USA105: 17181-17186.

18. Wang, J., Ruan, N.J., Qian, L., Chen, F., Luo, Z.G.*(2008) Wnt/β-catenin signaling suppresses rapsyn expression and inhibits AChR clustering at the neuromuscular junction. J. Biol. Chem. 283: 21668-21675.

19. Zhang, X., Zhu, J., Yang, G.Y., Wang, Q.J., Qian, L., Chen, Y.M., Chen, F., Tao, Y., Hu, H.S., Wang, T., andLuo, Z.G.*(2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat. Cell Biol.9, 743-754. (Highlighted by News and Views in the same issue of Nat. Cell Biol., “Faculty of 1000 Biology”, and Nature China).

20. Chen, F., Qian, L., Yang, Z.H., Huang, Y., Ngo, S.T., Ruan, N.J., Wang, J., Schneider, C., Noakes, P.G., Ding, Y.Q., Mei, L., and Luo, Z.G.(2007) Rapsyn interaction with Calpain stabilizes AChR clusters at the neuromuscular junction. Neuron55: 247-260. (Highlighted by “Faculty of 1000 Biology”).

21. Chen, Y.M., Wang, Q.J., Hu, H.S.,Yu, P.C., Zhu, J., Drewes, G., Piwnica-Worms, H., Luo, Z.G.* (2006) Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/aPKC complex in regulating hippocampal neuronal polarity.Proc. Natl. Acad. Sci. USA103: 8534-8539.



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