Tiffany Horng    Associate Professor, PI
InstituteSchool of Life Science and Technology
Research AreaMacrophage Metabolism, Function, and Biology
Contact Info.tsyhorng

1995-1999 UC Berkeley, B.A., Molecular and Cellular Biology
1999-2003 Yale University, Ph.D., Immunology
2003-2007 Postdoctoral Fellow, Lab of Dr. Ruslan Medzhitov, Yale University
2007-2008 Postdoctoral Fellow, Lab of Dr. Anjana Rao, Immune Disease Institute, Harvard Medical School
2008-2014 Assistant Professor, Harvard T.H. Chan School of Public Health
2015-2018 Associate Professor, Harvard T.H. Chan School of Public Health
2018-present Associate Professor, School of Life Sciences and Technology, ShanghaiTech University

Research Interests
Macrophages are fascinating cells that control diverse biological and physiological processes. Our research focuses on how cellular metabolism regulates macrophage functions, including the interplay between metabolic processes and the signal transduction pathways that regulate macrophage activation, and mitochondrial metabolism and its influence on chromatin. We aim to elucidate the mechanisms by which cellular metabolism regulates macrophage functions in diverse contexts, of relevance to the many physiological and pathophysiological contexts in which macrophages play a role.

Selected Publications


Original Publications

1.Hargreaves DC, Horng T*, Medzhitov R*. Control of inducible gene expression by signal-dependent transcriptional elongation. *co-corresponding authors.Cell. Jul. 10, 2009. PMID: 19596240

2. Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer A, and Horng T.A critical role for calcium mobilization in activation of the NLRP3 inflammasome. PNAS. Jul. 10, 2012.PMID: 22733741

3.Byles V*, Covarrubias AJ*, Ben-Sahra I, Lamming D, Sabatini D, Manning B and Horng T.The TSC-mTOR pathway regulates macrophage polarization. *co-first authorship.Nature Communications. Nov. 27, 2013. PMID: 24280772

4.Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM and Horng T.Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. PNAS. Oct. 28, 2014.PMID: 25313054

5. Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Stapornkul TP, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, and Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. eLIFE. Feb. 19, 2016. PMID: 26894960

Commentary by Torres A et al. Immunometabolism: Metabolism fine-tunes macrophage activation. eLIFE. Feb 19, 2016. PMID: 26894957

6.Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki, Suzuki T, Yamamoto M, Horng T, and Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Science Reports. Aug 18;7(1):8801. PMID: 28821730

7.Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, and Blander JM. Innate sensing of microbial viability orchestrates stress-mediated autophagy of the endoplasmic reticulum. Cell. Nov 2;171(4):809-823. PMID: 29056340

8.P. Kent Langston1, Aya Nambu1, Jonathan Jung1,2, Munehiko Shibata1, H. Ibrahim Aksoylar1, Jiahui Lei1, Peining Xu3, Mary T. Doan3, Helen Jiang3, Michael R. MacArthur1, Xia Gao4, Yong Kong5, Edward T. Chouchani6, Jason W. Locasale4, Nathaniel W. Synder3, and Tiffany Horng1,7* Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature Immunology. In press.

Reviews and Commentaries

1.Medzhitov R and Horng T*.Transcriptional control of the inflammatory response. *co-corresponding authors.Nature Reviews Immunology. Oct. 2009. PMID: 19859064

2.Horng T and Hotamisligil.Linking the inflammasome to obesity-related disease.Nature Medicine. Feb. 2011. PMID: 21297609

3.Covarrubias A, Byles V, and Horng T.ROS sets the stage for macrophage differentiation.Cell Research. Aug. 2013.PMID: 23835480

4.Kagan JC and Horng T.NLRP3 inflammasome activation:CD36 serves double duty.Nature Immunology. Aug. 2013. PMID: 23867926

5.Horng, T.Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome.Trends in Immunology. Jun. 2014. PMID: 24646829

6.Covarrubias AJ and Horng T.IL-6 strikes a balance during metabolic inflammation. Cell Metabolism, Jun. 2014. PMID: 24896536

7.Horng, T.mTOR trains heightened macrophage responses. Trends in Immunology. Jan. 2015. PMID: 25488670

8.Covarrubias AJ, Aksoylar HI and Horng T.Control of macrophage metabolism and activation by mTOR and Akt signaling.Seminars in Immunology. Aug. 2015.

9.Langston PK, Shibata M and Horng T.Metabolism supports macrophage activation.Frontiers in Immunology. Jan. 2017. PMID: 28197151.

10.Olivas J and Horng T.Sugar fuels T cell memory. Nature Cell Biology. Jan. 2018. PMID29269950.

11.Jung J, Zeng H, and Horng T. Metabolism as a guiding force for immunity. Nature Cell Biology. In press.

12.Yan J, Wang R and Horng T. mTOR is Key to T cell Transdifferentiation. Cell Metabolism. Feb. 2019. PMID: 30726756.