James E. Rothman    Distinguished Professor-in-Residence
InstituteSchool of Life Science and Technology
Department of Cell Biology, Yale University
Research Areacell biology
Contact Info.james.rothman@@yale.edu

Research Interests
Intracellular vesicles transport; mechanism of neurotransmitter secretion

Selected Publications
1.Complexin Activates and Clamps SNAREpins by a Common Mechanism Involving an Intermediate Energetic State. Li, F., Pincet, F., Perez, E., Giraudo, C.G., Tareste, D., Rothman, J.E. Nat. Struct. Mol. Biol. 2011; 18, 941-46.
2.2Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes. Lavieu, G., Orci, L., Shi, L., Geiling, M., Ravazzola, M., Wieland, F., Cosson, P., Rothman, J. E. Proc. Natl. Acad. Sci. 2010; 107, 6876-81.
3.Alternative zippering as an on-off switch for SNARE-mediated fusion. Giraudo, C.G., Garcia-Diaz, A., Eng, W.S., Chen, Y., Hendrickson, W.A., Melia, T.J., Rothman, J.E. Science (New York, N.Y.) 2009; 323(5913): 512-6.
4.Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins. Shen, J., Tareste, D.C., Paumet, F., Rothman, J.E., Melia T.J. Cell 2007; 128(1): 183-95.