Yifeng Zhang    Assistant Professor, PI
InstituteSchool of Life Science and Technology
Research AreaSports Medicine
Contact Info.zhangyf3@@shanghaitech.edu.cn

Dr. Yifeng ZHANG graduated from The First Clinical Medical College of Shan Xi Medical University in Tai Yuan in 2006, and received his bachelor degree of Clinical Medicine. He received his master degree of Biomedical Engineering from College of Engineering in Peking University in 2007 and doctor degree of Orthopedics and Traumatology from The Chinese University of Hong Kong in 2015. Then he worked as an Assistant Researcher in Jun 2015 in Nanjing University till 2019. From Feb 2019, he become an Assistant Professor in School of Life Science and Technology, ShanghaiTech University.

Research Interests
Dr Zhang’s research group is focused on basic research of Muscular-skeletal diseases, and developing novel biomaterials to promote fracture healing, osteoarthritis treatment, and tendon-bone joint interface repairing. To solve the main illnesses in Sports Medicine such as : Osteoporosis, Osteonecrosis, Tendon-bone destruction, Non-healing bone fracture, Neuromuscular diseases, we aim to explore the mechanism of these musculoskeletal diseases, and develop the biomaterials, medical apparatus and therapeutic drugs for patients.
Dr ZHANG and his collaborators firstly illustrate the mechanism of magnesium metal’s intramembrane ossification effect in vivo, and designed a novel magnesium ion releasing intramedullary needle for promoting osteoporotic fracture healing. Then after, Dr ZHANG’s group developed 3 kinds of multi-layers coating on magnesium metal surface to control magnesium degradation in vivo. That makes the direct usage of metal magnesium in fracture fixation to be possible. Meanwhile, the group focused on the cell transdifferentiation in endochondro-ossification process. Controlling fracture healing by affecting cell plasticity are studied in NAMPT and Mg ions project. Based on Mg ions’ inhibiting effect on stem cell senescence, and its effect on keeping stem cell pluri-potency, our group are designing Mg ion control-releasing nanoparticles to treat osteoarthritis, and magnesium interface screws to fix and heal tendon-bone interface damage.
1.The mechanism of acquiring cell plasticity and asymmetric division of chondrocytes in transdifferentiating to osteoblasts.
2.The healing mechanism of repairing tendon-bone tearing by maintaining stem cell pluripotency in tendon-bone interface.
3.Designing and developing of biodegradable magnesium implants /or cell sheet to fixing and repairing cruciate ligaments and rotator cuff damage.
4.Designing and developing of biodegradable magnesium implants to fixing bone fracture.
5.Novel drug control-releasing materials in osteoarthritis treatment (Mg ions/ Cerium Oxide/ FK866 control-releasing PLGA nanoparticles).

Selected Publications
1. Zhang YF#, Xu J#, Ruan YC#, Yu MK, O'Laughlin M, Wise H, et al. Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats. Nature Medicine. 2016;22:1160-9.
2. Zhang YF, Zheng YF, Qin L. A comprehensive biological evaluation of ceramic nanoparticles as wear debris. Nanomed-Nanotechnol. 2011;7:975-82.
3. Zhang YF, Xu J, Qin L, Qing J. Magnesium and osteoarthritis: from a new perspective. Annual Of Joints. 2016;6:563-8.
4. Zhang YF, Zheng YF, Qin L. The potential biohazards of nanosized wear particles at bone-prosthesis interface. Asia-Pac J Chem Eng. 2011;6:563-8.
5. Huang S, Xu L, Sun Y, Zhang YF, Li G. The fate of systemically administrated allogeneic mesenchymal stem cells in mouse femoral fracture healing. Stem Cell Res Ther. 2015;6:206.  
6. Systemic and Local Administration of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells Promotes Fracture Healing in Rats. Huang, Shuo; Xu, Liangliang; Zhang, Yifeng; Sun, Yuxin; Li, Gang, CELL TRANSPLANTATION, 2015, 24(12): 2643~2655. 
7. Bingyang Dai, Qiangqiang Li, Xiaoxiao Song, Yuxiang Ge, Jing Wu, Kaijia Zhang, Chao Wang, Yifeng Zhang, Huajian Teng, Chaojun Li, Qing Jiang. Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice. J Bone Miner Metab. 2017. DOI 10.1007/s00774-017-0824-9.