2024年科研成果

5月

24. The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson's disease.

Shuanglong Yi, Linfang Wang,Margaret S Ho, Shiping Zhang.

Neural Regen Res. 2024 May;19(5):1150-1155. doi: 10.4103/1673-5374.382259.

3月

23. Flexible scaffold-based cheminformatics approach for polypharmacological drug design.

Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H Eric Xu, Jianjun Cheng, Sheng Wang.

Cell. 2024 Mar 21:S0092-8674(24)00237-X. doi: 10.1016/j.cell.2024.02.034. Online ahead of print.

22. Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis.

Shan Gao #, Fangyu Wu #, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang.

Nat Microbiol. 2024 Mar 15. doi: 10.1038/s41564-024-01643-8. Online ahead of print.

21. Interplay Between Intracellular Transport Dynamics and Liquid-Liquid Phase Separation.

Ming-Li Zhang, Ziheng Zhang, Xue-Zhi Niu, Hui-Ying Ti, Yu-Xuan Zhou, Bo Gao, Yiwei Li, Ji-Long Liu, Xiaosong Chen, Hui Li.

Adv Sci (Weinh). 2024 Mar 6:e2308338. doi: 10.1002/advs.202308338. Online ahead of print.

20. Targeting the intracellular neurexin interactome by in vivo proximity ligation.

Ming-Han Wang, Yue Hao, Xia-Jing Tong.

Trends Neurosci. 2024 Mar 6:S0166-2236(24)00023-7. doi: 10.1016/j.tins.2024.02.007. Online ahead of print.

19. Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging.

Hankui Cheng, Du Chen, Xiao Li, Umar Al-Sheikh, Duo Duan, Yuedan Fan, Linhui Zhu, Wanxin Zeng, Zhitao Hu, Xiajing Tong, Guohua Zhao, Yongming Zhang, Wenjuan Zou, Shumin Duan, Lijun Kang.

Neuron. 2024 Mar 1:S0896-6273(24)00090-4. doi: 10.1016/j.neuron.2024.02.006. Online ahead of print.

2月

18. CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization.

Shizhen Qiu#,Jian Chen#,Tao Wu#, Li Li Gang Wang,Haitao Wu, Xianmin Song,Xuesong Liu, Haopeng Wang.

Cell Res. 2024 Feb 14. doi: 10.1038/s41422-024-00936-1. Online ahead of print.

17. A case of too much sugar: Lung DCs flummoxed by flu.

Ying Xi, Tiffany Horng.

Immunity. 2024 Feb 13;57(2):203-205. doi: 10.1016/j.immuni.2024.01.014.

16. Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8.

Shan Jiang, Xi Lin, Lijie Wu, Ling Wang, Yiran Wu, Ziyi Xu, Fei Xu.

Sci Adv. 2024 Feb 2;10(5):eadj7500. doi: 10.1126/sciadv.adj7500. Epub 2024 Feb 2.

15. Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis.

Yadong Fu, Xiaoxi Zhou, Lin Wang, Weiguo Fan, Siqi Gao, Danyan Zhang, Zhiyang Ling, Yaguang Zhang, Liyan Ma, Fang Bai, Jiamei Chen, Bing Sun, Ping Liu.

Redox Biol. 2024 Feb:69:103029. doi: 10.1016/j.redox.2024.103029. Epub 2024 Jan 3.

14. Acquisition and Analysis of DIA-Based Proteomic Data: A Comprehensive Survey in 2023.

Ronghui Lou, Wenqing Shui.

Mol Cell Proteomics. 2024 Feb;23(2):100712. doi: 10.1016/j.mcpro.2024.100712. Epub 2024 Jan 3.

1月

13. Epigenetic regulation in adult neural stem cells.

Jiajia Shi, Zilin Wang, Zhijun Wang, Guofeng Shao,Xiajun Li.

Front Cell Dev Biol. 2024 Jan 31:12:1331074. doi: 10.3389/fcell.2024.1331074. eCollection 2024.

12. BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases.

Hongyuan Zhang, Jiacheng Ma, Zhaowei Wu, Xiaoyang Chen, Yangyang Qian, Weizhong Chen, Zhipeng Wang, Ya Zhang, Huanhu Zhu, Xingxu Huang, Quanjiang Ji.

Nat Commun. 2024 Jan 27;15(1):825. doi: 10.1038/s41467-024-45114-4.

11. Connecting Hippo Pathway and Cytoophidia in Drosophila Posterior Follicle Cells.

Rui-Yu Weng, Lei Zhang, Ji-Long Liu.

Int J Mol Sci. 2024 Jan 25;25(3):1453. doi: 10.3390/ijms25031453.

10. Association between glycemia risk index and arterial stiffness in type 2 diabetes.

Lingli Cai, Wenqi Shen, Jiang Li, Bin Wang, Ying Sun, Yi Chen, Ling Gao,Fei Xu, Xinhua Xiao, Ningjian Wang, Yingli Lu.

J Diabetes Investig. 2024 Jan 22. doi: 10.1111/jdi.14153. Online ahead of print.

9. An Electroencephalography Profile of Paroxysmal Kinesigenic Dyskinesia.

Huichun Luo, Xiaojun Huang, Ziyi Li, Wotu Tian, Kan Fang, Taotao Liu, Shige Wang, Beisha Tang, Ji Hu, Ti-Fei Yuan, Li Cao.

Adv Sci (Weinh). 2024 Jan 16:e2306321. doi: 10.1002/advs.202306321. Online ahead of print.

8. BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma.

Dongdong Liu, Zhen Li, Dongxia Tan, Yang An, Liping Chu, Tiancheng Chen, Weijia Li, Ailin Zhou, Ruijie Xiang,Liye Zhang,Yuxiu Qu,Wei Qi.

Adv Sci (Weinh). 2024 Jan 16:e2306499. doi: 10.1002/advs.202306499. Online ahead of print.

7. Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants.

Wenwen Duan, Dongmei Cao, Sheng Wang,Jianjun Cheng.

Chem Rev. 2024 Jan 10;124(1):124-163. doi: 10.1021/acs.chemrev.3c00375. Epub 2023 Nov 30. 

6. A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.

Zhibin Zhang #, Xi Lin #, Ling Wei #, Yiran Wu, Lu Xu, Lijie Wu, Xiaohu Wei, Suwen Zhao, Xiangjia Zhu, Fei Xu.

Cell Discov. 2024 Jan 5;10(1):3. doi: 10.1038/s41421-023-00627-y. 

5. Roles and regulation of tRNA-derived small RNAs in animals.

Sowndarya Muthukumar #, Cai-Tao Li #, Ru-Juan Liu, Cristian Bellodi.

Nat Rev Mol Cell Biol. 2024 Jan 5. doi: 10.1038/s41580-023-00690-z. Online ahead of print. 

4. THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development.

Jiali Zhang #, Zhenzhou Jiang #, Xueyuan Zhang, Ziqun Yang, Jinjiao Wang, Jialing Chen, Li Chen, Minfang Song, Yanchun Zhang, Mei Huang, Shengmiao Chen, Xuexue Xiong, Yuetong Wang, Piliang Hao,Tiffany Horng,Min Zhuang,Liye Zhang,Erwei Zuo,Fang Bai,Jie Zheng, Haopeng Wang,Gaofeng Fan.

Nat Struct Mol Biol. 2024 Jan 4. doi: 10.1038/s41594-023-01131-3. Online ahead of print.

3. Cytoophidia Influence Cell Cycle and Size in Schizosaccharomyces pombe.

Ruolan Deng, Yi-Lan Li,Ji-Long Liu.

Int J Mol Sci. 2024 Jan 3;25(1):608. doi: 10.3390/ijms25010608.

2. Critical role of TPRN rings in the stereocilia for hearing.

Jieyu Qi, Fangzhi Tan, Liyan Zhang, Yinyi Zhou, Ziyu Zhang, Qiuhan Sun, Nianci Li, Yuan Fang, Xin Chen, Yunhao Wu, Guisheng Zhong, Renjie Chai.

Mol Ther. 2024 Jan 3;32(1):204-217. doi: 10.1016/j.ymthe.2023.11.011. Epub 2023 Nov 11.

1. THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration.

Wen-Qing Yang,Jian-Yang Ge,Xiaofeng Zhang,Wen-Yu Zhu,Lin Lin,Yigong Shi,Beisi Xu,Ru-Juan Liu.

Nucleic Acids Res. 2024 Jan 2:gkad1243. doi: 10.1093/nar/gkad1243. Online ahead of print.