• Researchers identify novel host factors of rhinovirus
    Recently, Assistant Professor Liu Jia’s group at SIAIS along with his collaborator, Professor Qu Jieming at Ruijin Hospital and the Institutes of Respiratory Diseases of Shanghai Jiao Tong University designed a novel surfaceome CRISPR library and identified OLFML3 as a novel host factor of rhinovirus (RV). They found that OLFML3 could promote RV infection by antagonizing type I interferon (IFN) s...
    2021-12-29
  • SIAIS researchers and collaborators unveil structure and conformation change of the entire Mediator complex
    On February 11, 2021, a research article entitled "Mediator structure and conformation change" was published in Molecular Cell. This report, based on a joint effort of the Lab of Structure Biochemistry at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and collaborators from Stanford describes, for the first time, the cryo-EM structure of the entire Mediator at a near...
    2021-02-11
  • SIAIS holds the fourth Meeting of the 1st SIAIS Academic Committee
    On December 18th, SIAIS held the fourth Meeting of the 1st SIAIS Academic Committee in the ShanghaiTech Conference Center. Thirteen SIAIS Academic Committee members, composed of distinguished experts in the field of biomedical research, and thirty representatives of SIAIS faculty attended the meeting.  The meeting was hosted by Rao Zihe, Distinguished Adjunct Professor of SIAIS and Membe...
    2020-12-31
  • The SIAIS research team reveals a piRNA-independent mechanism of  PIWI protein in gastric cancer
    On August 26th, 2020, a team led by SIAIS Distinguished Adjunct Professor Lin Haifan published new findings in PNAS in an article entitled “PIWIL1 Promotes Gastric Cancer via a piRNA-Independent Mechanism”. These findings reveal a new function and action mechanism of PIWI proteins in oncogenesis, guiding the identification of PIWI inhibitors to cure cancer.   Precision m...
    2020-12-29
  • The SIAIS Research Team Reveals the Heterogeneous Tumor Cells and Their Immune Microenvironment in Early-Stage Lung Adenocarcinomas
    On November 3rd, 2020, a team led by SIAIS Distinguished Adjunct Professor Fan Guoping and Research Associate Professor Zhu Xianmin published new findings in the Springer Nature Group Journal Oncogene with the title of “Single-cell RNA sequencing reveals the heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations”. This work is ...
    2020-11-18
  • SIAIS Researchers Unveil Structural Basis of Trehalose Recycling by the ABC Transporter LpqY-SugABC
    On October 30, 2020, a research article entitled “Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC” was published in Science Advances by a joint research team led by Prof. Rao Zihe, a Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS). This work reported four high-resolution cryo-electron microscopy structure...
    2020-11-11
  • Portrait Unveiling Ceremony for Professor Richard A. Lerner
    On the afternoon of November 2nd, the Portrait Unveiling Ceremony for Richard A. Lerner, Distinguished Adjunct Professor and the Founding Director of SIAIS, was held in the Y Building. Some distinguished guests together unveiled the portrait. Vice Director of SIAIS, Yang Haitao hosted the ceremony, and other attendees included Raymond Stevens, the Founding Director of iHuman Institute, Liu Zhijie,...
    2020-11-03
  • Noradrenergic Regulation of Pain by a Novel Type of the Spinal Cord Astrocytes
    Professor Katsuhiko Mikoshiba from the School of Life Science and Technology (SLST) and SIAIS, in collaboration with Professor Makoto Tsuda’s group in Kyushu University, have published research findings in Nature Neuroscience describing a novel type of astrocyte involved in pain regulation: Noradrenergic stimulation aggravates pain through the novel astrocytes, opposite to the classical...
    2020-10-28
  • Joint Team Led by SIAIS Professors Richard Lerner and Yang Guang Develops a Full Agonist Antibody Targeting Leptin Receptor
    Since developed in 1980s by Prof. Richard Lerner and Prof. Gregory Winter, 2018 Nobel Laureate in Chemistry, combinatorial antibody library technology has been applied in biomedical development and basic science research, etc. Prof. Richard Lerner extended the application of combinatorial antibody to many fields, such as enzyme catalysis, receptor activation and cell fate regulators...
    2020-10-15
  • 3D-STED Super-Resolution Microscopy Unravels the Mystery of Astrocytes at the Tripartite Synaptic Function
     Professor Katsuhiko Mikoshiba from SIAIS, with the French Professor Valentin Nägerl’s group unraveled the morphological mystery of astrocytes.  Misa Arizono, a former PhD student in Mikoshiba’s lab is the first author of this report in Nature Communications 2020.Astrocytes, which are the most numerous...
    2020-09-16
  • SIAIS and University of Queensland Researchers Unveil the Complete Structures of Plant and Fungal Acetohydroxyacid Synthase: The First Enzyme in the Branched-Chain Amino Acid Biosynthesis Pathway
    At 11 PM (Beijing Time) on 8th July, a new research finding was reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Luke Guddat (Visiting Professor at SIAIS and Professor at University of Queensland). The related research article entitled “Structures of fungal...
    2020-07-09
  • A Novel Chemistry to Incorporate Selenium into DNA-Encoded Libraries
    Recently, Angewandte Chemie International Edition published a collaborative study led by Professors Richard A. Lerner and Yang Guang from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University, entitled “A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries”. This paper has been highlighted as Very Important Paper (Top 5%...
    2020-06-02
  • Inhibitory Antibodies Identify Novel Sites of Therapeutic Vulnerability in Rhinovirus and Other Enteroviruses
    The 3C protease has long been the focus of enterovirus antiviral development. Nevertheless, although anti-enterovirus drugs have a potentially enormous global market, the nucleophilic active site of 3C has frustrated previous drug discovery efforts. Recently, a team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from the Laboratory of Antibody Structure at the Shanghai Institute for ...
    2020-06-01
  • Anti-TB Structure Center Opens at ShanghaiTech
    On May 8, 2020, the Founding Ceremony was held for the Anti-Tuberculosis (TB) Structure Center (A-TB Center) of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University. The ceremony was followed by the First Academic Symposium of the A-TB Center at SIAIS. President Jiang Mianheng and Professor Rao Zihe at SIAIS, Member of the Chinese Academy of Sciences (CAS), joi...
    2020-05-15