Lab of structural biology
Principal investigator
Name:
Junxia LuAssistant Professor , PhD, Assistant Professor
Position:
Affiliation:
School of Life Science and Technology
Honor:
Education Background:
- 1995/09-1999/07, Fudan University, B.S.
- 1999/09-2002/07, Fudan University, M.S.
- 2002/09-2007/07, Miami University, Ph.D.
Working Experience:
- 2007/08-2011/07, National Institute of Health (NIH, USA), Visiting Fellow
- 2012/04-2013/04, Pacific Northwest National Laboratory, Research Associate
- 2013/07-2015/04, National Institute of Health (NIH, USA), Research Fellow
- 2015/04-Present, ShanghaiTech University, School of Life Science and Technology, Assistant Professor (TENURE-TRACK)
Group Introduction
Research Area:
Structural Biology
Research Interests:
Dr. Lu’s research interest is focused on the structural study of protein assemblies involved in human diseases, such as Alzheimer’s disease and AIDS. The protein assemblies, such as amyloid-β fibrils formed in the brain plague of Alzheimer’s disease patients, are not soluble and in non-crystalline form, present a unique challenge for us to study. Solid-state NMR, as an idea technique to study these kinds of proteins, is applied in her research to understand the structural implication of these protein macrostructures to human disease.
Representative Publications (*First Author, # Corresponding Author)
- 1. Zhuo, Xiao-Feng*; Wang, Jian; Zhang, Jing; Jiang, Lei-Lei; Hu, Hong-Yu#; Lu, Jun-Xia#.Solid-State NMR Reveals the Structural Transformation of the TDP-43 Amyloidogenic Region upon Fibrillation.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 19 Feb 2020. 142(7):3412-3421.
- 2. Yi, Chunyan*; Xia, Jing; He, Lan; Ling, Zhiyang; Wang, Xuesong; Yan, Yu; Wang, Jiangjun; Zhao, Xinhao; Fan, Weiguo; Sun, Xiaoyu; Zhang, Ronghua; Ye, Sheng; Zhang, Rongguang; Xu, Yongfen; Ma, Liyan; Zhang, Yaguang; Zhou, Honglin; Huang, Zhong; Niu, Junqi; Long, Gang#; Lu, Junxia#; Zhong, Jin#; Sun, Bing#.Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.CELLULAR & MOLECULAR IMMUNOLOGY. 31 Mar 2020.
- 3. Song, Ruiheng*; Wu, Xialian; Xue, Bin; Yang, Yuqin; Huang, Wenmao; Zeng, Guixiang; Wang, Jian; Li, Wenfei; Cao, Yi; Wang, Wei#; Lu, Junxia#; Dong, Hao#.Principles Governing Catalytic Activity of Self-Assembled Short Peptides.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 09 Jan 2019. 141(1):223-231.
- 4. Ma, Cheng-Wei*; Zhang, Jing; Dong, Xing-Qi; Lu, Jun-Xia#.Amyloid structure of high-order assembly of Leucine-rich amelogenin revealed by solid-state NMR.JOURNAL OF STRUCTURAL BIOLOGY. Apr 2019. 206(1):29-35.
- 5. Arachchige, Rajith Jayasinha*; Burton, Sarah D.; Lu, Jun-Xia; Ginovska, Bojana; Harding, Larisa K.; Tao, Jinhui; Dohnalkova, Alice; Tarasevich, Barbara J.; Buchko, Garry W.#; Shaw, Wendy J.#.Solid-State NMR Identification of Intermolecular Interactions in Amelogenin Bound to Hydroxyapatite.BIOPHYSICAL JOURNAL. 06 Nov 2018. 115(9):1666-1672.
- 6. He, Lan*; Gu, Wangpeng; Wang, Meng; Chang, Xiaoyan; Sun, Xiaoyu; Zhang, Yuan; Lin, Xuan; Yan, Chenghua; Fan, Weiguo; Su, Pan; Wang, Yanming; Yi, Chunyan; Lin, Guomei; Li, Li; Jiang, Yu; Lu, Junxia; Dong, Chen; Wang, Haikun#; Sun, Bing#.Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 21 Aug 2018. 115(34):8621-8626.
- 7. Qiang, Wei*; Yau, Wai-Ming; Lu, Jun-Xia; Collinge, John#; Tycko, Robert#.Structural variation in amyloid-beta fibrils from Alzheimer's disease clinical subtypes.NATURE. 12 Jan 2017. 541(7636):217-+.
- 8. Lu, Jun-Xia#*; Dong, Xing-Qi; Zhang, Jian-Jun.Solid-State Structure of Abeta (A beta) in Alzheimer's Disease.PROTEIN AND PEPTIDE LETTERS. 2017. 24(4):322-330.
- 9. Lu, Jun-Xia*; Bayro, Marvin J.; Tycko, Robert#.Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments.JOURNAL OF BIOLOGICAL CHEMISTRY. 17 Jun 2016. 291(25):13098-13112.
- 10. Lu, Jun-xia*; Burton, Sarah D.; Xu, Yimin S.; Buchko, Garry W.; Shaw, Wendy J.#.The flexible structure of the K24S28 region of Leucine-Rich Amelogenin Protein (LRAP) bound to apatites as a function of surface type, calcium, mutation, and ionic strength.FRONTIERS IN PHYSIOLOGY. 2014. 5.
- 11. Lu, Jun-Xia*; Qiang, Wei; Yau, Wai-Ming; Schwieters, Charles D.; Meredith, Stephen C.; Tycko, Robert#.Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue.CELL. 2013. 154(6):1257-1268.
- 12. Lu, J. X.*; Xu, Y. S.; Buchko, G. W.; Shaw, W. J.#.Mineral Association Changes the Secondary Structure and Dynamics of Murine Amelogenin.JOURNAL OF DENTAL RESEARCH. 2013. 92(11):1000-1004.
- 13. Lu, Jun-xia*; Xu, Yimin Sharon; Shaw, Wendy J.#.Phosphorylation and Ionic Strength Alter the LRAP-HAP Interface in the N-Terminus.BIOCHEMISTRY. 2013. 52(13):2196-2205.
- 14. Lu, Jun-Xia*; Sharpe, Simon; Ghirlando, Rodolfo; Yau, Wai-Ming; Tycko, Robert#.Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers.PROTEIN SCIENCE. 2010. 19(10):1877-1896.
- 15. Lu, Jun-Xia*; Yau, Wai-Ming; Tycko, Robert#.Evidence from Solid-State NMR for Nonhelical Conformations in the Transmembrane Domain of the Amyloid Precursor Protein.BIOPHYSICAL JOURNAL. 2011. 100(3):711-719.
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