Principal investigator
Name:
Shuhua XuDistinguished Adjunct Professor from CAS , PhD, Distinguished Adjunct Professor from CAS
Position:
Affiliation:
School of Life Science and Technology, Institute of Computational Biology, Shanghai Institutes for Biological Sciences, CAS
Honor:
Group Introduction
Research Area:
Population Genomics
Research Interests:
Human Population Genomics and Microevolution Modeling linkage disequilibrium and recombination Inference of human population admixture and migration history Detection of footprints of natural selection in the human genome (focusing on Asian populations, but including as well investigation of human microbiomes) Exploring the medical and evolutionary impact of genetic admixture
Representative Publications (*First Author, # Corresponding Author)
- 1. Deng, Lian*; Hoh, Boon-Peng; Lu, Dongsheng; Saw, Woei-Yuh; Ong, Rick Twee-Hee; Kasturiratne, Anuradhani; de Silva, H. Janaka; Zilfalil, Bin Alwi; Kato, Norihiro; Wickremasinghe, Ananda R.; Teo, Yik-Ying; Xu, Shuhua#.Dissecting the genetic structure and admixture of four geographical Malay populations.SCIENTIFIC REPORTS. 23 Sep 2015. 5.
- 2. Wang, Yuchen*; Lu, Dongsheng; Chung, Yeun-Jun; Xu, Shuhua#.Genetic structure, divergence and admixture of Han Chinese, Japanese and Korean populations.HEREDITAS. 06 Apr 2018. 155.
- 3. Yew, Chee Wei*; Hoque, Mohd Zahirul; Pugh-Kitingan, Jacqueline; Minsong, Alexander; Voo, Christopher Lok Yung; Ransangan, Julian; Lau, Sophia Tiek Ying; Wang, Xu; Saw, Woei Yuh; Ong, Rick Twee-Hee; Teo, Yik-Ying; Xu, Shuhua; Hoh, Boon-Peng; Phipps, Maude E.; Kumar, S. Vijay#.Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data.ANNALS OF HUMAN GENETICS. Jul 2018. 82(4):216-226.
- 4. Yew, Chee-Wei*; Lu, Dongsheng; Deng, Lian; Wong, Lai-Ping; Ong, Rick Twee-Hee; Lu, Yan; Wang, Xiaoji; Yunus, Yushimah; Aghakhanian, Farhang; Mokhtar, Siti Shuhada; Hoque, Mohammad Zahirul; Voo, Christopher Lok-Yung; Rahman, Thuhairah Abdul; Bhak, Jong; Phipps, Maude E.; Xu, Shuhua; Teo, Yik-Ying; Kumar, Subbiah Vijay#; Hoh, Boon-Peng#.Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia.HUMAN GENETICS. Feb 2018. 137(2):161-173.
- 5. Ni, Xumin*; Yang, Xiong; Guo, Wei; Yuan, Kai; Zhou, Ying; Ma, Zhiming#; Xu, Shuhua#.Length Distribution of Ancestral Tracks under a General Admixture Model and Its Applications in Population History Inference.SCIENTIFIC REPORTS. 28 Jan 2016. 6.
- 6. Ni, Xumin*; Yuan, Kai; Yang, Xiong; Feng, Qidi; Guo, Wei; Ma, Zhiming#; Xu, Shuhua#.Inference of multiple-wave admixtures by length distribution of ancestral tracks.HEREDITY. Jul 2018. 121(1):52-63.
- 7. Fu, Ruiqing*; Mokhtar, Siti Shuhada; Phipps, Maude Elvira; Hoh, Boon-Peng; Xu, Shuhua#.A genome-wide characterization of copy number variations in native populations of Peninsular Malaysia.EUROPEAN JOURNAL OF HUMAN GENETICS. Jun 2018. 26(6):886-897.
- 8. Deng, Lian*; Xu, Shuhua#.Adaptation of human skin color in various populations.HEREDITAS. 15 Jun 2017. 155.
- 9. Zhang, Cheng*; Lu, Jianqi; Lou, Haiyi; Du, Renqian; Xu, Shuhua; Shen, Yiping; Zhang, Feng#; Jin, Li#.CNVbase: Batch identification of novel and rare copy number variations based on multi-ethnic population data.JOURNAL OF GENETICS AND GENOMICS. 20 Jul 2017. 44(7):367-370.
- 10. Liu, Xuanyao*; Lu, Dongsheng; Saw, Woei-Yuh; Shaw, Philip J.; Wangkumhang, Pongsakorn; Ngamphiw, Chumpol; Fucharoen, Suthat; Lert-itthiporn, Worachart; Chin-inmanu, Kwanrutai; Tran Nguyen Bich Chau; Anders, Katie; Kasturiratne, Anuradhani; de Silva, H. Janaka; Katsuya, Tomohiro; Kimura, Ryosuke; Nabika, Toru; Ohkubo, Takayoshi; Tabara, Yasuharu; Takeuchi, Fumihiko; Yamamoto, Ken; Yokota, Mitsuhiro; Mamatyusupu, Dolikun; Yang, Wenjun; Chung, Yeun-Jun; Jin, Li; Hoh, Boon-Peng; Wickremasinghe, Ananda R.; Ong, RickTwee-Hee; Khor, Chiea-Chuen; Dunstan, Sarah J.; Simmons, Cameron; Tongsima, Sissades; Suriyaphol, Prapat; Kato, Norihiro; Xu, Shuhua; Teo, Yik-Ying#.Characterising private and shared signatures of positive selection in 37 Asian populations.EUROPEAN JOURNAL OF HUMAN GENETICS. Apr 2017. 25(4):499-508.
- 11. Qin, Pengfei*; Zhou, Ying; Lou, Haiyi; Lu, Dongsheng; Yang, Xiong; Wang, Yuchen; Jin, Li; Chung, Yeun-Jun; Xu, Shuhua#.Quantitating and Dating Recent Gene Flow between European and East Asian Populations.SCIENTIFIC REPORTS. 02 Apr 2015. 5.
- 12. Deng, Lian*; Ruiz-Linares, Andres; Xu, Shuhua#; Wang, Sijia#.Ancestry variation and footprints of natural selection along the genome in Latin American populations.SCIENTIFIC REPORTS. 18 Feb 2016. 6.
- 13. Wu, Sijie*; Tan, Jingze; Yang, Yajun; Peng, Qianqian; Zhang, Manfei; Li, Jinxi; Lu, Dongsheng; Liu, Yu; Lou, Haiyi; Feng, Qidi; Lu, Yan; Guan, Yaqun; Zhang, Zhaoxia; Jiao, Yi; Sabeti, Pardis; Krutmann, Jean; Tang, Kun; Jin, Li#; Xu, Shuhua#; Wang, Sijia#.Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.HUMAN GENETICS. Nov 2016. 135(11):1279-1286.
- 14. Jha, Pankaj*; Lu, Dongsheng; Xu, Shuhua#.Natural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing Data.PLOS ONE. 08 Jun 2015. 10(6).
- 15. Takeuchi, Fumihiko#*; Katsuya, Tomohiro; Kimura, Ryosuke; Nabika, Toru; Isomura, Minoru; Ohkubo, Takayoshi; Tabara, Yasuharu; Yamamoto, Ken; Yokota, Mitsuhiro; Liu, Xuanyao; Saw, Woei-Yuh; Mamatyusupu, Dolikun; Yang, Wenjun; Xu, Shuhua; Teo, Yik-Ying; Kato, Norihiro#.The fine-scale genetic structure and evolution of the Japanese population.PLOS ONE. Nov 2017. 12(11).
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