课题组长
姓名：
吴家睿中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
生命科学与技术学院执行院长（2012年12月-2019年2月）
所在院所：
生命科学与技术学院、中国科学院分子细胞科学卓越创新中心
荣誉称号：
课题组简介
研究方向：
以系统生物学方法研究II型糖尿病发病机制
研究内容：
细胞的各种活动，如细胞增殖、分化和凋亡等不是互不相关的孤立过程，而是紧密联系、高度协调的互动过程。因此，细胞内一定存在一个调控这些活动的分子网络。目前其课题组正从事涉及到细胞周期调控和凋亡互动的研究，以及细胞周期和细胞分化之间关系的研究。此外，其课题组倡导用系统生物学的研究策略来研究生物复杂系统和复杂性疾病，目前正在用系统生物学的研究策略进行2型糖尿病发病机制方面的研究。
代表性论文（*第一作者，#通讯作者）
- 1. Song, Wei*; Wang, Jiguang; Yang, Ying; Jing, Naihe; Zhang, Xiangsun; Chen, Luonan#; Wu, Jiarui#.Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis.JOURNAL OF MOLECULAR CELL BIOLOGY. 2012. 4(4):197-26.
- 2. Su, Zhi-Duan*; Sun, Liang; Yu, Dan-Xia; Li, Rong-Xia; Li, Huai-Xing; Yu, Zhi-Jie; Sheng, Quan-Hu; Lin, Xu; Zeng, Rong#; Wu, Jia-Rui#.Quantitative detection of single amino acid polymorphisms by targeted proteomics.JOURNAL OF MOLECULAR CELL BIOLOGY. 2011. 3(5):39-315.
- 3. Guo, Wei*; Zhang, Kun-Ming; Tu, Kang; Li, Yi-Xue; Zhu, Li; Xiao, Hua-Sheng; Yang, Ying; Wu, Jia-Rui#.Adipogenesis licensing and execution are disparately linked to cell proliferation.CELL RESEARCH. 2009. 19(2):216-223.
- 4. Xiong, Lei*; Kou, Fei; Yang, Ying; Wu, Jiarui#.A novel role for 1GF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop.JOURNAL OF CELL BIOLOGY. 2007. 178(6):995-17.
- 5. Wang, Zhenguo*; Wang, Lu; Zhang, Zhuzhen; Feng, Li; Song, Xue; Wu, Jiarui#.Apolipoprotein A-IV involves in glucose and lipid metabolism of rat.NUTRITION & METABOLISM. 02 Jul 2019. 16.
- 6. Liu, Xiaojing*; Han, Shuai; Yang, Ying; Kang, Jiuhong; Wu, Jiarui#.Glucose-induced glutathione reduction in mitochondria is involved in the first phase of pancreatic beta-cell insulin secretion.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 28 Aug 2015. 464(3):730-736.
- 7. Zi, Zhenzhen#*; Zhang, Zhuzhen; Li, Qingrun; An, Weiwei; Zeng, Liyong; Gao, Dayuan; Yang, Ying; Zhu, Xueliang; Zeng, Rong; Shum, Winnie Waichi; Wu, Jiarui.CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.PLOS GENETICS. Aug 2015. 11(8).
- 8. An, Weiwei*; Zhang, Zhuzhen; Zeng, Liyong; Yang, Ying; Zhu, Xueliang; Wu, Jiarui#.Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.PLOS ONE. 10 Jul 2015. 10(7).
- 9. Li, Qing-Run*; Wang, Zi-Ming; Albrechtsen, Nicolai J. Wewer; Wang, Dan-Dan; Su, Zhi-Duan; Gao, Xian-Fu; Wu, Qing-Qing; Zhang, Hui-Ping; Zhu, Li; Li, Rong-Xia; Jacobsen, SivHesse; Jorgensen, Nils Bruun; Dirksen, Carsten; Bojsen-Moller, Kirstine N.; Petersen, Jacob S.; Madsbad, Sten; Clausen, Trine R.; Diderichsen, Borge; Chen, Luo-Nan#; Holst, Jens J.#; Zeng, Rong#; Wu, Jia-Rui#.Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery.EBIOMEDICINE. Feb 2018. 28:234-240.
- 10. Guo, Wei*; Chen, Jiangnan; Yang, Ying; Zhu, Jianbei; Wu, Jiarui#.Epigenetic programming of Dnmt3a mediated by AP2 alpha is required for granting preadipocyte the ability to differentiate.CELL DEATH & DISEASE. Dec 2016. 7.
- 11. Liu, Xiaojing*; Wang, Zhenguo; Yang, Ying; Li, Qingrun; Zeng, Rong; Kang, Jiuhong; Wu, Jiarui#.Rab1A mediates proinsulin to insulin conversion in beta-cells by maintaining Golgi stability through interactions with golgin-84.PROTEIN & CELL. Sep 2016. 7(9):692-696.
- 12. Tang, Jia-shu*; Li, Qing-run; Li, Jia-ming; Wu, Jia-rui#; Zeng, Rong#.Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics.SCIENTIFIC REPORTS. 21 Apr 2017. 7.
- 13. Li, Jiaming*; Li, Qingrun; Tang, Jiashu; Xia, Fangying; Wu, Jiarui#; Zeng, Rong.Quantitative Phosphoproteomics Revealed Glucose-Stimulated Responses of Islet Associated with Insulin Secretion.JOURNAL OF PROTEOME RESEARCH. Nov 2015. 14(11):4635-4646.
- 14. Sun, Liang*; Liang, Liming; Gao, Xianfu; Zhang, Huiping; Yao, Pang; Hu, Yao; Ma, Yiwei; Wang, Feijie; Jin, Qianlu; Li, Huaixing; Li, Rongxia; Liu, Yong; Hu, Frank B.; Zeng, Rong#; Lin, Xu#; Wu, Jiarui#.Early Prediction of Developing Type 2 Diabetes by Plasma Acylcarnitines: A Population-Based Study.DIABETES CARE. Sep 2016. 39(9):1563-1570.
- 15. Hu, Rongkuan*; Yan, Huan; Fei, Xiaoyan; Liu, Haiyang#; Wu, Jiarui#.Modulation of glucose metabolism by a natural compound from Chloranthus japonicus via activation of AMP-activated protein kinase.SCIENTIFIC REPORTS. 10 Apr 2017. 7.
- 16. Wu, Li*; Luo, Siwei; Ma, Siya; Liang, Zhi#; Wu, Jia-Rui#.Construction of light-sensing two-component systems in Escherichia coli.SCIENCE BULLETIN. 2017. 62(12):813-815.
- 17. Li, Meiyi*; Li, Chen; Liu, Wei-Xin; Liu, Conghui; Cui, Jingru; Li, Qingrun; Ni, Hong; Yang, Yingcheng; Wu, Chaochao; Chen, Chunlei; Zhen, Xing; Zeng, Tao; Zhao, Mujun; Chen, Lei; Wu, Jiarui#; Zeng, Rong#; Chen, Luonan#.Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma.JOURNAL OF MOLECULAR CELL BIOLOGY. Dec 2017. 9(6):489-503.
- 18. Luo, Si-Wei*; Liang, Zhi#; Wu, Jia-Rui#.Simultaneously measuring multiple protein interactions and their correlations in a cell by Protein-interactome Footprinting.SCIENTIFIC REPORTS. 24 Mar 2017. 7.
- 19. Luo, Siwei*; Jiang, Yihua; Liang, Zhi#; Wu, Jiarui.Quantitative detection of in vivo physical protein - protein interactions based on DNA sequence recognition.JOURNAL OF MOLECULAR CELL BIOLOGY. Aug 2015. 7(4):383-386.
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