课题组长
姓名：
谢欣中科院特聘教授 研究员 博士生导师, PhD, 中科院特聘教授
职务：
所在院所：
生命科学与技术学院、中国科学院上海药物研究所
荣誉称号：
课题组简介
研究内容：
从事基于G蛋白偶联受体（GPCR）的新药发现及干细胞化学生物学研究，主要集中在以下几个方向：1.GPCR新药筛选平台的建设及新药发现。 2.GPCR在重大疾病（自身免疫病、代谢性疾病及肿瘤）中的作用及其机制研究，以及药物干预。 3.干细胞命运调控小分子的发现、机制研究及在疾病中的应用。
代表性论文（*第一作者，#通讯作者）
- 1. Du, Changsheng*; Duan, Yanhui; Wei, Wei; Cai, Yingying; Chai, Hui; Lv, Jie; Du, Xiling; Zhu, Jian; Xie, Xin#.Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.NATURE COMMUNICATIONS. 2016. 7.
- 2. Long, Yuan*; Wang, Min; Gu, Haifeng; Xie, Xin#.Bromodeoxyuridine promotes full-chemical induction of mouse pluripotent stem cells.CELL RESEARCH. 2015. 25(10):1171-1174.
- 3. Fu, Yanbin*; Huang, Chenwen; Xu, Xinxiu; Gu, Haifeng; Ye, Youqiong; Jiang, Cizhong; Qiu, Zilong; Xie, Xin#.Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails.CELL RESEARCH. 2015. 25(9):113-124.
- 4. Kong, Xiangqian*; Liu, Jian; Li, Lianchun; Yue, Liyan; Zhang, Lihong; Jiang, Hualiang; Xie, Xin#; Luo, Cheng#.Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition.NUCLEIC ACIDS RESEARCH. 2015. 43(9):4381-4392.
- 5. Zhang, Shuyong*; Ma, Yuyong; Li, Jing; Ma, Junjun; Yu, Biao#; Xie, Xin#.Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014. 111(40):14571-14576.
- 6. Chen, Guofang*; Xu, Xinxiu; Zhang, Lihong; Fu, Yanbin; Wang, Min; Gu, Haifeng; Xie, Xin#.Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell self-renewal and somatic cell reprogramming.CELL RESEARCH. 2014. 24(9):1121-1136.
- 7. Xu, Xinxiu*; Wang, Quan; Long, Yuan; Zhang, Ru; Wei, Xiaoyuan; Xing, Mingzhe; Gu, Haifeng; Xie, Xin#.Stress-mediated p38 activation promotes somatic cell reprogramming.CELL RESEARCH. 2013. 23(1):131-141.
- 8. Wang, Quan*; Xu, Xinxiu; Li, Jun; Liu, Jing; Gu, Haifeng; Zhang, Ru; Chen, Jiekai; Kuang, Yin; Fei, Jian; Jiang, Cong; Wang, Ping; Pei, Duanqing; Ding, Sheng; Xie, Xin#.Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells.CELL RESEARCH. 2011. 21(10):1424-1435.
- 9. He, Xing*; Fang, Liyan; Wang, Jue; Yi, Yanghua; Zhang, Shuyu; Xie, Xin#.Bryostatin-5 Blocks Stromal Cell-Derived Factor-1 Induced Chemotaxis via Desensitization and Down-regulation of Cell Surface CXCR4 Receptors.CANCER RESEARCH. 2008. 68(21):8678-8686.
- 10. Lin, Xi*; Li, Mingyue*; Wang, Niandong*; Wu, Yiran*; Luo, Zhipu; Guo, Shimeng; Han, Gye-Won; Li, Shaobai; Yue, Yang; Wei, Xiaohu; Xie, Xin; Chen, Yong; Zhao, Suwen; Wu, Jian#; Lei, Ming#; Xu, Fei#.Structural basis of ligand recognition and self-activation of orphan GPR52.NATURE. 19 Feb 2020.
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